The cell-death machine

[1]  D. Danley,et al.  D4-GDI, a Substrate of CPP32, Is Proteolyzed during Fas-induced Apoptosis (*) , 1996, Journal of Biological Chemistry.

[2]  G. Salvesen,et al.  Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[3]  X. Wang,et al.  Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. , 1996, The EMBO journal.

[4]  A. Chinnaiyan,et al.  Molecular Ordering of the Cell Death Pathway , 1996, The Journal of Biological Chemistry.

[5]  A. Chinnaiyan,et al.  FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis (*) , 1996, The Journal of Biological Chemistry.

[6]  J. Trapani,et al.  Localization of Granzyme B in the Nucleus , 1996, The Journal of Biological Chemistry.

[7]  J. Mankovich,et al.  Protease Activity of in Vitro Transcribed and Translated Caenorhabditis elegans Cell Death Gene (ced-3) Product (*) , 1996, The Journal of Biological Chemistry.

[8]  P. Amiri,et al.  Requirement of an ICE-Like Protease for Induction of Apoptosis and Ceramide Generation by REAPER , 1996, Science.

[9]  H. Steller,et al.  Cell Killing by the Drosophila Gene reaper , 1996, Science.

[10]  E. Cheng,et al.  Bax-independent inhibition of apoptosis by Bcl-XL , 1996, Nature.

[11]  S. Farrow,et al.  New members of the Bcl-2 family and their protein partners. , 1996, Current opinion in genetics & development.

[12]  M. Hengartner Programmed cell death in invertebrates. , 1996, Current opinion in genetics & development.

[13]  M. Jäättelä,et al.  A20 zinc finger protein inhibits TNF and IL-1 signaling. , 1996, Journal of immunology.

[14]  P. Branton,et al.  Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase. , 1996, Oncogene.

[15]  Hong-Bing Shu,et al.  TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways , 1996, Cell.

[16]  P. Caron,et al.  Identification and Characterization of CPP32/Mch2 Homolog 1, a Novel Cysteine Protease Similar to CPP32 (*) , 1996, The Journal of Biological Chemistry.

[17]  S. Orrenius,et al.  CPP32/Apopain Is a Key Interleukin 1 Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis (*) , 1996, The Journal of Biological Chemistry.

[18]  K. Tamai,et al.  Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes , 1996, Nature.

[19]  A. Chinnaiyan,et al.  ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis (*) , 1996, The Journal of Biological Chemistry.

[20]  Gerald M. Rubin,et al.  Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death , 1995, Cell.

[21]  Mike Rothe,et al.  The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins , 1995, Cell.

[22]  E. Alnemri,et al.  Mch3, a novel human apoptotic cysteine protease highly related to CPP32. , 1995, Cancer research.

[23]  R. Moyer,et al.  A rabbitpox virus serpin gene controls host range by inhibiting apoptosis in restrictive cells , 1995, Journal of virology.

[24]  R. Weichselbaum,et al.  Proteolytic activation of protein kinase C delta by an ICE‐like protease in apoptotic cells. , 1995, The EMBO journal.

[25]  Sharad Kumar,et al.  Role of multiple cellular proteases in the execution of programmed cell death , 1995, FEBS letters.

[26]  M. Peter,et al.  Cytotoxicity‐dependent APO‐1 (Fas/CD95)‐associated proteins form a death‐inducing signaling complex (DISC) with the receptor. , 1995, The EMBO journal.

[27]  J. Weidner,et al.  The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy , 1995, The Journal of experimental medicine.

[28]  D. Nicholson,et al.  Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B , 1995, Nature.

[29]  J. Mankovich,et al.  Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. , 1995, Science.

[30]  Y. Lazebnik,et al.  Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[31]  H. Horvitz,et al.  Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein , 1995, Nature.

[32]  J. Rothman,et al.  dad‐1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates. , 1995, The EMBO journal.

[33]  Z. Oltvai,et al.  Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Seamus J. Martin,et al.  Protease activation during apoptosis: Death by a thousand cuts? , 1995, Cell.

