Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers

[1]  R. Satija,et al.  Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression , 2019, Genome Biology.

[2]  Atul J. Butte,et al.  Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage , 2018, Nature Immunology.

[3]  Christoph Hafemeister,et al.  Comprehensive integration of single cell data , 2018, bioRxiv.

[4]  Vinicius S. Chagas,et al.  Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer , 2018, Cell.

[5]  Cyriac Kandoth,et al.  Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer , 2018, Cell.

[6]  M. Höglund,et al.  A validation and extended description of the Lund taxonomy for urothelial carcinoma using the TCGA cohort , 2018, Scientific Reports.

[7]  B. Bernstein,et al.  Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM , 2017, Clinical Cancer Research.

[8]  T. Ørntoft,et al.  Comprehensive multiregional analysis of molecular heterogeneity in bladder cancer , 2017, Scientific Reports.

[9]  M. Rubin,et al.  Transdifferentiation as a Mechanism of Treatment Resistance in a Mouse Model of Castration-Resistant Prostate Cancer. , 2017, Cancer discovery.

[10]  W. Oh,et al.  Strategies to avoid treatment-induced lineage crisis in advanced prostate cancer , 2017, Nature Reviews Clinical Oncology.

[11]  Hai Huang,et al.  Epithelial-mesenchymal transition induced by GRO-α-CXCR2 promotes bladder cancer recurrence after intravesical chemotherapy , 2017, Oncotarget.

[12]  M. Höglund,et al.  Molecular classification of urothelial carcinoma: global mRNA classification versus tumour‐cell phenotype classification , 2017, The Journal of pathology.

[13]  L. Zhou,et al.  Exploring the FGFR3-related oncogenic mechanism in bladder cancer using bioinformatics strategy , 2017, World Journal of Surgical Oncology.

[14]  M. Rubin,et al.  SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer , 2017, Science.

[15]  X. Fu,et al.  Grhl2 reduces invasion and migration through inhibition of TGFβ-induced EMT in gastric cancer , 2017, Oncogenesis.

[16]  Davide Prandi,et al.  Clonal evolution of chemotherapy-resistant urothelial carcinoma , 2016, Nature Genetics.

[17]  C. Dinney,et al.  Intrinsic subtypes and bladder cancer metastasis , 2016, Asian journal of urology.

[18]  Davis J. McCarthy,et al.  A step-by-step workflow for low-level analysis of single-cell RNA-seq data with Bioconductor , 2016, F1000Research.

[19]  Aaron T. L. Lun,et al.  Scater: pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R , 2017, Bioinform..

[20]  M. Höglund,et al.  Biological determinants of bladder cancer gene expression subtypes , 2015, Scientific Reports.

[21]  E. Gallardo,et al.  Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer , 2014, Molecular Cancer Therapeutics.

[22]  K. Baggerly,et al.  Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy. , 2014, Cancer cell.

[23]  Dong Wang,et al.  Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts , 2013, Stem cell reports.

[24]  Yan Geng,et al.  p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia , 2013, Proceedings of the National Academy of Sciences.

[25]  L. Tran,et al.  Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells. , 2012, Cancer research.

[26]  Jens-Peter Volkmer,et al.  Three differentiation states risk-stratify bladder cancer into distinct subtypes , 2012, Proceedings of the National Academy of Sciences.

[27]  Wun-Jae Kim,et al.  Identification of Gene Expression Signature Modulated by Nicotinamide in a Mouse Bladder Cancer Model , 2011, PloS one.

[28]  Kejun Zhang,et al.  Expression of transcription factors snail, slug, and twist in human bladder carcinoma , 2010, Journal of experimental & clinical cancer research : CR.

[29]  Jiaoti Huang,et al.  Identification of a Cell of Origin for Human Prostate Cancer , 2010, Science.

[30]  S. Memarzadeh,et al.  Basal epithelial stem cells are efficient targets for prostate cancer initiation , 2010, Proceedings of the National Academy of Sciences.

[31]  O. Witte,et al.  Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. , 2009, Cancer research.

[32]  Howard Y. Chang,et al.  Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells , 2009, Proceedings of the National Academy of Sciences.

[33]  J. Crawford.  The origins of bladder cancer , 2008, Laboratory Investigation.

[34]  E. Thompson,et al.  Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2. , 2006, Cancer research.

[35]  I. Tannock,et al.  Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. , 2004, The New England journal of medicine.