New platinum-oxicam complexes as anti-cancer drugs. Synthesis, characterization, release studies from smart hydrogels, evaluation of reactivity with selected proteins and cytotoxic activity in vitro.

[1]  D. Neuhaus Nuclear Overhauser Effect , 2011 .

[2]  A. Casini,et al.  Exploring metallodrug–protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compound , 2009, JBIC Journal of Biological Inorganic Chemistry.

[3]  M. Casolaro,et al.  Cisplatin/hydrogel complex in cancer therapy. , 2009, Biomacromolecules.

[4]  H. den Dulk,et al.  Ruthenium polypyridyl complexes and their modes of interaction with DNA: Is there a correlation between these interactions and the antitumor activity of the compounds? , 2008, JBIC Journal of Biological Inorganic Chemistry.

[5]  M. Jakupec,et al.  Water-Soluble Mixed-Ligand Ruthenium(II) and Osmium(II) Arene Complexes with High Antiproliferative Activity , 2008 .

[6]  A. Casini,et al.  Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds. , 2008, Journal of medicinal chemistry.

[7]  H. Sigel,et al.  Comparison of the surprising metal-ion-binding properties of 5- and 6-uracilmethylphosphonate (5Umpa2- and 6Umpa2-) in aqueous solution and crystal structures of the dimethyl and di(isopropyl) esters of H2(6Umpa). , 2008, Chemistry.

[8]  A. Spek,et al.  Synthesis, crystal structure, studies in solution and cytotoxicity of two new fluorescent platinum(II) compounds containing anthracene derivatives as a carrier ligand. , 2008, Inorganic chemistry.

[9]  Ivan Stamenkovic,et al.  Tumor-host interactions: the role of inflammation , 2008, Histochemistry and Cell Biology.

[10]  A. Casini,et al.  Exploiting soft and hard X-ray absorption spectroscopy to characterize metallodrug/protein interactions: the binding of [trans-RuCl4(Im)(dimethylsulfoxide)][ImH] (Im = imidazole) to bovine serum albumin. , 2008, Inorganic chemistry.

[11]  T. Whiteside The tumor microenvironment and its role in promoting tumor growth , 2008, Oncogene.

[12]  M. Casolaro,et al.  Release studies from smart hydrogels as carriers for piroxicam and copper(II)-oxicam complexes as anti-inflammatory and anti-cancer drugs. X-ray structures of new copper(II)-piroxicam and -isoxicam complex molecules. , 2008, Journal of inorganic biochemistry.

[13]  L. Marzilli,et al.  Neglected bidentate sp2 N-donor carrier ligands with triazine nitrogen lone pairs: platinum complexes retromodeling cisplatin guanine nucleobase adducts. , 2008, Inorganic chemistry.

[14]  M. Jakupec,et al.  Synthesis, structure, spectroscopic properties, and antiproliferative activity in vitro of novel osmium(III) complexes with azole heterocycles. , 2008, Inorganic chemistry.

[15]  N. Margiotta,et al.  Conformer distribution in (cis-1,4-DACH)bis(guanosine-5'-phosphate)platinum(II) adducts: a reliable model for DNA adducts of antitumoral cisplatin. , 2008, Inorganic chemistry.

[16]  B. Lippert,et al.  Tetrakis- and tris(1-Methyluracil) complexes of Pt(II): formation and properties of a carbon-bonded nucleobase species as well as of heternonuclear derivatives. , 2007, Inorganic chemistry.

[17]  Michael B Hursthouse,et al.  Unusual coordinating behavior by three non-steroidal anti-inflammatory drugs from the oxicam family towards copper(II). Synthesis, X-ray structure for copper(II)-isoxicam, -meloxicam and -cinnoxicam-derivative complexes, and cytotoxic activity for a copper(II)-piroxicam complex. , 2007, Journal of inorganic biochemistry.

[18]  Jun Li,et al.  Basis Set Exchange: A Community Database for Computational Sciences , 2007, J. Chem. Inf. Model..

[19]  A. Casini,et al.  fac-{Ru(CO)3}2+-core complexes and design of metal-based drugs. synthesis, structure, and reactivity of Ru-thiazole derivative with serum proteins and absorption-release studies with acryloyl and silica hydrogels as carriers in physiological media. , 2007, Inorganic chemistry.

[20]  A. Metters,et al.  Hydrogels in controlled release formulations: network design and mathematical modeling. , 2006, Advanced drug delivery reviews.

[21]  G. Tamasi,et al.  A molecular orbital study of C–H···Cl– and N–H···Cl– hydrogen bonds. Inferences on selected metal complexes and on protein ClC Cl– channels , 2005 .

[22]  R. Gemeinhart,et al.  Cisplatin delivery from poly(acrylic acid-co-methyl methacrylate) microparticles. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[23]  E. Paccagnini,et al.  Stimuli-Responsive Polymers Based on l-Phenylalanine Residues: Protonation Thermodynamics of Free Polymers and Cross-Linked Hydrogels , 2005 .

[24]  Zijian Guo,et al.  Ab initio and density functional theory studies on vibrational spectra of palladium (II) and platinum (II) complexes of methionine and histidine: effect of theoretical methods and basis sets. , 2004, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[25]  L. Messori,et al.  Study of ruthenium(II) complexes with anticancer drugs as ligands. Design of metal-based phototherapeutic agents. , 2003, Inorganic chemistry.

