Osteosarcopenic obesity in women : impact , prevalence , and management challenges

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[1]  T. G. Barbosa-Silva,et al.  Sarcopenia as a mortality predictor in community-dwelling older adults: a comparison of the diagnostic criteria of the European Working Group on Sarcopenia in Older People , 2019, European Journal of Clinical Nutrition.

[2]  J. Ilich,et al.  Macronutrient Intake and Distribution in the Etiology, Prevention and Treatment of Osteosarcopenic Obesity. , 2017, Current aging science.

[3]  O. Kelly,et al.  Can Unconventional Exercise be Helpful in the Treatment, Management and Prevention of Osteosarcopenic Obesity? , 2017, Current aging science.

[4]  J. Ilich,et al.  Micronutrient Intake in the Etiology, Prevention and Treatment of Osteosarcopenic Obesity. , 2016, Current aging science.

[5]  J. Ilich,et al.  Osteosarcopenic Obesity Syndrome: What Is It and How Can It Be Identified and Diagnosed? , 2016, Current gerontology and geriatrics research.

[6]  G. Chrousos,et al.  Healthy overweight/obese youth: early osteosarcopenic obesity features , 2016, European journal of clinical investigation.

[7]  J. Ilich,et al.  Possible Nutritional Etiology of Osteosarcopenic Obesity Syndrome , 2016, The FASEB Journal.

[8]  H. Goossens,et al.  12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis , 2016, Mediators of inflammation.

[9]  L. Pereira,et al.  Prevalence of sarcopenia among the elderly: findings from broad cross-sectional studies in a range of countries , 2015 .

[10]  J. Ilich,et al.  The Microbiome and Osteosarcopenic Obesity in Older Individuals in Long-Term Care Facilities , 2015, Current Osteoporosis Reports.

[11]  D. Volkert,et al.  Sarcopenic obesity and complex interventions with nutrition and exercise in community-dwelling older persons – a narrative review , 2015, Clinical interventions in aging.

[12]  C. Nowson,et al.  Protein Requirements and Recommendations for Older People: A Review , 2015, Nutrients.

[13]  P. Ebeling,et al.  Fall and Fracture Risk in Sarcopenia and Dynapenia With and Without Obesity: the Role of Lifestyle Interventions , 2015, Current Osteoporosis Reports.

[14]  D. McGee,et al.  Osteosarcopenic obesity is associated with reduced handgrip strength, walking abilities, and balance in postmenopausal women , 2015, Osteoporosis International.

[15]  R. Laqua,et al.  Positive Association Between Adipose Tissue and Bone Stiffness , 2015, Calcified Tissue International.

[16]  M. Picklo,et al.  Involuntary Wheel Running Improves but Does Not Fully Reverse the Deterioration of Bone Structure of Obese Rats Despite Decreasing Adiposity , 2015, Calcified Tissue International.

[17]  J. Ilich,et al.  Adipokines as Mediators of Bone Density in Overweight/Obese Postmenopausal Women After 6‐Month Weight Loss Program , 2015 .

[18]  A. Martínez-Amat,et al.  Osteosarcopenic obesity and fall prevention strategies. , 2015, Maturitas.

[19]  Z. Bar‐Shavit,et al.  Regulation of Osteoclastogenesis by Integrated Signals From Toll‐Like Receptors , 2014, Journal of cellular biochemistry.

[20]  Sunita Ghosh,et al.  New Insight into Fat, Muscle and Bone Relationship in Women: Determining the Threshold at Which Body Fat Assumes Negative Relationship with Bone Mineral Density , 2014, International journal of preventive medicine.

[21]  S. Anker,et al.  Prevalence, incidence, and clinical impact of sarcopenia: facts, numbers, and epidemiology—update 2014 , 2014, Journal of cachexia, sarcopenia and muscle.

[22]  Anna Maria Ferriero,et al.  Economic impact of adult obesity on health systems: a systematic review. , 2014, European journal of public health.

