As soon as telemedicine aims at supporting the prevention of ischemic events (e.g., stroke and myocardial infarction), the mere monitoring of vital parameters is not sufficient. Instead, the patients should be supported in their efforts to actively reduce their individual risk factors and to achieve and maintain a healthier lifestyle. The Luxembourg-based CAPSYS project (Computer-Aided Prevention System) aims at combining the advantages of telephone coaching with those of home telemonitoring and with methods of computer-aided decision support in direct contact with the patients. The suitability and user acceptance of the system is currently being evaluated in a first pilot study.