Plasma selenium levels and risk of hepatocellular carcinoma among men with chronic hepatitis virus infection.

Both experimental and epidemiologic studies have linked a low dietary intake of selenium with an increased risk of cancer. The authors examined the association between plasma selenium levels and risk of hepatocellular carcinoma (HCC) among chronic carriers of hepatitis B and/or C virus in a cohort of 7,342 men in Taiwan who were recruited by personal interview and blood draw during 1988-1992. After these men were followed up for an average of 5.3 years, selenium levels in the stored plasma were measured by using hydride atomic absorption spectrometry for 69 incident HCC cases who were positive for hepatitis B surface antigen (HBsAg) and/or antibodies against hepatitis C virus (mostly HBsAg positive) and 139 matched, healthy controls who were HBsAg positive. Mean selenium levels were significantly lower in the HCC cases than in the HBsAg-positive controls (p = 0.01). Adjusted odds ratios of HCC for subjects in increasing quintiles of plasma selenium were 1.00, 0.52, 0.32, 0.19, and 0.62, respectively. The inverse association between plasma selenium levels and HCC was most striking among cigarette smokers and among subjects with low plasma levels of retinol or various carotenoids. There was no clear evidence for an interaction between selenium and alpha-tocopherol in relation to HCC risk.

[1]  C. J. Chen,et al.  Plasma carotenoids, glutathione S-transferase M1 and T1 genetic polymorphisms, and risk of hepatocellular carcinoma: independent and interactive effects. , 1999, American journal of epidemiology.

[2]  C. J. Chen,et al.  Effect of aflatoxin metabolism and DNA adduct formation on hepatocellular carcinoma among chronic hepatitis B carriers in Taiwan. , 1997, Journal of hepatology.

[3]  C. J. Chen,et al.  Prospective study of hepatocellular carcinoma and liver cirrhosis in asymptomatic chronic hepatitis B virus carriers. , 1997, American journal of epidemiology.

[4]  C. Rao,et al.  Chemoprevention of colon cancer by organoselenium compounds and impact of high- or low-fat diets. , 1997, Journal of the National Cancer Institute.

[5]  A. Holmgren,et al.  Selenite and selenate inhibit human lymphocyte growth via different mechanisms. , 1996, Cancer research.

[6]  L W Wang,et al.  Chronic hepatitis B carriers with null genotypes of glutathione S-transferase M1 and T1 polymorphisms who are exposed to aflatoxin are at increased risk of hepatocellular carcinoma. , 1996, American journal of human genetics.

[7]  J. S. Morris,et al.  Prospective study of serum micronutrients and ovarian cancer. , 1996, Journal of the National Cancer Institute.

[8]  C. J. Chen,et al.  Cytochrome P450 2E1 and glutathione S-transferase M1 polymorphisms and susceptibility to hepatocellular carcinoma. , 1995, Gastroenterology.

[9]  W. Willett,et al.  Prospective study of toenail selenium levels and cancer among women. , 1995, Journal of the National Cancer Institute.

[10]  C. J. Chen,et al.  Vegetable consumption, serum retinol level, and risk of hepatocellular carcinoma. , 1995, Cancer research.

[11]  C. J. Chen,et al.  Hepatitis B and C viruses in the development of hepatocellular carcinoma. , 1994, Critical reviews in oncology/hematology.

[12]  C. J. Chen,et al.  Correlations of chronic hepatitis B virus infection and cigarette smoking with elevated expression of neu oncoprotein in the development of hepatocellular carcinoma. , 1994, Cancer research.

[13]  B. Frei.  Natural antioxidants in human health and disease , 1994 .

[14]  R. Goldbohm,et al.  A prospective cohort study on selenium status and the risk of lung cancer. , 1993, Cancer research.

[15]  M. Gail,et al.  Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. , 1993, Journal of the National Cancer Institute.

[16]  R A Goldbohm,et al.  A prospective cohort study on toenail selenium levels and risk of gastrointestinal cancer. , 1993, Journal of the National Cancer Institute.

[17]  C‐J. Chen,et al.  Multiple risk factors of hepatocellular carcinoma: A cohort study of 13 737 male adults in Taiwan , 1993 .

