SIMULTANEOUS MULTI-ELEMENT (INCLUDING FLUORINE) ANALYSIS OF VARIOUS BIO-MEDICAL SAMPLES

We have measured fluorine concentration in samples taken from humans, such as sweat, saliva, snivel and tear in addition to hair, nail and urine, together with those of other elements by means of a three-detector measuring system. Fluorine has been known as one of the most toxic elements as well as arsenic, lead, mercury and cadmium which contaminate environment over the wide area. This system allowed us to discuss about fluorine concentration related to other elements'. A standard-free method established by us has been applied to quantitative analyses of these samples. By means of these methods, quantitative analysis becomes possible for samples of less than 1mg or 1μl and it is quite suited to tear, snivel and sweat. As one of the conclusion, sweat, snivel and tear give useful information in addition to the samples which have been traditionally analyzed. It is found that titanium concentration in a body is well estimated by analyses of sweat, snivel and saliva, arsenic concentration can be estimated by sweat analysis in addition to urine analysis, and nickel is well evaluated by sweat and tear. In this way, it is required to estimate elemental concentration in a human body by measuring various clinical samples. Especially, correlation between fluorine and arsenic is found in a few bio-medical samples.

[1]  K. Sera,et al.  PIXE analysis of hair samples from artisanal mining communities in the Acupan region, Benguet, Philippines , 2004 .

[2]  S. Futatsugawa,et al.  Quantitative analysis of untreated hair samples for monitoring human exposure to heavy metals , 2002 .

[3]  S. Futatsugawa,et al.  PIXE measurement of human hairs from a small-scale mining site of the Philippines , 2002 .

[4]  S. Futatsugawa,et al.  Quantitative analysis of untreated bio-samples , 1999 .

[5]  B. Massonnet,et al.  PIXE analysis of sweat samples: Comparison of sweat secretion in normal and cystic fibrosis children , 1986 .

[6]  K. Sera,et al.  METHOD OF QUANTITATIVE ANALYSIS OF FLUORINE IN ENVIRONMENTAL SAMPLES USING A PURE-Ge DETECTOR , 2004 .

[7]  K. Sera,et al.  A THREE-DETECTOR MEASURING SYSTEM USING A PURE-Ge DETECTOR , 2003 .

[8]  K. Sera,et al.  PIXE ANALYSIS OF HAIR IN ARSENIC POLLUTION, BANGLADESH , 2002 .

[9]  K. Sera,et al.  QUANTITATIVE ANALYSIS OF UNTREATED HUMAN NAILS FOR MONITORING HUMAN EXPOSURE TO HEAVY METALS , 2002 .

[10]  K. Sera,et al.  APPLICATION OF A STANDARD-FREE METHOD TO QUANTITATIVE ANALYSIS OF URINE SAMPLES , 2001 .

[11]  K. Sera,et al.  QUANTITATIVE ANALYSIS OF BIO-MEDICAL SAMPLES OF VERY SMALL QUANTITIES BY THE STANDARD-FREE METHOD , 1997 .

[12]  K. Sera,et al.  STANDARD-FREE METHOD OF QUANTITATIVE ANALYSIS FOR BIO-SAMPLES , 1996 .

[13]  H. Afarideh,et al.  DETERMINATION OF TRACE ELEMENTS IN HUMAN SALIVA BY PIXE TECHNIQUE , 1996 .

[14]  K. Sera,et al.  Bio-PIXE AT THE TAKIZAWA FACILITY (Bio-PIXE WITH A BABY CYCLOTRON) , 1992 .