Sex as a determinant of type 1 diabetes at diagnosis

The present study tested the hypothesis that girls have a more aggressive disease process than boys at the diagnosis of type 1 diabetes (T1D).

[1]  K. Reimer,et al.  Type 1 diabetes incidence and prevalence trends in a cohort of Canadian children and youth , 2018, Pediatric diabetes.

[2]  J. Ilonen,et al.  Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity , 2018, Pediatric diabetes.

[3]  A. Bideci,et al.  Prevalence of ZnT8 Antibody in Turkish Children and Adolescents with New Onset Type 1 Diabetes , 2017, Journal of clinical research in pediatric endocrinology.

[4]  Å. Lernmark,et al.  The Influence of Type 1 Diabetes Genetic Susceptibility Regions, Age, Sex, and Family History on the Progression From Multiple Autoantibodies to Type 1 Diabetes: A TEDDY Study Report , 2017, Diabetes.

[5]  M. Rewers,et al.  Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes Predicts Poor Long-term Glycemic Control , 2017, Diabetes Care.

[6]  B. Barton,et al.  A predictive model for lack of partial clinical remission in new-onset pediatric type 1 diabetes , 2017, PloS one.

[7]  J. Ilonen,et al.  The association of the HLA‐A*24:02, B*39:01 and B*39:06 alleles with type 1 diabetes is restricted to specific HLA‐DR/DQ haplotypes in Finns , 2017, HLA.

[8]  H. Siljander,et al.  Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility , 2017, Diabetologia.

[9]  S. Gudbjörnsdottir,et al.  Teenage girls with type 1 diabetes have poorer metabolic control than boys and face more complications in early adulthood. , 2016, Journal of diabetes and its complications.

[10]  J. Ilonen,et al.  Genetic susceptibility to type 1 diabetes in childhood – estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity , 2016, Pediatric diabetes.

[11]  L. Hanberger,et al.  The influence of age, gender, insulin dose, BMI, and blood pressure on metabolic control in young patients with type 1 diabetes , 2015, Pediatric diabetes.

[12]  L. Hanberger,et al.  Glycated haemoglobin variations in paediatric type 1 diabetes: the impact of season, gender and age , 2014, Acta paediatrica.

[13]  J. Ilonen,et al.  Autoantibodies against zinc transporter 8 are related to age, metabolic state and HLA DR genotype in children with newly diagnosed type 1 diabetes , 2013, Diabetes/metabolism research and reviews.

[14]  J. Ilonen,et al.  Extended Family History of Type 1 Diabetes and Phenotype and Genotype of Newly Diagnosed Children , 2013, Diabetes Care.

[15]  Å. Lernmark,et al.  Residual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season , 2013, Diabetes/metabolism research and reviews.

[16]  E. Bonifacio,et al.  Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes , 2012, Diabetologia.

[17]  S. Sharp,et al.  Factors associated with the presence of diabetic ketoacidosis at diagnosis of diabetes in children and young adults: a systematic review , 2011, BMJ : British Medical Journal.

[18]  L. Dimeglio,et al.  The utility of hemoglobin A1c at diagnosis for prediction of future glycemic control in children with type 1 diabetes. , 2011, Diabetes research and clinical practice.

[19]  G. Eisenbarth,et al.  A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes , 2008, Diabetes.

[20]  J. Rosenbauer,et al.  Metabolic control as reflectet by HbA1c in children, adolescents and young adults with type-1 diabetes mellitus: combined longitudinal analysis including 27,035 patients from 207 centers in Germany and Austria during the last decade , 2008, European Journal of Pediatrics.

[21]  J. Tuomilehto,et al.  Incidence and trends of childhood Type 1 diabetes worldwide 1990–1999 , 2006, Diabetic medicine : a journal of the British Diabetic Association.

[22]  J. Ilonen,et al.  Dynamics of diabetes-associated autoantibodies in young children with human leukocyte antigen-conferred risk of type 1 diabetes recruited from the general population. , 2005, The Journal of clinical endocrinology and metabolism.

