Analytic expansion of the EEG lead field for realistic volume conductors

EEG forward calculation in realistic volume conductors using the boundary element method suffers from the fact that the solutions become inaccurate for superficial sources. Here we propose to correct an analytical approximation of the respective lead fields with series of spherical harmonics with respect to multiple expansion points. The necessary correction depends very much on the chosen analytical approximation. We constructed the latter such that the correction can be modelled adequately within the chosen basis. Simulations for a 3-shell prolate spheroid demonstrate the accurate modelling of the lead fields. Explicit comparison with analytically known solutions was done for the 3-shell spherical volume conductor showing that relative errors are mostly far below 1% even for the most superficial sources placed directly on the innermost surface.

[1]  E. Frank Electric Potential Produced by Two Point Current Sources in a Homogeneous Conducting Sphere , 1952 .

[2]  D. Geselowitz On bioelectric potentials in an inhomogeneous volume conductor. , 1967, Biophysical journal.

[3]  J. Sarvas Basic mathematical and electromagnetic concepts of the biomagnetic inverse problem. , 1987, Physics in medicine and biology.

[4]  J. D. Munck The potential distribution in a layered anisotropic spheroidal volume conductor , 1988 .

[5]  K. Ueno,et al.  Describing head shape with surface harmonic expansions , 1991, IEEE Transactions on Biomedical Engineering.

[6]  J. D. Munck A linear discretization of the volume conductor boundary integral equation using analytically integrated elements (electrophysiology application) , 1992 .

[7]  G. Fein,et al.  Improved method for computation of potentials in a realistic head shape model , 1995, IEEE Transactions on Biomedical Engineering.

[8]  M. Fuchs,et al.  An improved boundary element method for realistic volume-conductor modeling , 1998, IEEE Transactions on Biomedical Engineering.

[9]  J. Riera,et al.  Electric lead field for a piecewise homogeneous volume conductor model of the head , 1998, IEEE Transactions on Biomedical Engineering.

[10]  R. Leahy,et al.  EEG and MEG: forward solutions for inverse methods , 1999, IEEE Transactions on Biomedical Engineering.

[11]  Johan H. M. Frijns,et al.  Improving the accuracy of the boundary element method by the use of second-order interpolation functions [EEG modeling application] , 2000, IEEE Transactions on Biomedical Engineering.

[12]  Silke Dodel,et al.  Accuracy of Two Dipolar Inverse Algorithms Applying Reciprocity for Forward Calculation , 2000, Comput. Biomed. Res..

[13]  G. Nolte The magnetic lead field theorem in the quasi-static approximation and its use for magnetoencephalography forward calculation in realistic volume conductors. , 2003, Physics in medicine and biology.

[14]  Fetsje Bijma,et al.  In vivo measurement of the brain and skull resistivities using an EIT-based method and realistic models for the head , 2003, IEEE Transactions on Biomedical Engineering.

[15]  S. Tissari,et al.  A precorrected-fFT method to accelerate the solution of the forward problem in magnetoencephalography. , 2003, Physics in medicine and biology.

[16]  F. Kariotou Electroencephalography in ellipsoidal geometry , 2004 .

[17]  Leonid Zhukov,et al.  Lead-field Bases for Electroencephalography Source Imaging , 2000, Annals of Biomedical Engineering.

[18]  Olivier D. Faugeras,et al.  A common formalism for the Integral formulations of the forward EEG problem , 2005, IEEE Transactions on Medical Imaging.

[19]  Fotini Kariotou,et al.  The complete ellipsoidal shell-model in EEG imaging , 2006 .