lectric field distribution in a finite-volume head model of deep brain stimulation

This study presents a whole-head finite element model of deep brain stimulation to examine the effect of electrical grounding, the finite conducting volume of the head, and scalp, skull and cerebrospinal fluid layers. The impedance between the stimulating and reference electrodes in the whole-head model was found to lie within clinically reported values when the reference electrode was incorporated on a localized surface in the model. Incorporation of the finite volume of the head and inclusion of surrounding outer tissue layers reduced the magnitude of the electric field and activating function by approximately 20% in eep brain stimulation

[1]  C. McIntyre,et al.  Sources and effects of electrode impedance during deep brain stimulation , 2006, Clinical Neurophysiology.

[2]  F. Rattay,et al.  Modeling the excitation of fibers under surface electrodes , 1988, IEEE Transactions on Biomedical Engineering.

[3]  Jaimie M. Henderson,et al.  Patient-specific analysis of the volume of tissue activated during deep brain stimulation , 2007, NeuroImage.

[4]  C. McIntyre,et al.  Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both , 2004, Clinical Neurophysiology.

[5]  Allen Taflove,et al.  Incorporation of the electrode–electrolyte interface into finite-element models of metal microelectrodes , 2008, Journal of neural engineering.

[6]  Alvaro Pascual-Leone,et al.  Brain Stimulation in Poststroke Rehabilitation , 2007, Cerebrovascular Diseases.

[7]  W E Bolch,et al.  A revised dosimetric model of the adult head and brain. , 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[8]  Ljubomir Manola,et al.  Anodal vs cathodal stimulation of motor cortex: A modeling study , 2007, Clinical Neurophysiology.

[9]  Bart Nuttin,et al.  Chronaxie calculated from current–duration and voltage–duration data , 2000, Journal of Neuroscience Methods.

[10]  L. Geddes,et al.  The specific resistance of biological material—A compendium of data for the biomedical engineer and physiologist , 1967, Medical and biological engineering.

[11]  Jean Delbeke,et al.  Simulation of intra-orbital optic nerve electrical stimulation , 2005, Medical and Biological Engineering and Computing.

[12]  J. B. Ranck,et al.  THE SPECIFIC IMPEDANCE OF THE DORSAL COLUMNS OF CAT: AN INISOTROPIC MEDIUM. , 1965, Experimental neurology.

[13]  W. Grill,et al.  Electrical properties of implant encapsulation tissue , 2006, Annals of Biomedical Engineering.

[14]  R. W. Lau,et al.  The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues. , 1996, Physics in medicine and biology.

[15]  F. Rattay.  Analysis of Models for External Stimulation of Axons , 1986, IEEE Transactions on Biomedical Engineering.

[16]  Y. Agid,et al.  Tourette’s syndrome and deep brain stimulation , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[17]  A. Lozano,et al.  Deep Brain Stimulation for Treatment-Resistant Depression , 2005, Neuron.

[18]  J. Volkmann,et al.  Introduction to the programming of deep brain stimulators , 2002, Movement disorders : official journal of the Movement Disorder Society.

[19]  E. Hollander,et al.  Experimental therapeutics for refractory obsessive-compulsive disorder: translational approaches and new somatic developments. , 2008, The Mount Sinai journal of medicine, New York.

[20]  Cees J. Stok,et al.  The influence of model parameters on EEG/MEG single dipole source estimation , 1987, IEEE Transactions on Biomedical Engineering.

[21]  D. B. Heppner,et al.  Considerations of quasi-stationarity in electrophysiological systems. , 1967, The Bulletin of mathematical biophysics.

[22]  C. Heinrichs,et al.  Hyperplasia of the Subcutaneous Adipose Tissue Is the Primary Histopathologic Abnormality in Lipedematous Scalp , 2003, The American Journal of dermatopathology.

[23]  Warren M. Grill,et al.  Selection of stimulus parameters for deep brain stimulation , 2004, Clinical Neurophysiology.

[24]  Sung June Kim,et al.  Three-dimensional analysis of electrode behavior in a human cochlear model. , 2005, Medical engineering & physics.

[25]  Markus Zahn,et al.  Three-dimensional head model Simulation of transcranial magnetic stimulation , 2004, IEEE Transactions on Biomedical Engineering.

[26]  R. Bayford,et al.  Quantifying the effects of the electrode–brain interface on the crossing electric currents in deep brain recording and stimulation , 2008, Neuroscience.

[27]  M. Rosenfeld,et al.  Correlation between skull thickness asymmetry and scalp potential estimated by a numerical model of the head , 1995, IEEE Transactions on Biomedical Engineering.

[28]  R. Alterman,et al.  Deep brain stimulation for torsion dystonia in children , 2007, Child's Nervous System.

[29]  Frank Rattay,et al.  Effective electrode configuration for selective stimulation with inner eye prostheses , 2004, IEEE Transactions on Biomedical Engineering.

[30]  D. Stegeman,et al.  Finite limb dimensions and finite muscle length in a model for the generation of electromyographic signals. , 1991, Electroencephalography and clinical neurophysiology.

[31]  Peter N Steinmetz,et al.  Assessing the direct effects of deep brain stimulation using embedded axon models , 2007, Journal of neural engineering.

[32]  S. Hemm,et al.  Deep brain stimulation in movement disorders: stereotactic coregistration of two-dimensional electrical field modeling and magnetic resonance imaging. , 2005, Journal of neurosurgery.

[33]  R. Fisher,et al.  Brain stimulation for epilepsy , 2005, Nature Clinical Practice Neurology.

[34]  C. McIntyre,et al.  How Does Deep Brain Stimulation Work? Present Understanding and Future Questions , 2004, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[35]  J. Iles,et al.  Simple models of stimulation of neurones in the brain by electric fields. , 2005, Progress in biophysics and molecular biology.

[36]  David R. Wozny,et al.  The electrical conductivity of human cerebrospinal fluid at body temperature , 1997, IEEE Transactions on Biomedical Engineering.

[37]  Richard Bayford,et al.  The peri-electrode space is a significant element of the electrode–brain interface in deep brain stimulation: A computational study , 2007, Brain Research Bulletin.

[38]  Xuefeng F. Wei,et al.  Current density distributions, field distributions and impedance analysis of segmented deep brain stimulation electrodes , 2005, Journal of neural engineering.

[39]  Karin Wårdell,et al.  The effect of cystic cavities on deep brain stimulation in the basal ganglia: a simulation-based study , 2006, Journal of neural engineering.

[40]  C. McIntyre,et al.  Cellular effects of deep brain stimulation: model-based analysis of activation and inhibition. , 2004, Journal of neurophysiology.