Building a Group-Based Opioid Treatment (GBOT) blueprint: a qualitative study delineating GBOT implementation

BackgroundGroup-Based Opioid Treatment (GBOT) has recently emerged as a mechanism for treating patients with opioid use disorder (OUD) in the outpatient setting. However, the more practical “how to” components of successfully delivering GBOT has received little attention in the medical literature, potentially limiting its widespread implementation and utilization. Building on a previous case series, this paper delineates the key components to implementing GBOT by asking: (a) What are the core components to GBOT implementation, and how are they defined? (b) What are the malleable components to GBOT implementation, and what conceptual framework should providers use in determining how to apply these components for effective delivery in their unique clinical environment?MethodsTo create a blueprint delineating GBOT implementation, we integrated findings from a previously conducted and separately published systematic review of existing GBOT studies, conducted additional literature review, reviewed best practice recommendations and policies related to GBOT and organizational frameworks for implementing health systems change. We triangulated this data with a qualitative thematic analysis from 5 individual interviews and 2 focus groups representing leaders from 5 different GBOT programs across our institution to identify the key components to GBOT implementation, distinguish “core” and “malleable” components, and provide a conceptual framework for considering various options for implementing the malleable components.ResultsWe identified 6 core components to GBOT implementation that optimize clinical outcomes, comply with mandatory policies and regulations, ensure patient and staff safety, and promote sustainability in delivery. These included consistent group expectations, team-based approach to care, safe and confidential space, billing compliance, regular monitoring, and regular patient participation. We identified 14 malleable components and developed a novel conceptual framework that providers can apply when deciding how to employ each malleable component that considers empirical, theoretical and practical dimensions.ConclusionWhile further research on the effectiveness of GBOT and its individual implementation components is needed, the blueprint outlined here provides an initial framework to help office-based opioid treatment sites implement a successful GBOT approach and hence potentially serve as future study sites to establish efficacy of the model. This blueprint can also be used to continuously monitor how components of GBOT influence treatment outcomes, providing an empirical framework for the ongoing process of refining implementation strategies.

[1]  D. Bloch,et al.  A meta-analysis comparing buprenorphine to methadone for treatment of opiate dependence. , 2001, Addiction.

[2]  T. L. La Salvia Enhancing addiction treatment through psychoeducational groups. , 1993, Journal of substance abuse treatment.

[3]  G. Badger,et al.  Alternate-day dosing during buprenorphine treatment of opioid dependence. , 1994, Life sciences.

[4]  Albert Dahan,et al.  Current Knowledge of Buprenorphine and Its Unique Pharmacological Profile , 2010, Pain practice : the official journal of World Institute of Pain.

[5]  W. Ling,et al.  Buprenorphine maintenance treatment of opiate dependence: a multicenter, randomized clinical trial. , 1998, Addiction.

[6]  E. Khantzian Group Psychotherapy with Addicted Populations , 1989 .

[7]  Lorelei Lingard,et al.  Critically appraising qualitative research , 2008, BMJ : British Medical Journal.

[8]  Tim Swanwick,et al.  Understanding Medical Education: Evidence, Theory and Practice, 1st edn , 2011 .

[9]  Aziz Sheikh,et al.  The case study approach , 2011, BMC medical research methodology.

[10]  T. Bickmore,et al.  Design of the integrative medical group visits randomized control trial for underserved patients with chronic pain and depression. , 2017, Contemporary clinical trials.

[11]  Michael E. Levin,et al.  An initial meta-analysis of Acceptance and Commitment Therapy for treating substance use disorders. , 2015, Drug and alcohol dependence.

[12]  N. Lee,et al.  A systematic review of interventions for co-occurring substance use and borderline personality disorders. , 2015, Drug and alcohol review.

[13]  J. Hennen,et al.  A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence. , 2007, The American journal of psychiatry.

[14]  N. Petry,et al.  Contingency management delivered by community therapists in outpatient settings. , 2012, Drug and alcohol dependence.

[15]  Dennis M. Donovan,et al.  Relapse prevention: Maintenance strategies in the treatment of addictive behaviors, 2nd ed. , 2005 .