[26]  R. Cini,et al.  Synthesis, X-ray structural characterization and solution studies of metal complexes containing the anti-inflammatory drugs meloxicam and tenoxicam , 2003 .

[27]  M. Calligaris,et al.  Isomerism in the cis-dichloro-tris(dimethyl sulfoxide)(carbonyl)ruthenium(II) complex: a density functional theory investigation , 2003 .

[28]  Anthony L. Spek,et al.  Journal of , 1993 .

[29]  J. Britten,et al.  Model of the most abundant DNA interstrand cross-link of Transplatin: X-ray structures of two modifications and H bonding behavior in the solid state and in solution of trans-[Pt(NH3)2(1-MeC-N3)(9-EtGH-N7)](ClO4)2·nH2O (1-MeC=1-methylcytosine; 9-EtGH=9-ethylguanine) , 2002 .

[30]  R. Cini,et al.  Synthesis, X-ray structure and molecular modelling analysis of cobalt(II), nickel(II), zinc(II) and cadmium(II) complexes of the widely used anti-inflammatory drug meloxicam , 2002 .

[31]  A. Donati,et al.  Synthesis and structural characterization of chloro(2,2′;6′,2″-terpyridine)platinum(II) trichloro(dimethylsulfoxide)platinate(II). Density functional analysis of model molecules , 2001 .

[32]  B. Yates The platinum-ethylene binding energy in Pt(PL 3 ) 2 (C 2 H 4 ) , 2000 .

[33]  R. Cini Anti-Inflammatory Compounds as Ligands in Metal Complexes as Revealed in X-Ray Structural Studies , 2000 .

[34]  Louis J. Farrugia,et al.  WinGX suite for small-molecule single-crystal crystallography , 1999 .

[35]  T. Hambley,et al.  Synthesis, Structure, Biological Activity, and DNA Binding of Platinum(II) Complexes of the Type trans-[PtCl(2)(NH(3))L] (L = Planar Nitrogen Base). Effect of L and Cis/Trans Isomerism on Sequence Specificity and Unwinding Properties Observed in Globally Platinated DNA. , 1999, Inorganic chemistry.

[36]  K. Morokuma,et al.  Molecular orbital study of complexes of zinc(II) with imidazole and water molecules , 1997 .

[37]  A. Cornia,et al.  THE BONDING OF THIAZOLES TO PLATINUM(II) COMPLEXES. X-RAY CRYSTAL STRUCTURE OF CIS- AND TRANS-PT(DIMETHYL SULFOXIDE)(THIAZOLE)CL2 , 1997 .

[38]  David Feller,et al.  The role of databases in support of computational chemistry calculations , 1996, J. Comput. Chem..

[39]  N. Farrell,et al.  Activation of the trans geometry in platinum antitumor complexes. Synthesis, characterization, and biological activity of complexes with the planar ligands pyridine, N-methylimidazole, thiazole and quinoline. Crystal and molecular structure of trans-dichlorobis (thiazole)platinum(II) , 1992 .

[40]  C. Rossi,et al.  Metal complexes of the antiinflammatory drug piroxicam , 1990 .

[41]  F. Dahan,et al.  Complete displacement of N,O bound amino acids (amacH) in cis-[(NH3)2Pt(amac)]NO3 chelates by 9-methylguanine (9-MeGH) and 9-methyladenine (9-MeA). The crystal structure of cis-[(NH3)2Pt(9-meA-N7)2](NO3)2·1.5H2O , 1990 .

[42]  G. Chang,et al.  Macromodel—an integrated software system for modeling organic and bioorganic molecules using molecular mechanics , 1990 .

[43]  David Neuhaus,et al.  The Nuclear Overhauser Effect in Structural and Conformational Analysis , 1989 .

[44]  A. M. Glazer,et al.  A nitrogen‐gas‐stream cryostat for general X‐ray diffraction studies , 1986 .

[45]  Wolfram Saenger,et al.  Principles of Nucleic Acid Structure , 1983 .

[46]  J. Hubert,et al.  Potassium trichloro(dimethyl sulphoxide)platinate(II) , 1976 .

[47]  D. Cremer,et al.  General definition of ring puckering coordinates , 1975 .

[48]  Weiling Zhao,et al.  Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications. , 2009, Current medicinal chemistry.

[49]  M. Swart,et al.  Rare tautomers of 1-methyluracil and 1-methylthymine: tuning relative stabilities through coordination to PtII complexes. , 2009, Chemistry.

[50]  M. Casolaro,et al.  Stimuli-responsive poly(ampholyte)s containing L-histidine residues: synthesis and protonation thermodynamics of methacrylic polymers in the free and in the cross-linked gel forms , 2008 .

[51]  V. Brabec,et al.  DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects , 2008, JBIC Journal of Biological Inorganic Chemistry.

[52]  T. Whiteside,et al.  The role of immune cells in the tumor microenvironment. , 2006, Cancer treatment and research.

[53]  R. Cini,et al.  Synthesis of platinum(II)–piroxicam compounds. Crystal structure of trans-dichloro(η2-ethene)(piroxicam)platinum(II)‡ , 1998 .

[54]  Z. Otwinowski,et al.  [20] Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.

[55]  M. Nardelli,et al.  Parst: A system of fortran routines for calculating molecular structure parameters from results of crystal structure analyses , 1983, Comput. Chem..

[56]  K. Nakamoto Infrared and Raman Spectra of Inorganic and Coordination Compounds , 1978 .

[57]  L. J. Bellamy The infra-red spectra of complex molecules , 1962 .