论文信息 - A CASE OF GRANULOCYTE-COLONY STIMULATING FACTOR PRODUCING METASTATIC BREAST CANCER

A CASE OF GRANULOCYTE-COLONY STIMULATING FACTOR PRODUCING METASTATIC BREAST CANCER

症例は63歳，女性．左乳癌（T2N0M0 stageIIA）のため術前化学療法施行したが，Progressive disease(PD)となり2007年7月左乳房切除術施行した．病理診断はT2N0M0，StageIIA，Squamous cell carcinoma，spindle cell variant，ER－，PgR－，HER2－．術後，weekly TXL，CDDP/TS-1，CDDP/TXTの化学療法を施行したが，2009年2月骨，頭皮，甲状腺，肺，両側腎に再発した．2009年3月24日入院時著明な白血球増多（31,200/μl），BT 36.5℃，CRP 5.72mg/dl，腫瘍マーカーCEA 3.4ng/ml，CA15-3 14U/ml，BCA225 34U/ml，NCC-ST-439 2.3U/ml，ICTP 8.9ng/mlを認めた．入院後末梢血中白血球は102,200/μlに上昇した．血清G-CSF 502pg/ml（正常値;8pg/ml以下）と高値を認めた．G-CSF産生腫瘍を疑い，原発巣のG-CSF免疫組織染色を行ったところ腫瘍細胞が染色されたことより，G-CSF産生乳癌と診断した．

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