Phosphorylation of Serine 18 Regulates Distinct p53 Functions in Mice
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[1] E. Appella,et al. Cell Type- and Promoter-specific Roles of Ser18 Phosphorylation in Regulating p53 Responses* , 2003, Journal of Biological Chemistry.
[2] J. Cleveland,et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. , 2003, Cancer cell.
[3] D. Baltimore,et al. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. , 2003, Genes & development.
[4] D. Purdie,et al. Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer , 2002, Nature Genetics.
[5] F. McCormick,et al. The RB and p53 pathways in cancer. , 2002, Cancer cell.
[6] Ettore Appella,et al. ATM Mediates Phosphorylation at Multiple p53 Sites, Including Ser46, in Response to Ionizing Radiation* , 2002, The Journal of Biological Chemistry.
[7] E. Appella,et al. Mutation of Mouse p53 Ser23 and the Response to DNA Damage , 2002, Molecular and Cellular Biology.
[8] K. Vousden. Activation of the p53 tumor suppressor protein. , 2002, Biochimica et biophysica acta.
[9] S. Schreiber,et al. ATR Is Not Required for p53 Activation but Synergizes with p53 in the Replication Checkpoint* , 2002, The Journal of Biological Chemistry.
[10] D. Woods,et al. C-Terminal Ubiquitination of p53 Contributes to Nuclear Export , 2001, Molecular and Cellular Biology.
[11] R. Copeland,et al. Human mdm2 Mediates Multiple Mono-ubiquitination of p53 by a Mechanism Requiring Enzyme Isomerization* , 2001, The Journal of Biological Chemistry.
[12] M. Serrano,et al. Tumor susceptibility of p21(Waf1/Cip1)-deficient mice. , 2001, Cancer research.
[13] T. Burns,et al. Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo , 2001, Oncogene.
[14] S. Lowe,et al. Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[15] E. Appella,et al. Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[16] F. McCormick,et al. Opposing Effects of Ras on p53 Transcriptional Activation of mdm2 and Induction of p19ARF , 2000, Cell.
[17] G. Wahl,et al. A transactivation-deficient mouse model provides insights into Trp53 regulation and function , 2000, Nature Genetics.
[18] S. Sukumar,et al. Compromised HOXA5 function can limit p53 expression in human breast tumours , 2000, Nature.
[19] N D Marchenko,et al. Death Signal-induced Localization of p53 Protein to Mitochondria , 2000, The Journal of Biological Chemistry.
[20] D. Green,et al. p53 Induces Apoptosis by Caspase Activation through Mitochondrial Cytochrome c Release* , 2000, The Journal of Biological Chemistry.
[21] S. Elledge,et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. , 2000, Science.
[22] Y Taya,et al. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. , 2000, Genes & development.
[23] D. Meek,et al. Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2 , 1999, The EMBO journal.
[24] M. Nakanishi,et al. Role of Human Cds1 (Chk2) Kinase in DNA Damage Checkpoint and Its Regulation by p53* , 1999, The Journal of Biological Chemistry.
[25] Yoichi Taya,et al. ATM associates with and phosphorylates p53: mapping the region of interaction , 1999, Nature Genetics.
[26] P. Howley,et al. Mutations in serines 15 and 20 of human p53 impair its apoptotic activity , 1999, Oncogene.
[27] N. Perkins,et al. Transcriptional Cross Talk between NF-κB and p53 , 1999, Molecular and Cellular Biology.
[28] Y. Taya,et al. Requirement of ATM in Phosphorylation of the Human p53 Protein at Serine 15 following DNA Double-Strand Breaks , 1999, Molecular and Cellular Biology.
[29] M. Kubbutat,et al. Regulation of p53 Function and Stability by Phosphorylation , 1999, Molecular and Cellular Biology.
[30] Y Taya,et al. A role for ATR in the DNA damage-induced phosphorylation of p53. , 1999, Genes & development.
[31] L. Donehower,et al. Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[32] F. Kashanchi,et al. Phosphorylation of p53 Serine 15 Increases Interaction with CBP* , 1998, The Journal of Biological Chemistry.
[33] Y Taya,et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. , 1998, Science.
[34] D. Pinkel,et al. Retention of wild‐type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation , 1998, The EMBO journal.
[35] J L Cleveland,et al. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. , 1998, Genes & development.
[36] A. Carr,et al. Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[37] B. Lehnert,et al. Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints , 1998, Oncogene.
[38] G. Wahl,et al. ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage , 1998, Current Biology.
[39] Y Taya,et al. DNA damage induces phosphorylation of the amino terminus of p53. , 1997, Genes & development.
[40] Richard A. Ashmun,et al. Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19 ARF , 1997, Cell.
[41] Yoichi Taya,et al. DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2 , 1997, Cell.
[42] T. Jacks,et al. Deletion of p21 cannot substitute for p53 loss in rescue of mdm2 null lethality , 1997, Nature Genetics.
[43] Stephen N. Jones,et al. Regulation of p53 stability by Mdm2 , 1997, Nature.
[44] M. Oren,et al. Mdm2 promotes the rapid degradation of p53 , 1997, Nature.
[45] P. Leder,et al. Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints. , 1997, Cancer research.
[46] G. Wahl,et al. The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[47] P. Leder,et al. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[48] M. Minden,et al. Translational regulation of human p53 gene expression. , 1996, The EMBO journal.
[49] G. Wahl,et al. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. , 1996, Genes & development.
[50] Guillermina Lozano,et al. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53 , 1995, Nature.
[51] Lawrence A. Donehower,et al. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53 , 1995, Nature.
[52] James Brugarolas,et al. Radiation-induced cell cycle arrest compromised by p21 deficiency , 1995, Nature.
[53] Stephen J. Elledge,et al. Mice Lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control , 1995, Cell.
[54] K. Khanna,et al. Nature of G1/S cell cycle checkpoint defect in ataxia-telangiectasia. , 1995, Oncogene.
[55] P. Tegtmeyer,et al. Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation. , 1995, Cancer research.
[56] J. Trent,et al. WAF1, a potential mediator of p53 tumor suppression , 1993, Cell.
[57] S. Elledge,et al. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases , 1993, Cell.
[58] L. Donehower,et al. Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice , 1993, Nature Genetics.
[59] L. Donehower,et al. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. , 1993, Oncogene.
[60] A. Levine,et al. Mapping of the p53 and mdm-2 interaction domains. , 1993, Molecular and cellular biology.
[61] M. Fiscella,et al. Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression. , 1993, Oncogene.
[62] Scott W. Lowe,et al. p53 is required for radiation-induced apoptosis in mouse thymocytes , 1993, Nature.
[63] Bert Vogelstein,et al. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 , 1993, Nature.
[64] C. Purdie,et al. Thymocyte apoptosis induced by p53-dependent and independent pathways , 1993, Nature.
[65] B. Vogelstein,et al. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia , 1992, Cell.
[66] L. Donehower,et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours , 1992, Nature.
[67] Y Taya,et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. , 1998, Science.
[68] C. Deng,et al. Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways , 1998, Nature Genetics.
[69] I. Krantz,et al. KILLER/DR5 is a DNA damage–inducible p53–regulated death receptor gene , 1997, Nature Genetics.