Ventricular Assist Devices as a Bridge to Transplant or Recovery

Ventricular assist devices have emerged as the standard of care in treating end-stage heart failure. Their success in bridging patients to transplantation is well documented. The data supporting their ability to bridge patients to recovery is sparser. However, as technology continues to advance, these devices will offer a high quality of life both in and out of the hospital setting, making them options for a broader spectrum of heart failure patients.

[1]  T. Akutsu,et al.  Cardiac disuse atrophy during LVAD pumping. , 1988, ASAIO transactions.

[2]  R. Adamson,et al.  Acute fulminant myocarditis: long-term follow-up after circulatory support with left ventricular assist device. , 1991, American heart journal.

[3]  J. Kirklin,et al.  Case report: circulatory support for seventy days with resolution of acute heart failure. , 1991, The Journal of thoracic and cardiovascular surgery.

[4]  N. Kouchoukos,et al.  Postcardiotomy mechanical circulatory support in the elderly. , 1991, The Annals of thoracic surgery.

[5]  T. Gonwa,et al.  Reversal of acute fulminant lymphocytic myocarditis with combined technology of OKT3 monoclonal antibody and mechanical circulatory support. , 1992, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[6]  B. Griffith,et al.  Quantitation of right ventricular shape changes after left ventricular assist device implantation. , 1992, ASAIO journal.

[7]  C. Miller,et al.  Ventricular assist devices for postcardiotomy cardiogenic shock. A combined registry experience. , 1992, The Journal of thoracic and cardiovascular surgery.

[8]  P. Myles,et al.  Muscling in on salbutamol , 1992, The Lancet.

[9]  H. Perry Clenbuterol: a medal in tablet form? , 1993, British journal of sports medicine.

[10]  K. Broadley,et al.  Muscling in on salbutamol , 1993, The Lancet.

[11]  M. Bristow,et al.  Economic impact of heart failure in the United States: time for a different approach. , 1994, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[12]  J. Kirklin,et al.  Influence of longer term left ventricular assist device support on valvular regurgitation. , 1994, ASAIO journal.

[13]  H Harasaki,et al.  Structural and left ventricular histologic changes after implantable LVAD insertion. , 1995, The Annals of thoracic surgery.

[14]  M. Oz,et al.  Preperitoneal Placement of Ventricular Assist Devices: An Illustrated Stepwise Approach , 1995, Journal of cardiac surgery.

[15]  W S Pierce,et al.  Combined Registry for the Clinical Use of Mechanical Ventricular Assist Pumps and the Total Artificial Heart in conjunction with heart transplantation: sixth official report--1994. , 1995, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[16]  M. Oz,et al.  Prosthetic abdominal fascial closure after ventricular assist device insertion. , 1995, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[17]  M C Oz,et al.  Reversal of chronic ventricular dilation in patients with end-stage cardiomyopathy by prolonged mechanical unloading. , 1995, Circulation.

[18]  M C Oz,et al.  Low thromboembolic risk without anticoagulation using advanced-design left ventricular assist devices. , 1996, The Annals of thoracic surgery.

[19]  N. Smedira,et al.  Age related outcome after implantable left ventricular assist system support. , 1996, ASAIO journal.

[20]  R. Körfer,et al.  Management of acute fulminant myocarditis using circulatory support systems. , 1996, Artificial organs.

[21]  R. Mentzer,et al.  Myofibrillar calcium sensitivity of isometric tension is increased in human dilated cardiomyopathies: role of altered beta-adrenergically mediated protein phosphorylation. , 1996, The Journal of clinical investigation.

[22]  Y. Taenaka,et al.  Influence of prolonged ventricular assistance on myocardial histopathology in intact heart. , 1996, The Annals of thoracic surgery.

[23]  M. Oz,et al.  Implantable left ventricular assist devices provide an excellent outpatient bridge to transplantation and recovery. , 1997, Journal of the American College of Cardiology.

[24]  P. Vandervoort,et al.  Left ventricular diastolic filling with an implantable ventricular assist device: beat to beat variability with overall improvement. , 1997, Journal of the American College of Cardiology.

[25]  S. Houser,et al.  Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure. , 1998, Circulation.

[26]  M C Oz,et al.  Implantable left ventricular assist devices. , 1998, The New England journal of medicine.