[16]  S. Sonne,et al.  Adjunctive counseling during brief and extended buprenorphine-naloxone treatment for prescription opioid dependence: a 2-phase randomized controlled trial. , 2011, Archives of general psychiatry.

[17]  Bridget C. O’Brien,et al.  Standards for Reporting Qualitative Research: A Synthesis of Recommendations , 2014, Academic medicine : journal of the Association of American Medical Colleges.

[18]  E. Yano,et al.  Implementation Science BioMed Central Methodology The role of organizational research in implementing evidence-based practice: QUERI Series , 2006 .

[19]  Modeling longitudinal data from a rolling therapy group program with membership turnover: Does group culture affect individual alliance? , 2010 .

[20]  M. Hurford,et al.  Appropriate Use of Drug Testing in Clinical Addiction Medicine , 2017, Journal of addiction medicine.

[21]  R. Barkin,et al.  Sublingual Buprenorphine Is Effective in the Treatment of Chronic Pain Syndrome , 2005, American journal of therapeutics.

[22]  R. Weiss,et al.  The Role of Psychotherapy in the Treatment of Substance‐Use Disorders , 1994, Harvard review of psychiatry.

[23]  Matching Alcoholism Treatments to Client Heterogeneity: Project MATCH posttreatment drinking outcomes. , 1997, Journal of studies on alcohol.

[24]  G. Woody,et al.  Predictors of buprenorphine-naloxone dosing in a 12-week treatment trial for opioid-dependent youth: secondary analyses from a NIDA Clinical Trials Network study. , 2010, Drug and alcohol dependence.

[25]  S. Wakeman,et al.  Patient experiences with a transitional, low-threshold clinic for the treatment of substance use disorder: A qualitative study of a bridge clinic. , 2019, Journal of substance abuse treatment.

[26]  Ayman Fareed,et al.  Effect of Buprenorphine Dose on Treatment Outcome , 2012, Journal of addictive diseases.

[27]  K. Preston,et al.  Improvement in naltrexone treatment compliance with contingency management. , 1999, Drug and alcohol dependence.

[28]  Samantha J Lookatch,et al.  Clinician-delivered contingency management increases engagement and attendance in drug and alcohol treatment. , 2015, Drug and alcohol dependence.

[29]  M. Linehan,et al.  Treating co-occurring Axis I disorders in recurrently suicidal women with borderline personality disorder: a 2-year randomized trial of dialectical behavior therapy versus community treatment by experts. , 2008, Journal of consulting and clinical psychology.

[30]  J. Salvendy Ethnocultural considerations in group psychotherapy. , 1999, International journal of group psychotherapy.

[31]  Thomas A. La Salvia Enhancing addiction treatment through psychoeducational groups , 1993 .

[32]  Natalie Crino,et al.  Cohesion to the group and its association with attendance and early treatment response in an adult day‐hospital program for eating disorders: A preliminary clinical investigation , 2010 .

[33]  G. Aronoff,et al.  Recommendations for urine drug monitoring as a component of opioid therapy in the treatment of chronic pain. , 2012, Pain medicine.

[34]  Linda A. Dimeff,et al.  Dialectical Behavior Therapy for Substance Abusers , 2008, Addiction science & clinical practice.

[35]  G. Scambler Stigma and disease: changing paradigms , 1998, The Lancet.

[36]  T. Bodenheimer,et al.  Team Structure and Culture Are Associated With Lower Burnout in Primary Care , 2014, The Journal of the American Board of Family Medicine.

[37]  R. Rosenthal,et al.  A LONGITUDINAL STUDY OF THE EFFECTS OF EXPERIMENTER BIAS ON THE OPERANT LEARNING OF LABORATORY RATS. , 1964, Journal of psychiatric research.

[38]  A. Washton,et al.  Relapse Prevention: Maintenance Strategies in the Treatment of Addictive Behaviors , 1986 .

[39]  Declan T. Barry,et al.  Primary care-based buprenorphine taper vs maintenance therapy for prescription opioid dependence: a randomized clinical trial. , 2014, JAMA internal medicine.

