The development of vestibulo-ocular circuitry in the chicken embryo

This article reviews studies of the organization and development of the vestibulo-ocular reflex arc in the chicken embryo. It summarizes some of the principal features that characterize the development of this circuit, including the gradual clustering of motoneurons in the oculomotor nucleus into functionally identifiable motoneuron pools, the patterning of vestibular projection neurons into coherent clusters with specific axonal trajectories and terminations onto the oculomotor motoneuron pools, the reverse order of synapse formation during development (motoneuron to muscle, then vestibular projection neuron to motoneuron), and the selectivity of initial synaptic termination at both the ultimate and penultimate relays within the reflex arc. Reference to studies in other vertebrate species is made to provide a comparative context, and potential mechanisms are discussed that may contribute to the underlying synaptic specificity in this circuit.

[1]  Jan G Bjaalie,et al.  The relationship between hodological and cytoarchitectonic organization in the vestibular complex of the 11‐day chicken embryo , 2003, The Journal of comparative neurology.

[2]  Silvia Arber,et al.  ETS Gene Er81 Controls the Formation of Functional Connections between Group Ia Sensory Afferents and Motor Neurons , 2000, Cell.

[3]  B. Mendelson.  Chronic embryonic MK-801 exposure disrupts the somatotopic organization of cutaneous nerve projections in the chick spinal cord. , 1994, Brain research. Developmental brain research.

[4]  L. Puelles.  A Golgi-Study of oculomotor neuroblasts migrating across the midline in chick embryos , 1978, Anatomy and Embryology.

[5]  R. Baker,et al.  Rhombomeric organization of vestibular pathways in larval frogs , 2001, The Journal of comparative neurology.

[6]  L. Puelles,et al.  The relationship between rhombomeres and vestibular neuron populations as assessed in quail-chicken chimeras. , 1998, Developmental biology.

[7]  J. Glover.  The organization of vestibulo-ocular and vestibulospinal projections in the chicken embryo. , 1994, European journal of morphology.

[8]  R. Marcucio,et al.  Differentiation of avian craniofacial muscles: I. Patterns of early regulatory gene expression and myosin heavy chain synthesis , 1999, Developmental dynamics : an official publication of the American Association of Anatomists.

[9]  J. Glover.  Neuroepithelial 'compartments' and the specification of vestibular projections. , 2000, Progress in brain research.

[10]  P. Wenner,et al.  Environmental Specification of Neuronal Connectivity , 1993, Neuron.

[11]  J. Dickman,et al.  Differential central projections of vestibular afferents in pigeons , 1996, The Journal of comparative neurology.

[12]  S. Vaage.  The segmentation of the primitive neural tube in chick embryos (Gallus domesticus). A morphological, histochemical and autoradiographical investigation. , 1969, Ergebnisse der Anatomie und Entwicklungsgeschichte.

[13]  R. Baker,et al.  Developmental relations between sixth nerve motor neurons and their targets in the chick embryo , 1994, Developmental dynamics : an official publication of the American Association of Anatomists.

[14]  X. Morin,et al.  Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis. , 1997, Development.

[15]  A note on the development of the vestibulo-ocular pathway in the chicken , 2005, Anatomy and Embryology.

[16]  J. A. McConnell.  Identification of early neurons in the brainstem and spinal cord. II. An autoradiographic study in the mouse , 1980, The Journal of comparative neurology.

[17]  J. Glover,et al.  Comparative aspects of the hodological organization of the vestibular nuclear complex and related neuron populations , 2002, Brain Research Bulletin.

[18]  A. Varela-Echavarría,et al.  Differential Expression of LIM Homeobox Genes among Motor Neuron Subpopulations in the Developing Chick Brain Stem , 1996, Molecular and Cellular Neuroscience.