[23]  J. Krischer,et al.  Male sex increases the risk of autoimmunity but not type 1 diabetes. , 2004, Diabetes care.

[24]  L. Nyström,et al.  Male predominance of Type 1 (insulin-dependent) diabetes mellitus in young adults: results from a 5-year prospective nationwide study of the 15–34-year age group in Sweden , 2004, Diabetologia.

[25]  P. Bingley,et al.  The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence , 2003, Diabetologia.

[26]  J. Ilonen,et al.  Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes. , 2002, American journal of medical genetics.

[27]  P. Bingley,et al.  Islet autoantibodies, nationality and gender: a multinational screening study in first-degree relatives of patients with Type I diabetes , 2002, Diabetologia.

[28]  P. Pozzilli,et al.  Is the process of beta-cell destruction in type 1 diabetes at time of diagnosis more extensive in females than in males? , 2001, European journal of endocrinology.

[29]  E. Gale,et al.  Diabetes and gender , 2001, Diabetologia.

[30]  C. Cobelli,et al.  Pubertal Adolescent Male-Female Differences in Insulin Sensitivity and Glucose Effectiveness Determined by the One Compartment Minimal Model , 2000, Pediatric Research.

[31]  J. Tuomilehto,et al.  Worldwide increase in incidence of Type I diabetes – the analysis of the data on published incidence trends , 1999, Diabetologia.

[32]  M. Knip,et al.  Diabetes-associated autoantibodies in relation to clinical characteristics and natural course in children with newly diagnosed type 1 diabetes. The Childhood Diabetes In Finland Study Group. , 1999, The Journal of clinical endocrinology and metabolism.

[33]  J. Ilonen,et al.  Disease‐associated autoantibodies and HLA‐DQB1 genotypes in children with newly diagnosed insulin‐dependent diabetes mellitus (IDDM) , 1999, Clinical and experimental immunology.

[34]  C. Berne,et al.  Factors predicting clinical remission in adult patients with type 1 diabetes , 1999, Journal of internal medicine.

[35]  M. Knip,et al.  Prepubertal girls with insulin-dependent diabetes mellitus have higher exogenous insulin requirement than boys , 1998, European Journal of Pediatrics.

[36]  E. Bonifacio,et al.  IA-2 antibodies – a sensitive marker of IDDM with clinical onset in childhood and adolescence , 1998, Diabetologia.

[37]  J. Tuomilehto,et al.  Sex difference in the incidence of insulin-dependent diabetes mellitus: an analysis of the recent epidemiological data. World Health Organization DIAMOND Project Group. , 1997, Diabetes/metabolism reviews.

[38]  Å. Lernmark,et al.  Age governs gender‐dependent islet cell autoreactivity and predicts the clinical course in childhood IDDM , 1997, Acta paediatrica.

[39]  J. Ludvigsson,et al.  Autoantibodies in relation to residual insulin secretion in children with IDDM. , 1997, Diabetes research and clinical practice.

[40]  M. Knip,et al.  Glutamic acid decarboxylase antibodies in relation to other autoantibodies and genetic risk markers in children with newly diagnosed insulin-dependent diabetes. Childhood Diabetes in Finland Study Group. , 1996, The Journal of clinical endocrinology and metabolism.

[41]  D. Becker,et al.  Sexual dimorphism in insulin sensitivity in adolescents with insulin-dependent diabetes mellitus. , 1991, The Journal of clinical endocrinology and metabolism.

[42]  K. W. Backe,et al.  [In the children's hospital]. , 1984, Krankenpflege Journal.

[43]  M. Knip,et al.  POSTINITIAL REMISSION IN DIABETIC CHILDREN– AN ANALYSIS OF 178 CASES , 1982, Acta paediatrica Scandinavica.

[44]  D. Doniach,et al.  Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. , 1974, Lancet.