[27]  T. Myers,et al.  The HeartMate left ventricular assist system. Overview and 12-year experience. , 1998, Texas Heart Institute journal.

[28]  M Flannery,et al.  Low incidence of myocardial recovery after left ventricular assist device implantation in patients with chronic heart failure. , 1998, Circulation.

[29]  J. Copeland,et al.  The CardioWest total artificial heart bridge to transplantation: 1993 to 1996 national trial. , 1998, The Annals of thoracic surgery.

[30]  K. Boheler,et al.  Clenbuterol induces cardiac hypertrophy with normal functional, morphological and molecular features. , 1998, Cardiovascular research.

[31]  S. Houser,et al.  Regression of cellular hypertrophy after left ventricular assist device support. , 1998, Circulation.

[32]  L. Soloff Atrophy of myocardium and its myocytes by left ventricular assist device. , 1999, Circulation.

[33]  Poirier Vl,et al.  Worldwide Experience With the TCI HeartMate® System: Issues and Future Perspective , 1999, The Thoracic and cardiovascular surgeon.

[34]  G. Noon,et al.  Decreased expression of tumor necrosis factor-alpha in failing human myocardium after mechanical circulatory support : A potential mechanism for cardiac recovery. , 1999, Circulation.

[35]  D. N. Helman,et al.  Left ventricular assist device bridge-to-transplant network improves survival after failed cardiotomy. , 1999, The Annals of thoracic surgery.

[36]  S. Murali,et al.  Mechanical circulatory support with the Novacor LVAS: world-wide clinical results. , 1999, The Thoracic and cardiovascular surgeon.

[37]  J. Copeland,et al.  Arizona experience with CardioWest Total Artificial Heart bridge to transplantation. , 1999, The Annals of thoracic surgery.

[38]  U Schütt,et al.  Bridging to Cardiac Transplantation With the Thoratec Ventricular Assist Device , 1999, The Thoracic and cardiovascular surgeon.

[39]  R Hetzer,et al.  Cardiac recovery in dilated cardiomyopathy by unloading with a left ventricular assist device. , 1999, The Annals of thoracic surgery.

[40]  V. Poirier Worldwide experience with the TCI HeartMate system: issues and future perspective. , 1999, The Thoracic and cardiovascular surgeon.

[41]  S. Bolling,et al.  Extracorporeal life support to left ventricular assist device bridge to heart transplant: A strategy to optimize survival and resource utilization. , 1999, Circulation.

[42]  D. N. Helman,et al.  Recurrent remodeling after ventricular assistance: is long-term myocardial recovery attainable? , 2000, The Annals of thoracic surgery.

[43]  D. N. Helman,et al.  Implantable left ventricular assist devices can successfully bridge adolescent patients to transplant. , 2000, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[44]  M. Oz,et al.  Outpatient left ventricular assist device support: a safe and economical therapeutic option for heart failure. , 2000, Progress in cardiovascular diseases.

[45]  G. Tenderich,et al.  Novacor left ventricular assist system versus Heartmate vented electric left ventricular assist system as a long-term mechanical circulatory support device in bridging patients: a prospective study. , 2000, The Journal of thoracic and cardiovascular surgery.

[46]  J. Copeland Mechanical assist device; my choice: the CardioWest total artificial heart. , 2000, Transplantation proceedings.

[47]  D. Farrar,et al.  The thoratec ventricular assist device: a paracorporeal pump for treating acute and chronic heart failure. , 2000, Seminars in thoracic and cardiovascular surgery.

[48]  G. Breithardt,et al.  Selection and management of ventricular assist device patients: the Muenster experience. , 2000, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[49]  R. Hetzer,et al.  Midterm follow-up of patients who underwent removal of a left ventricular assist device after cardiac recovery from end-stage dilated cardiomyopathy. , 2000, The Journal of thoracic and cardiovascular surgery.

[50]  D. Burkhoff,et al.  Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure , 2000, Circulation.

[51]  J D Thomas,et al.  Clinical utility of echocardiography in the management of implantable ventricular assist devices. , 2000, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[52]  Copeland Jg Mechanical assist device; my choice: the CardioWest total artificial heart. , 2000 .

[53]  F. Hoy,et al.  Bridge to recovery for postcardiotomy failure: is there still a role for centrifugal pumps? , 2000, The Annals of thoracic surgery.

