Endothelin-1 mediated glycosaminoglycan synthesizing gene expression involves NOX-dependent transactivation of the transforming growth factor-β receptor

[1]  P. Little,et al.  Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling , 2021, Molecules.

[2]  P. Little,et al.  Lysophosphatidic acid receptor 5 transactivation of TGFBR1 stimulates the mRNA expression of proteoglycan synthesizing genes XYLT1 and CHST3. , 2020, Biochimica et biophysica acta. Molecular cell research.

[3]  P. Little,et al.  Toll-like Receptor 4 Stimulates Gene Expression via Smad2 Linker Region Phosphorylation in Vascular Smooth Muscle Cells. , 2020, ACS pharmacology & translational science.

[4]  Wenhua Zheng,et al.  GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species , 2019, Vascular biology.

[5]  P. Little,et al.  Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation , 2019, Journal of Cell Communication and Signaling.

[6]  Wenhua Zheng,et al.  Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis , 2018, Pharmacology & therapeutics.

[7]  Wenhua Zheng,et al.  Flavopiridol Inhibits TGF-β-Stimulated Biglycan Synthesis by Blocking Linker Region Phosphorylation and Nuclear Translocation of Smad2 , 2018, The Journal of Pharmacology and Experimental Therapeutics.

[8]  Wenhua Zheng,et al.  RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells , 2017, PloS one.

[9]  M. Hollenberg,et al.  Insights into cellular signalling by G protein coupled receptor transactivation of cell surface protein kinase receptors , 2017, Journal of Cell Communication and Signaling.

[10]  P. Little,et al.  Endothelin‐1 (ET‐1) stimulates carboxy terminal Smad2 phosphorylation in vascular endothelial cells by a mechanism dependent on ET receptors and de novo protein synthesis , 2016, The Journal of pharmacy and pharmacology.

[11]  M. Hollenberg,et al.  Integrating the GPCR transactivation‐dependent and biased signalling paradigms in the context of PAR1 signalling , 2016, British journal of pharmacology.

[12]  Wenhua Zheng,et al.  The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle. , 2016, Cellular signalling.

[13]  R. Ammendola,et al.  Cell-Surface Receptors Transactivation Mediated by G Protein-Coupled Receptors , 2014, International journal of molecular sciences.

[14]  M. Febbraio,et al.  Thrombin-mediated Proteoglycan Synthesis Utilizes Both Protein-tyrosine Kinase and Serine/Threonine Kinase Receptor Transactivation in Vascular Smooth Muscle Cells* , 2013, The Journal of Biological Chemistry.

[15]  Wenhua Zheng,et al.  G protein coupled receptor transactivation: extending the paradigm to include serine/threonine kinase receptors. , 2012, The international journal of biochemistry & cell biology.

[16]  Dyah Samti Mayasari,et al.  Correlation of C4ST-1 and ChGn-2 expression with chondroitin sulfate chain elongation in atherosclerosis. , 2011, Biochemical and biophysical research communications.

[17]  H. Kitagawa,et al.  Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in co-operation with chondroitin N-acetylgalactosaminyltransferase-2. , 2011, The Biochemical journal.

[18]  P. Little,et al.  Endothelin-1 Stimulation of Proteoglycan Synthesis in Vascular Smooth Muscle is Mediated by Endothelin Receptor Transactivation of the Transforming Growth Factor-β Type I Receptor , 2010, Journal of cardiovascular pharmacology.

[19]  P. Little,et al.  PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL. , 2010, Endocrinology.

[20]  P. Little,et al.  Thrombin Stimulation of Proteoglycan Synthesis in Vascular Smooth Muscle Is Mediated by Protease-activated Receptor-1 Transactivation of the Transforming Growth Factor β Type I Receptor* , 2010, The Journal of Biological Chemistry.

[21]  J. D. de Haan,et al.  Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo , 2009, Journal of cellular and molecular medicine.

[22]  P. Little,et al.  Endothelin-1 activates ETA receptors on human vascular smooth muscle cells to yield proteoglycans with increased binding to LDL. , 2009, Atherosclerosis.

[23]  J. Pernow,et al.  The importance of endothelin-1 for vascular dysfunction in cardiovascular disease. , 2007, Cardiovascular research.

[24]  H. Kitagawa,et al.  Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor. , 2007, The Biochemical journal.

[25]  P. Little,et al.  Vascular wall proteoglycan synthesis and structure as a target for the prevention of atherosclerosis , 2007, Vascular health and risk management.

[26]  Yen-Ling Chen,et al.  Reactive Oxygen Species Generation Is Involved in Epidermal Growth Factor Receptor Transactivation through the Transient Oxidization of Src Homology 2-Containing Tyrosine Phosphatase in Endothelin-1 Signaling Pathway in Rat Cardiac Fibroblasts , 2006, Molecular Pharmacology.

[27]  J. Egido,et al.  Endothelin-1, via ETA Receptor and Independently of Transforming Growth Factor-&bgr;, Increases the Connective Tissue Growth Factor in Vascular Smooth Muscle Cells , 2005, Circulation research.

[28]  L. Wold,et al.  Endothelin‐1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ETB receptor, NADPH oxidase and caveolin‐1 , 2005, British journal of pharmacology.

[29]  Stephanie W. Watts,et al.  Endothelin-1 Increases Vascular Superoxide via EndothelinA–NADPH Oxidase Pathway in Low-Renin Hypertension , 2003, Circulation.

[30]  P. Vijayagopal,et al.  Angiotensin II stimulates synthesis of vascular smooth muscle cell proteoglycans with enhanced low density lipoprotein binding properties. , 2002, Atherosclerosis.

[31]  A. Ullrich,et al.  Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors , 1996, Nature.

[32]  M. Barras,et al.  ROS directly activates transforming growth factor β type 1 receptor signalling in human vascular smooth muscle cells. , 2019, Biochimica et biophysica acta. General subjects.

[33]  Wenhua Zheng,et al.  Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes. , 2019, Cellular signalling.

[34]  M. Hollenberg,et al.  Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes. , 2016, Cellular signalling.

[35]  Wenhua Zheng,et al.  The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier , 2014, Cellular and Molecular Life Sciences.

[36]  M. Zerfaoui,et al.  Microvessel vascular smooth muscle cells contribute to collagen type I deposition through ERK 1 / 2 MAP kinase , v 3-integrin , and TGF-1 in response to ANG II and high glucose , 2008 .