[40]  Stephen A. Martin,et al.  The Next Stage of Buprenorphine Care for Opioid Use Disorder , 2018, Annals of Internal Medicine.

[41]  M. Greenwald,et al.  Buprenorphine maintenance and mu-opioid receptor availability in the treatment of opioid use disorder: implications for clinical use and policy. , 2014, Drug and alcohol dependence.

[42]  R. Rosenblatt,et al.  Barriers to Primary Care Physicians Prescribing Buprenorphine , 2014, The Annals of Family Medicine.

[43]  Siu Ping Chin Feman,et al.  Feasibility of Implementing Shared Medical Appointments (SMAs) for Office-Based Opioid Treatment with Buprenorphine: A Pilot Study , 2015, Substance abuse.

[44]  Neurophysiological mechanisms in acceptance and commitment therapy in opioid-addicted patients with chronic pain , 2016, Psychiatry Research: Neuroimaging.

[45]  B. Adinoff,et al.  Disseminating contingency management to increase attendance in two community substance abuse treatment centers: lessons learned. , 2010, Journal of substance abuse treatment.

[46]  Thomas Bodenheimer,et al.  Estimating a Reasonable Patient Panel Size for Primary Care Physicians With Team-Based Task Delegation , 2012, The Annals of Family Medicine.

[47]  G. Badger,et al.  Computerized behavior therapy for opioid-dependent outpatients: a randomized controlled trial. , 2008, Experimental and clinical psychopharmacology.

[48]  Karin A Mack,et al.  Pharmaceutical overdose deaths, United States, 2010. , 2013, JAMA.

[49]  G. Koob,et al.  Brain stress systems in the amygdala and addiction , 2009, Brain Research.

[50]  K. Sher,et al.  The relation of treatment fearfulness and psychological service utilization: an overview , 1991 .

[51]  W. Bickel,et al.  Adding an Internet-delivered treatment to an efficacious treatment package for opioid dependence. , 2014, Journal of consulting and clinical psychology.

[52]  F. Davidoff On the undiffusion of established practices. , 2015, JAMA internal medicine.

[53]  W. Ling,et al.  Participant Characteristics and Buprenorphine Dose , 2011, The American journal of drug and alcohol abuse.

[54]  R. Gallop,et al.  The Women's Recovery Group Study: a Stage I trial of women-focused group therapy for substance use disorders versus mixed-gender group drug counseling. , 2007, Drug and alcohol dependence.

[55]  C. Cunningham,et al.  Attending physicians' and residents' attitudes and beliefs about prescribing buprenorphine at an urban teaching hospital. , 2006, Family medicine.

[56]  F. Levin,et al.  Unobserved versus observed office buprenorphine/naloxone induction: a pilot randomized clinical trial. , 2010, Addictive behaviors.

[57]  Duncan Stewart,et al.  Attendance at Narcotics Anonymous and Alcoholics Anonymous meetings, frequency of attendance and substance use outcomes after residential treatment for drug dependence: a 5-year follow-up study. , 2008, Addiction.

[58]  James D. Griffith,et al.  Contingency management in outpatient methadone treatment: a meta-analysis. , 2000, Drug and alcohol dependence.

[59]  K. Carroll,et al.  Randomized Pilot Trial of Web-Based Cognitive-Behavioral Therapy Adapted for Use in Office-Based Buprenorphine Maintenance , 2019, Substance abuse.

[60]  C. Grella,et al.  Women in Residential Drug Treatment: Differences by Program Type and Pregnancy , 1999, Journal of health care for the poor and underserved.

[61]  L. Najavits,et al.  A New Gender-Based Model for Women's Recovery From Substance Abuse: Results of a Pilot Outcome Study , 2007, The American journal of drug and alcohol abuse.

[62]  E. Schoener,et al.  Brief Intervention in Hazardous Drinking: An Important Adjunct to Medical School ATOD Curriculum , 1998, Substance abuse.

[63]  J. Zibbell,et al.  Increases in Drug and Opioid Overdose Deaths—United States, 2000–2014 , 2016, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[64]  Zev Schuman-Olivier,et al.  Clinician beliefs and attitudes about buprenorphine/naloxone diversion. , 2013, The American journal on addictions.