[35]  M. Tewari,et al.  CrmA-inhibitable Cleavage of the 70-kDa Protein Component of the U1 Small Nuclear Ribonucleoprotein during Fas- and Tumor Necrosis Factor-induced Apoptosis (*) , 1995, The Journal of Biological Chemistry.

[36]  M. Tewari,et al.  The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis (*) , 1995, The Journal of Biological Chemistry.

[37]  Patrick R. Griffin,et al.  Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis , 1995, Nature.

[38]  E. Alnemri,et al.  Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. , 1995, Cancer research.

[39]  S. Molineaux,et al.  Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases (*) , 1995, The Journal of Biological Chemistry.

[40]  J. Mankovich,et al.  Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1β-converting Enzyme Family of Cysteine Proteases (*) , 1995, The Journal of Biological Chemistry.

[41]  Muneesh Tewari,et al.  Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase , 1995, Cell.

[42]  Arul M. Chinnaiyan,et al.  FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis , 1995, Cell.

[43]  J. Cleveland,et al.  Contenders in FasL/TNF death signaling , 1995, Cell.

[44]  D. Goeddel,et al.  The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation , 1995, Cell.

[45]  G. Salvesen,et al.  Granzyme B Is Inhibited by the Cowpox Virus Serpin Cytokine Response Modifier A(*) , 1995, The Journal of Biological Chemistry.

[46]  S. Nagata,et al.  Involvement of an ICE-like protease in Fas-mediated apoptosis , 1995, Nature.

[47]  W. Fiers,et al.  Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis , 1995, Nature.

[48]  M. Su,et al.  A novel human protease similar to the interleukin‐1 beta converting enzyme induces apoptosis in transfected cells. , 1995, The EMBO journal.

[49]  D. Marguet,et al.  Homology between reaper and the cell death domains of Fas and TNFR1 , 1995, Cell.

[50]  N. Neamati,et al.  Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei. , 1995, Journal of immunology.

[51]  J. Camonis,et al.  A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain (*) , 1995, The Journal of Biological Chemistry.

[52]  J. Trapani,et al.  Granzymes: exogenous proteinases that induce target cell apoptosis. , 1995, Immunology today.

[53]  M. Su,et al.  Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. , 1995, Science.

[54]  H. Steller Mechanisms and genes of cellular suicide , 1995, Science.

[55]  C. Thompson,et al.  Apoptosis in the pathogenesis and treatment of disease , 1995, Science.

[56]  E. Wagner,et al.  Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. , 1995, Genes & development.

[57]  M. Tewari,et al.  Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product (*) , 1995, The Journal of Biological Chemistry.

[58]  R. Kamen,et al.  Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock , 1995, Cell.

[59]  T. Crawford,et al.  The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy , 1995, Cell.

[60]  J. Camonis,et al.  Self-association of the Death Domains of the p55 Tumor Necrosis Factor (TNF) Receptor and Fas/APO1 Prompts Signaling for TNF and Fas/APO1 Effects (*) , 1995, The Journal of Biological Chemistry.

[61]  J. Martinou,et al.  Viral proteins E1B19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation , 1995, The Journal of cell biology.

[62]  E. Alnemri,et al.  CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. , 1994, The Journal of biological chemistry.

[63]  D. K. Miller,et al.  Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death. , 1994, The Journal of biological chemistry.

[64]  M. Clarke,et al.  The Bcl-2 family of proteins: regulators of cell death and survival. , 1994, Trends in cell biology.

[65]  M. S. Williams,et al.  Apoptotic cell death induced by intracellular proteolysis. , 1994, Journal of immunology.

[66]  J. M. Boyd,et al.  Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins , 1994, Cell.

[67]  K. Schulze-Osthoff,et al.  Cell nucleus and DNA fragmentation are not required for apoptosis , 1994, The Journal of cell biology.

[68]  E. White Function of the adenovirus E1B oncogene in infected and transformed cells , 1994 .

[69]  Y. Lazebnik,et al.  Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE , 1994, Nature.

[70]  L. Wang,et al.  Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death , 1994, Cell.

[71]  F. Cope,et al.  Apoptosis II: The Molecular Basis of Apoptosis in Disease , 1994 .