[23]  J. Ilich,et al.  Low-grade chronic inflammation perpetuated by modern diet as a promoter of obesity and osteoporosis , 2014, Arhiv za higijenu rada i toksikologiju.

[24]  L. Panton,et al.  Interrelationship among muscle, fat, and bone: Connecting the dots on cellular, hormonal, and whole body levels , 2014, Ageing Research Reviews.

[25]  Stephen S. Lim,et al.  The global burden attributable to low bone mineral density , 2014, Annals of the rheumatic diseases.

[26]  Stuart M Phillips,et al.  Alterations in human muscle protein metabolism with aging: Protein and exercise as countermeasures to offset sarcopenia , 2014, BioFactors.

[27]  L. Panton,et al.  Physical Performance in Relation to Body Composition and Bone Mineral Density in Healthy, Overweight, and Obese Postmenopausal Women , 2014, Journal of geriatric physical therapy.

[28]  P. Cederna,et al.  Reconciling the effects of inflammatory cytokines on mesenchymal cell osteogenic differentiation. , 2013, The Journal of surgical research.

[29]  K. Flegal,et al.  Prevalence of obesity among adults: United States, 2011-2012. , 2013, NCHS data brief.

[30]  J. Ilich,et al.  Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis. , 2013, Nutrition research.

[31]  B. Pedersen.  Muscle as a secretory organ. , 2013, Comprehensive Physiology.

[32]  Stuart M Phillips,et al.  Interactions between exercise and nutrition to prevent muscle waste during ageing. , 2013, British journal of clinical pharmacology.

[33]  Kyungwon Oh,et al.  Body Fat Percentile Curves for Korean Children and Adolescents: A Data from the Korea National Health and Nutrition Examination Survey 2009-2010 , 2013, Journal of Korean medical science.

[34]  P. Menezes,et al.  Discriminating sarcopenia in community-dwelling older women with high frequency of overweight/obesity: the São Paulo Ageing & Health Study (SPAH) , 2013, Osteoporosis International.

[35]  M. R. Franco,et al.  Exercise interventions for preventing falls in older people living in the community , 2013, British Journal of Sports Medicine.

[36]  S. Shapses,et al.  Bone metabolism in obesity and weight loss. , 2012, Annual review of nutrition.

[37]  Frank A. Liporace,et al.  Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet , 2012, The open orthopaedics journal.

[38]  W. Kemmler,et al.  Alternative Exercise Technologies to Fight against Sarcopenia at Old Age: A Series of Studies and Review , 2012, Journal of aging research.

[39]  Katherine M Flegal,et al.  Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. , 2012, JAMA.

[40]  Christopher J. Hanrahan,et al.  MRI of spinal bone marrow: part 2, T1-weighted imaging-based differential diagnosis. , 2011, AJR. American journal of roentgenology.

[41]  Carrie D. Patnode,et al.  Screening for and Management of Obesity and Overweight in Adults , 2011 .

[42]  J. Reilly,et al.  Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review , 2011, International Journal of Obesity.

[43]  B. Franklin,et al.  American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. , 2011, Medicine and science in sports and exercise.

[44]  R. Wolfe,et al.  The anabolic response to resistance exercise and a protein-rich meal is not diminished by age , 2011, The journal of nutrition, health & aging.

[45]  H. Chung,et al.  Molecular Inflammation as an Underlying Mechanism of the Aging Process and Age-related Diseases , 2011, Journal of dental research.

[46]  Y. Rolland,et al.  Cachexia versus sarcopenia , 2011, Current opinion in clinical nutrition and metabolic care.

[47]  J. Lattimer,et al.  Effects of Dietary Fiber and Its Components on Metabolic Health , 2010, Nutrients.

[48]  Stuart M Phillips,et al.  Resistance exercise and appropriate nutrition to counteract muscle wasting and promote muscle hypertrophy , 2010, Current opinion in clinical nutrition and metabolic care.

[49]  C. Meyerhoefer,et al.  The Medical Care Costs of Obesity: an Instrumental Variables Approach , 2010, Journal of health economics.