[65]  P. Curșeu,et al.  The magic of collective emotional intelligence in learning groups: No guys needed for the spell! , 2015, British journal of psychology.

[66]  Zev Schuman-Olivier,et al.  Why use Group Visits for Opioid use Disorder Treatment in Primary Care? A Patient-Centered Qualitative Study , 2018, Substance abuse.

[67]  L. Nelson-Zlupko,et al.  Women in recovery. Their perceptions of treatment effectiveness. , 1996, Journal of substance abuse treatment.

[68]  Zev Schuman-Olivier,et al.  Emerging adult age status predicts poor buprenorphine treatment retention. , 2014, Journal of substance abuse treatment.

[69]  Robert A Koeppe,et al.  Buprenorphine-Induced Changes in Mu-Opioid Receptor Availability in Male Heroin-Dependent Volunteers: A Preliminary Study , 2000, Neuropsychopharmacology.

[70]  L. Manchikanti,et al.  Urine drug testing in chronic pain. , 2011, Pain physician.

[71]  A. Donabedian The definition of quality and approaches to its assessment , 1980 .

[72]  H Schmidt,et al.  Dialectical behavior therapy for patients with borderline personality disorder and drug-dependence. , 1999, The American journal on addictions.

[73]  H. Connery Medication-Assisted Treatment of Opioid Use Disorder: Review of the Evidence and Future Directions , 2015, Harvard review of psychiatry.

[74]  Zev Schuman-Olivier,et al.  Group-based treatment of opioid use disorder with buprenorphine: A systematic review. , 2018, Journal of substance abuse treatment.

[75]  R. Sinha,et al.  Contingency management to enhance naltrexone treatment of opioid dependence: a randomized clinical trial of reinforcement magnitude. , 2002, Experimental and clinical psychopharmacology.

[76]  Zev Schuman-Olivier,et al.  Mindfulness Training Enhances Self-Regulation and Facilitates Health Behavior Change for Primary Care Patients: a Randomized Controlled Trial , 2018, Journal of General Internal Medicine.

[77]  L. Manchikanti,et al.  Does random urine drug testing reduce illicit drug use in chronic pain patients receiving opioids? , 2006, Pain physician.

[78]  W. Miller,et al.  Is low therapist empathy toxic? , 2013, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[79]  J. Samet,et al.  Office-Based Opioid Treatment with Buprenorphine (OBOT-B): Statewide Implementation of the Massachusetts Collaborative Care Model in Community Health Centers. , 2016, Journal of substance abuse treatment.

[80]  Rebecca E. Lee,et al.  Improving Participation Rates for Women of Color in Health Research: The Role of Group Cohesion , 2012, Prevention Science.

[81]  Sarah E. Nelson,et al.  Self-treatment: illicit buprenorphine use by opioid-dependent treatment seekers. , 2010, Journal of substance abuse treatment.

[82]  Lori J. Ducharme,et al.  Clinical supervision, emotional exhaustion, and turnover intention: a study of substance abuse treatment counselors in the Clinical Trials Network of the National Institute on Drug Abuse. , 2008, Journal of substance abuse treatment.

[83]  Judith Good,et al.  Strategy, team cohesion and team member satisfaction: The effects of gender and group composition , 2015, Comput. Hum. Behav..

[84]  W. Ling,et al.  Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone. , 2003, The New England journal of medicine.

[85]  Anke Medrington What’s in a name? , 2008, BMJ : British Medical Journal.

[86]  W. Bickel,et al.  Effect of methadone dose contingencies on urinalysis test results of polydrug-abusing methadone-maintenance patients. , 1986, Drug and alcohol dependence.

[87]  L. Felch,et al.  Contingent take-home incentive: effects on drug use of methadone maintenance patients. , 1992, Journal of consulting and clinical psychology.

[88]  H. Shaffer,et al.  Benzodiazepine use during buprenorphine treatment for opioid dependence: clinical and safety outcomes. , 2013, Drug and alcohol dependence.