[72]  H. Horvitz,et al.  The ins and outs of programmed cell death during C. elegans development. , 1994, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[73]  R. J. Clem,et al.  Control of programmed cell death by the baculovirus genes p35 and iap , 1994, Molecular and cellular biology.

[74]  N. Copeland,et al.  Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. , 1994, Genes & development.

[75]  J. Rothman,et al.  Baculovirus p35 prevents developmentally programmed cell death and rescues a ced‐9 mutant in the nematode Caenorhabditis elegans. , 1994, The EMBO journal.

[76]  H. Steller,et al.  Genetic control of programmed cell death in Drosophila. , 1994, Science.

[77]  M. Raff,et al.  Programmed cell death and Bcl‐2 protection in the absence of a nucleus. , 1994, The EMBO journal.

[78]  Timothy J. Ley,et al.  Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells , 1994, Cell.

[79]  David L. Vaux,et al.  An evolutionary perspective on apoptosis , 1994, Cell.

[80]  H. Horvitz,et al.  C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2 , 1994, Cell.

[81]  M. Fishman,et al.  Prevention of vertebrate neuronal death by the crmA gene. , 1994, Science.

[82]  M. Peitsch,et al.  The apoptosis endonucleases: cleaning up after cell death? , 1994, Trends in cell biology.

[83]  John Calvin Reed Bcl-2 and the regulation of programmed cell death , 1994, The Journal of cell biology.

[84]  D. Bredesen,et al.  Expression of the Baculovirus p35 Gene Inhibits Mammalian Neural Cell Death , 1993, Journal of neurochemistry.

[85]  Shai Shaham,et al.  The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme , 1993, Cell.

[86]  Junying Yuan,et al.  Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3 , 1993, Cell.

[87]  S. Komiyama,et al.  Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells , 1993, Molecular and cellular biology.

[88]  M. Rowe,et al.  Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[89]  L. Tartaglia,et al.  A novel domain within the 55 kd TNF receptor signals cell death , 1993, Cell.

[90]  N. Davidson,et al.  Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. , 1993, Cancer research.

[91]  S. Korsmeyer,et al.  Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death , 1993, Cell.

[92]  S. Nagata,et al.  A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. , 1993, The Journal of biological chemistry.

[93]  R. Aebersold,et al.  Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions , 1992, The Journal of experimental medicine.

[94]  P. Möller,et al.  Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens. , 1992, Journal of immunology.

[95]  V. Dixit,et al.  The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. , 1992, The Journal of biological chemistry.

[96]  R. Black,et al.  Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme , 1992, Cell.

[97]  K. O. Elliston,et al.  A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes , 1992, Nature.

[98]  M. Hengartner,et al.  Caenorhabditis elegans gene ced-9 protects cells from programmed cell death , 1992, Nature.

[99]  M. Raff,et al.  Social controls on cell survival and cell death , 1992, Nature.

[100]  R. J. Clem,et al.  Prevention of apoptosis by a baculovirus gene during infection of insect cells. , 1991, Science.

[101]  Atsushi Hase,et al.  The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis , 1991, Cell.

[102]  C. Smith,et al.  A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. , 1990, Science.

[103]  H. Horvitz,et al.  The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. , 1990, Developmental biology.

[104]  H. Horvitz,et al.  Genetic control of programmed cell death in the nematode C. elegans , 1986, Cell.

[105]  A. Chinnaiyan,et al.  CD95 (APO-1/Fas)-associating signalling proteins. , 1996, Cell death and differentiation.

[106]  E. White,et al.  Life, death, and the pursuit of apoptosis. , 1996, Genes & development.

[107]  S. Nagata,et al.  Fas and Fas ligand: lpr and gld mutations. , 1995, Immunology today.

[108]  D. Goeddel,et al.  The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. , 1995, Cell.

[109]  G. Majno,et al.  Apoptosis, oncosis, and necrosis. An overview of cell death. , 1995, The American journal of pathology.

[110]  G. Evan,et al.  Apoptosis and the cell cycle. , 1995, Current opinion in cell biology.

[111]  B. Beutler,et al.  Tumor Necrosis Factor: The molecules and Their Emerging Role in Medicine , 1992 .

[112]  H. Horvitz,et al.  Mechanisms and functions of cell death. , 1991, Annual review of cell biology.