[18]  P. Thuluvath,et al.  Selenium in chronic liver disease. , 1992, Journal of hepatology.

[19]  B. Henderson,et al.  Nonviral risk factors for hepatocellular carcinoma in a low-risk population, the non-Asians of Los Angeles County, California. , 1991, Journal of the National Cancer Institute.

[20]  C. J. Chen,et al.  Association between hepatitis C virus antibodies and hepatocellular carcinoma in Taiwan. , 1991, Cancer research.

[21]  R. J. Turner,et al.  Selenium and the Immune Response , 1991, Proceedings of the Nutrition Society.

[22]  L. Clark,et al.  Selenium in forage crops and cancer mortality in U.S. counties. , 1991, Archives of environmental health.

[23]  R. Peto,et al.  Serum selenium and subsequent risk of cancer among Finnish men and women. , 1990, Journal of the National Cancer Institute.

[24]  A. Tomiak,et al.  An automated microtechnique for selenium determination in human body fluids by flow injection hydride atomic absorption spectrometry (FI-HAAS). , 1990, Journal of trace elements and electrolytes in health and disease.

[25]  S. Hecht,et al.  Advances in Tobacco Carcinogenesis , 1990 .

[26]  R. Coates,et al.  Serum levels of selenium and retinol and the subsequent risk of cancer. , 1988, American journal of epidemiology.

[27]  R. Beasley.  Hepatitis B virus. The major etiology of hepatocellular carcinoma , 1988, Cancer.

[28]  J. S. Morris,et al.  Serum selenium and the risk of cancer, by specific sites: case-control analysis of prospective data. , 1987, Journal of the National Cancer Institute.

[29]  A. Hofman,et al.  Is serum selenium a risk factor for cancer in men only? , 1987, American journal of epidemiology.

[30]  Meir J. Stampfer,et al.  Total energy intake: implications for epidemiologic analyses. , 1986, American journal of epidemiology.

[31]  W. Hoekstra,et al.  Effects of dietary selenium concentration on the development of enzyme-altered liver foci and hepatocellular carcinoma induced by diethylnitrosamine or N-acetylaminofluorene in rats. , 1985, Cancer research.

[32]  W. Hoekstra,et al.  Effects of selenium on cell proliferation in rat liver and mammalian cells as indicated by cytokinetic and biochemical analysis. , 1985, Cancer research.

[33]  Milne Ja.  Effect of selenium on virally induced and transplantable tumor models. , 1985 .

[34]  K. Miller,et al.  An isocratic high-performance liquid chromatography method for the simultaneous analysis of plasma retinol, alpha-tocopherol, and various carotenoids. , 1985, Analytical biochemistry.

[35]  J. Milner.  Effect of selenium on virally induced and transplantable tumor models. , 1985, Federation proceedings.

[36]  W. Willett,et al.  PREDIAGNOSTIC SERUM SELENIUM AND RISK OF CANCER , 1983, The Lancet.

[37]  C. Ip,et al.  Chemoprevention of mammary tumorigenesis by a combined regimen of selenium and vitamin A. , 1981, Carcinogenesis.

[38]  H. Thompson,et al.  Selenium inhibition of N-methyl-N-nitrosourea-induced mammary carcinogenesis in the rat. , 1980, Journal of the National Cancer Institute.

[39]  A. Griffin,et al.  Effect of retinoic acid, butylated hydroxytoluene, selenium and sorbic acid on azo-dye hepatocarcinogenesis. , 1980, Cancer letters.

[40]  A. Griffin.  Role of selenium in the chemoprevention of cancer. , 1979, Advances in cancer research.

[41]  T. S. Matney,et al.  Inhibitory effects of selenium of the mutagenicity of 2-acetylaminofluorene (AAF) and AAF derivatives. , 1977, Cancer letters.

[42]  R. Shamberger,et al.  Antioxidants and cancer. Part VI. Selenium and age-adjusted human cancer mortality. , 1976, Archives of environmental health.

[43]  H. Ganther,et al.  Selenium: Biochemical Role as a Component of Glutathione Peroxidase , 1973, Science.