[54]  M. Oz,et al.  Multicenter clinical evaluation of the HeartMate vented electric left ventricular assist system in patients awaiting heart transplantation. , 2001, The Journal of thoracic and cardiovascular surgery.

[55]  K. Butler,et al.  HeartMate left ventricular assist devices: a multigeneration of implanted blood pumps. , 2001, Artificial organs.

[56]  G P Noon,et al.  Clinical experience with the MicroMed DeBakey ventricular assist device. , 2001, The Annals of thoracic surgery.

[57]  J F Antaki,et al.  HeartMate II left ventricular assist system: from concept to first clinical use. , 2001, The Annals of thoracic surgery.

[58]  M. Yacoub A novel strategy to maximize the efficacy of left ventricular assist devices as a bridge to recovery. , 2001, European heart journal.

[59]  D Morley,et al.  Clinical experience with nine patients supported by the continuous flow Debakey VAD. , 2001, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[60]  R K Jarvik,et al.  Research and development of an implantable, axial-flow left ventricular assist device: the Jarvik 2000 Heart. , 2001, The Annals of thoracic surgery.

[61]  S. Boyce,et al.  An anatomically compatible, wearless, reliable, and nonthrombogenic centrifugal blood pump. , 2001, The Annals of thoracic surgery.

[62]  M. Oz,et al.  Multicenter clinical evaluation of the heartmate; vented electric left ventricular assist system in patients awaiting heart transplantation. , 2001, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[63]  D J Burke,et al.  The Heartmate II: design and development of a fully sealed axial flow left ventricular assist system. , 2001, Artificial organs.

[64]  D. Mann,et al.  Differential Regulation of Mitogen-Activated Protein Kinases in the Failing Human Heart in Response to Mechanical Unloading , 2001, Circulation.

[65]  D. Burkhoff,et al.  Time course of reverse remodeling of the left ventricle during support with a left ventricular assist device. , 2001, The Journal of thoracic and cardiovascular surgery.

[66]  P M Portner,et al.  The totally implantable novacor left ventricular assist system. , 2001, The Annals of thoracic surgery.

[67]  N. Smedira,et al.  Mechanical Unloading Restores &bgr;-Adrenergic Responsiveness and Reverses Receptor Downregulation in the Failing Human Heart , 2001, Circulation.

[68]  John P. Gaughan,et al.  Electrophysiological Alterations After Mechanical Circulatory Support in Patients With Advanced Cardiac Failure , 2001, Circulation.

[69]  M C Oz,et al.  Long-term use of a left ventricular assist device for end-stage heart failure. , 2001, The New England journal of medicine.

[70]  A. Pavie,et al.  Mechanical Circulatory Support for Advanced Heart Failure , 2001 .

[71]  G P Noon,et al.  Transcranial Detection of Microembolic Signals in Patients with a Novel Nonpulsatile Implantable LVAD , 2001, ASAIO journal.

[72]  George P. Noon,et al.  Inflammatory Response after Implantation of a Left Ventricular Assist Device: Comparison between the Axial Flow MicroMed DeBakey VAD and the Pulsatile Novacor Device , 2001, ASAIO journal.

[73]  G. Noon,et al.  Regression of fibrosis and hypertrophy in failing myocardium following mechanical circulatory support. , 2001, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[74]  E Wolner,et al.  Transitory immunologic response after implantation of the DeBakey VAD continuous-axial-flow pump. , 2002, The Journal of thoracic and cardiovascular surgery.

[75]  Robert L Kormos,et al.  Long-term follow-up of Thoratec ventricular assist device bridge-to-recovery patients successfully removed from support after recovery of ventricular function. , 2002, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[76]  L. Miller,et al.  Cardiac recovery during 30 days of support with a left ventricular assist device. Preliminary results from the LVAD working group , 2003 .

[77]  T. Myers,et al.  Dobutamine stress echocardiography predicts myocardial improvement in patients supported by left ventricular assist devices (LVADs): hemodynamic and histologic evidence of improvement before LVAD explantation. , 2003, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[78]  M. Oz,et al.  Assessment of myocardial recovery in a patient with acute myocarditis supported with a left ventricular assist device: a case report. , 2003, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[79]  J. Shinn Implantable Left Ventricular Assist Devices , 2005, The Journal of cardiovascular nursing.