[50]  Yong Liu,et al.  Assessment of bone marrow changes in postmenopausal women with varying bone densities: magnetic resonance spectroscopy and diffusion magnetic resonance imaging. , 2010, Chinese medical journal.

[51]  Long Yu,et al.  Oxidative Stress, Molecular Inflammation and Sarcopenia , 2010, International journal of molecular sciences.

[52]  T. Manini,et al.  Sarcopenia: Clinical evaluation, biological markers and other evaluation tools , 2009, The journal of nutrition, health & aging.

[53]  Stuart M Phillips,et al.  Resistance exercise and nutrition to counteract muscle wasting. , 2009, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[54]  W. Evans,et al.  Influence of exercise intensity on abdominal fat and adiponectin in elderly adults. , 2009, Metabolic syndrome and related disorders.

[55]  R. Brownbill,et al.  Habitual and Low-Impact Activities are Associated with Better Bone Outcomes and Lower Body Fat in Older Women , 2008, Calcified Tissue International.

[56]  J. Summers.  The Office of Dietary Supplements , 2008 .

[57]  J. Gimble,et al.  Playing with bone and fat , 2006, Journal of cellular biochemistry.

[58]  M. Laposata,et al.  Effects of physiological leptin administration on markers of inflammation, platelet activation, and platelet aggregation during caloric deprivation. , 2005, The Journal of clinical endocrinology and metabolism.

[59]  M. Zemel,et al.  Effects of calcium and dairy on body composition and weight loss in African-American adults. , 2005, Obesity research.

[60]  K. Wellen,et al.  Inflammation, stress, and diabetes. , 2005, The Journal of clinical investigation.

[61]  John J. Shin,et al.  Differential effect of obesity on bone mineral density in White, Hispanic and African American women: a cross sectional study , 2005, Nutrition & metabolism.

[62]  Rhonda A. Brownbill,et al.  Measuring body composition in overweight individuals by dual energy x-ray absorptiometry , 2005, BMC Medical Imaging.

[63]  R. Ross,et al.  Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. , 2004, American journal of epidemiology.

[64]  J. Jakicic.  Exercise in the treatment of obesity. , 2003, Endocrinology and metabolism clinics of North America.

[65]  P. J. Bowman,et al.  Intentional and Unintentional Weight Loss Increase Bone Loss and Hip Fracture Risk in Older Women , 2003, Journal of the American Geriatrics Society.

[66]  Y. Boirie,et al.  Daily protein intakes and eating patterns in young and elderly French , 2003, British Journal of Nutrition.

[67]  S. Rubin,et al.  Sarcopenia: Alternative Definitions and Associations with Lower Extremity Function , 2003, Journal of the American Geriatrics Society.

[68]  O. Johnell,et al.  Ten Year Probabilities of Osteoporotic Fractures According to BMD and Diagnostic Thresholds , 2001, Osteoporosis International.

[69]  J. Morley,et al.  Anorexia, sarcopenia, and aging. , 2001, Nutrition.

[70]  R. Wolfe,et al.  The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[71]  G E Dallal,et al.  Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity, and health. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[72]  Susan R. Johnson,et al.  Osteoporosis prevention, diagnosis, and therapy. , 2001, JAMA.

[73]  Z. Tran,et al.  Resistance Training and Bone Mineral Density in Women: A Meta-Analysis of Controlled Trials , 2001, American journal of physical medicine & rehabilitation.

[74]  F. Quaade,et al.  Bone Mineral Changes in Obese Women During a Moderate Weight Loss With and Without Calcium Supplementation , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[75]  S. Gordon,et al.  Waging war on modern chronic diseases: primary prevention through exercise biology , 2000, Journal of applied physiology.

[76]  S. Kihara,et al.  Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-&kgr;B Signaling Through a cAMP-Dependent Pathway , 2000, Circulation.