[89]  L. Rubenstein,et al.  Strategies for promoting organizational and practice change by advancing implementation research , 2006, Journal of General Internal Medicine.

[90]  F. Vocci,et al.  Unobserved “Home” Induction Onto Buprenorphine , 2014, Journal of addiction medicine.

[91]  M. Stitzer,et al.  A placebo controlled clinical trial of buprenorphine as a treatment for opioid dependence. , 1995, Drug and alcohol dependence.

[92]  D. Festinger,et al.  Prize-based contingency management for the treatment of substance abusers: a meta-analysis. , 2014, Addiction.

[93]  P. Glider,et al.  Women residents: expanding their role to increase treatment effectiveness in substance abuse programs. , 1989, The International journal of the addictions.

[94]  J. Strang,et al.  Contingency Management interventions for non-prescribed drug use during treatment for opiate addiction: A systematic review and meta-analysis , 2017, Drug and alcohol dependence.

[95]  A. Washton Psychotherapy and substance abuse : a practitioner's handbook , 1995 .

[96]  Hsiu-Fang Hsieh,et al.  Three Approaches to Qualitative Content Analysis , 2005, Qualitative health research.

[97]  S. Caritis,et al.  An evidence‐based recommendation to increase the dosing frequency of buprenorphine during pregnancy , 2017, American journal of obstetrics and gynecology.

[98]  Jennifer E. Johnson,et al.  Process predictors of the outcome of group drug counseling. , 2013, Journal of consulting and clinical psychology.

[99]  B. Saloner,et al.  Moving Addiction Care to the Mainstream - Improving the Quality of Buprenorphine Treatment. , 2018, The New England journal of medicine.

[100]  G A Marlatt,et al.  Harm reduction: come as you are. , 1996, Addictive behaviors.

[101]  August F. Holtyn,et al.  Effects of incentives for naltrexone adherence on opiate abstinence in heroin‐dependent adults , 2017, Addiction.

[102]  B. Rounsaville,et al.  Targeting behavioral therapies to enhance naltrexone treatment of opioid dependence: efficacy of contingency management and significant other involvement. , 2001, Archives of general psychiatry.

[103]  Zac E. Imel,et al.  Distinctions without a difference: direct comparisons of psychotherapies for alcohol use disorders. , 2008, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[104]  Randi Sokol,et al.  Implementing Group Visits for Opioid Use Disorder: A Case Series , 2019, Substance abuse.

[105]  L. Dimeff,et al.  Dialectical behavior therapy versus comprehensive validation therapy plus 12-step for the treatment of opioid dependent women meeting criteria for borderline personality disorder. , 2002, Drug and alcohol dependence.

[106]  T. Killeen,et al.  Effect of prize-based incentives on outcomes in stimulant abusers in outpatient psychosocial treatment programs: a national drug abuse treatment clinical trials network study. , 2005, Archives of general psychiatry.

[107]  N. Ronel,et al.  Can a 12-Step Program Work in Methadone Maintenance Treatment? , 2011, International journal of offender therapy and comparative criminology.

[108]  P. Friedmann,et al.  Buprenorphine retention in primary care. , 2005, Journal of general internal medicine.

[109]  B. Anderson,et al.  Initiating buprenorphine treatment for opioid use disorder during short-term in-patient 'detoxification': a randomized clinical trial. , 2019, Addiction.

[110]  H. Shulha,et al.  High‐intensity cannabis use is associated with retention in opioid agonist treatment: a longitudinal analysis , 2018, Addiction.

[111]  N. Petry,et al.  Effects of lower-cost incentives on stimulant abstinence in methadone maintenance treatment: a National Drug Abuse Treatment Clinical Trials Network study. , 2006, Archives of general psychiatry.

[112]  M. Heilig,et al.  1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial , 2003, The Lancet.

[113]  C. Oser,et al.  Causes, Consequences, and Prevention of Burnout Among Substance Abuse Treatment Counselors: A Rural Versus Urban Comparison , 2013, Journal of psychoactive drugs.

[114]  Linda M. Martin,et al.  Effectiveness of a peer-support community in addiction recovery: participation as intervention. , 2008, Occupational therapy international.

