论文信息 - Selective polymorph transformation via solvent-drop grinding.

Selective polymorph transformation via solvent-drop grinding.

A method of inducing specific polymorph transformations is exemplified with two single-component systems, whereby a given crystal form undergoes conversion when subjected to solid state grinding in the presence of a minor quantity of a certain solvent.

[1] Eric Doelker,et al. Polymorphic Transformation of Some Drugs Under Compression , 1985 .

[2] Joel Bernstein,et al. Polymorphism in Molecular Crystals , 2002 .

[3] J. Mullin,et al. Habit modification of succinic acid crystals grown from different solvents , 1982 .

[4] G. Zografi,et al. Cryogenic grinding of indomethacin polymorphs and solvates: assessment of amorphous phase formation and amorphous phase physical stability. , 2002, Journal of pharmaceutical sciences.

[5] G. Auvert,et al. Hydrogen bond studies. A neutron diffraction study of the structures of succinic acid at 300 and 77 K , 1981 .

[6] M. C. Etter,et al. Polymorphism in anthranilic acid: a reexamination of the phase transitions , 1992 .

[7] Michael J Cima,et al. High-throughput crystallization: polymorphs, salts, co-crystals and solvates of pharmaceutical solids. , 2004, Advanced drug delivery reviews.

[8] M. Ward,et al. Polymorph selectivity under nanoscopic confinement. , 2004, Journal of the American Chemical Society.

[9] P. W. Carter,et al. Directing Polymorph Selectivity During Nucleation of Anthranilic Acid on Molecular Substrates , 1994 .

[10] M. D. de Villiers,et al. Structural characterization, physicochemical properties, and thermal stability of three crystal forms of nifedipine. , 2003, Journal of pharmaceutical sciences.