[77]  W. Applegate,et al.  Effect of Voluntary Weight Loss on Bone Mineral Density in Older Overweight Women , 2000, Journal of the American Geriatrics Society.

[78]  T. Douchi,et al.  Difference in the effect of adiposity on bone density between pre- and postmenopausal women. , 2000, Maturitas.

[79]  G A Colditz,et al.  Economic costs of obesity and inactivity. , 1999, Medicine and science in sports and exercise.

[80]  R. Baumgartner,et al.  Predictors of skeletal muscle mass in elderly men and women , 1999, Mechanisms of Ageing and Development.

[81]  I. Rosenberg,et al.  Sarcopenia: origins and clinical relevance. , 1997, The Journal of nutrition.

[82]  J. Wark,et al.  Bone loss accompanying diet-induced or exercise-induced weight loss: a randomised controlled study. , 1996, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[83]  M. C. Crim,et al.  Increased protein requirements in elderly people: new data and retrospective reassessments. , 1994, The American journal of clinical nutrition.

[84]  R. Dodds,et al.  Expression of mRNA for IL1 beta, IL6 and TGF beta 1 in developing human bone and cartilage. , 1994, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[85]  P. Croucher,et al.  Effect of diet-induced weight loss on total body bone mass. , 1991, Clinical science.

[86]  J. Aloia,et al.  Prevention of involutional bone loss by exercise. , 1978, Annals of internal medicine.

[87]  Pegah Jafarinasabian.  Analyzing Bone, Muscle and Adipose Tissue Biomarkers to Identify Osteosarcopenic Obesity Syndrome in Older Women , 2017 .

[88]  Julia E. Inglis.  Identifying Osteosarcopenic Obesity in a Group of Older Women , 2017 .

[89]  K. Zhu,et al.  Discordance between fat mass index and body mass index is associated with reduced bone mineral density in women but not in men: the Busselton Healthy Ageing Study , 2016, Osteoporosis International.

[90]  T. Hosoi,et al.  [Falls and fractures]. , 2013, Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.

[91]  S. Perna,et al.  A path model of sarcopenia on bone mass loss in elderly subjects , 2013, The journal of nutrition, health & aging.

[92]  L. Doyle,et al.  The effect of a low-carbohydrate diet on biomarkers of bone health in pre- and post-menopausal females: a randomized control crossover trial , 2011, Proceedings of the Nutrition Society.

[93]  L. Pray,et al.  Providing healthy and safe foods as we age: Workshop summary. , 2010 .

[94]  K. E. Higgins,et al.  Physical activity guidelines for older adults. , 2010, American family physician.

[95]  J. Baeyens,et al.  European working group on sarcopenia in older people. Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people , 2010 .

[96]  Sarah E Lamb,et al.  Interventions for preventing falls in older people living in the community. , 2009, The Cochrane database of systematic reviews.

[97]  T. Travison,et al.  The relationship between body composition and bone mineral content: threshold effects in a racially and ethnically diverse group of men , 2007, Osteoporosis International.

[98]  Calcium Dietary Supplement Fact Sheet , 2007 .

[99]  D. Panagiotakos,et al.  Diet, exercise and the metabolic syndrome. , 2006, The review of diabetic studies : RDS.

[100]  L. Lanyon.  Functional strain as a determinant for bone remodeling , 2006, Calcified Tissue International.

[101]  Mary L Bouxsein,et al.  Mechanisms of Disease: is osteoporosis the obesity of bone? , 2006, Nature Clinical Practice Rheumatology.

[102]  W. Kohrt,et al.  American College of Sports Medicine Position Stand: physical activity and bone health. , 2004, Medicine and science in sports and exercise.

[103]  C. Ritchie,et al.  Sarcopenia, weight loss, and nutritional frailty in the elderly. , 2002, Annual review of nutrition.

[104]  H. Kemper,et al.  The Effect of Exercise Training Programs on Bone Mass: A Meta-analysis of Published Controlled Trials in Pre- and Postmenopausal Women , 1999, Osteoporosis International.