[115]  Internal validity of Project MATCH treatments: discriminability and integrity. , 1998, Journal of consulting and clinical psychology.

[116]  Maria Di Blasi,et al.  The Influence of Retention, Turnover, and Alliance on Process and Outcomes in Rolling Group Psychotherapy for Cocaine Disorder , 2016, International journal of group psychotherapy.

[117]  R. Koeppe,et al.  Buprenorphine Duration of Action: Mu-opioid Receptor Availability and Pharmacokinetic and Behavioral Indices , 2007, Biological Psychiatry.

[118]  L. Lingard,et al.  Qualitative Research Methods in Medical Education , 2010 .

[119]  Jo Rycroft-Malone,et al.  Nursing Theory and Concept Development or Analysis Getting Evidence into Practice: the Meaning of 'context' , 2022 .

[120]  M. Freimuth Integrating Group Psychotherapy and 12-Step Work: A Collaborative Approach , 2000, International journal of group psychotherapy.

[121]  Katie Witkiewitz,et al.  Relapse prevention for addictive behaviors , 2011, Substance abuse treatment, prevention, and policy.

[122]  B. Druss,et al.  Racial/ethnic differences in treatment for substance use disorders among U.S. adolescents. , 2011, Journal of the American Academy of Child and Adolescent Psychiatry.

[123]  K. Carroll,et al.  The Role of Behavioral Interventions in Buprenorphine Maintenance Treatment: A Review. , 2017, The American journal of psychiatry.

[124]  Bethany J Figg,et al.  Substance Abuse and Mental Health Services Administration , 2018, Journal of Consumer Health on the Internet.

[125]  R P Mattick,et al.  Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence. , 2009, The Cochrane database of systematic reviews.

[126]  K. Kampman,et al.  American Society of Addiction Medicine (ASAM) National Practice Guideline for the Use of Medications in the Treatment of Addiction Involving Opioid Use , 2015, Journal of addiction medicine.

[127]  C. Barrowclough,et al.  The role of the therapeutic alliance in the treatment of substance misuse: a critical review of the literature. , 2005, Addiction.

[128]  J. Hennen,et al.  A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence. , 2007, The American journal of psychiatry.

[129]  S. Caritis,et al.  Dose‐adjusted plasma concentrations of sublingual buprenorphine are lower during than after pregnancy , 2017, American journal of obstetrics and gynecology.

[130]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..

[131]  J. Trafton,et al.  The effect of stress on craving for methadone depends on the timing of last methadone dose. , 2008, Behaviour research and therapy.

[132]  J. Jaffe,et al.  Use of buprenorphine in the treatment of opioid addiction. II. Physiologic and behavioral effects of daily and alternate‐day administration and abrupt withdrawal , 1990, Clinical pharmacology and therapeutics.

[133]  T. Kosten,et al.  Methadone versus buprenorphine with contingency management or performance feedback for cocaine and opioid dependence. , 2005, The American journal of psychiatry.

[134]  A. Huhn,et al.  Why aren't physicians prescribing more buprenorphine? , 2017, Journal of substance abuse treatment.

[135]  Sarah Bowen,et al.  Relative efficacy of mindfulness-based relapse prevention, standard relapse prevention, and treatment as usual for substance use disorders: a randomized clinical trial. , 2014, JAMA psychiatry.

[136]  M. Godley,et al.  Adolescent Community Reinforcement Approach implementation and treatment outcomes for youth with opioid problem use. , 2017, Drug and alcohol dependence.

[137]  I. Yalom,et al.  The Theory and Practice of Group Psychotherapy , 1971, Mental Health.

[138]  Declan T. Barry,et al.  Experiences of Burnout among Drug Counselors in A Large Opioid Treatment Program: A Qualitative Investigation , 2018, Substance abuse.

[139]  M. Stitzer,et al.  Contingency management in a methadone maintenance program: availability of reinforcers. , 1978, The International journal of the addictions.

[140]  J. Havens,et al.  Inability to access buprenorphine treatment as a risk factor for using diverted buprenorphine. , 2012, Drug and alcohol dependence.