Potential of breath and skin analysis for monitoring blood glucose concentration in diabetes

The ability to monitor blood glucose noninvasively has long been a goal of those with diabetes, due to the pain and inconvenience of current blood glucose monitoring devices. This article investigates the potential for monitoring compounds in breath and emitted through skin for inferring blood glucose concentration. Potential markers and an assessment of their suitability for noninvasive monitoring are discussed. The varying technologies developed for monitoring volatile organic compounds in breath and from the skin of diabetics and their suitability for development as a hand-held device is reviewed. The potential exists for the use of breath and skin monitoring as an alternative to blood glucose, but it may take years to collect sufficient clinical data for robust correlations to be possible.

[1]  T. Tsuda,et al.  Relationship between skin acetone and blood β-hydroxybutyrate concentrations in diabetes , 2006 .

[2]  H. M. Saraoglu,et al.  Determination of diabetic blood glucose value from breath odor using QCM sensor based Electronic Nose , 2010, 2010 15th National Biomedical Engineering Meeting.

[3]  David Smith,et al.  A longitudinal study of ethanol and acetaldehyde in the exhaled breath of healthy volunteers using selected-ion flow-tube mass spectrometry. , 2006, Rapid communications in mass spectrometry : RCM.

[4]  Sotiris E Pratsinis,et al.  Si:WO(3) Sensors for highly selective detection of acetone for easy diagnosis of diabetes by breath analysis. , 2010, Analytical chemistry.

[5]  M. Davidson.  Novel Noninvasive Breath Test Method for Screening Individuals at Risk for Diabetes , 2009, Diabetes Care.

[6]  Tianshu Wang,et al.  Generation of volatile compounds on mouth exposure to urea and sucrose: implications for exhaled breath analysis , 2006, Physiological measurement.

[7]  David Zhang,et al.  Diabetes Identification and Classification by Means of a Breath Analysis System , 2010, ICMB.

[8]  D. Blake,et al.  Improved predictive models for plasma glucose estimation from multi-linear regression analysis of exhaled volatile organic compounds. , 2009, Journal of applied physiology.

[9]  A. B. Robinson,et al.  Gas chromatography of volatiles from breath and urine. , 1972, Analytical chemistry.

[10]  M. Hlastala,et al.  Measuring airway exchange of endogenous acetone using a single-exhalation breathing maneuver. , 2006, Journal of applied physiology.

[11]  S J Pöppl,et al.  Predicting Type 2 diabetes using an electronic nose-based artificial neural network analysis. , 2002, Diabetes, nutrition & metabolism.

[12]  Julian King,et al.  A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone , 2010, Journal of mathematical biology.

[13]  L. Howie,et al.  Self-Monitoring of Blood Glucose by Adults With Diabetes in the United States Population , 1993, Diabetes Care.

[14]  M. Evans,et al.  An exploratory comparative study of volatile compounds in exhaled breath and emitted by skin using selected ion flow tube mass spectrometry. , 2008, Rapid communications in mass spectrometry : RCM.

[15]  A. Gelperin,et al.  Volatile metabolic monitoring of glycemic status in diabetes using electronic olfaction. , 2004, Diabetes technology & therapeutics.

[16]  M. Phillips,et al.  Increased breath biomarkers of oxidative stress in diabetes mellitus. , 2004, Clinica chimica acta; international journal of clinical chemistry.

[17]  I. Ray,et al.  Detection of biomarker in breath: A step towards noninvasive diabetes monitoring , 2008 .

[18]  M. Hlastala,et al.  The kinetics of transdermal ethanol exchange. , 2006, Journal of applied physiology.

[19]  H. Arnqvist,et al.  Concentrations of acetone in venous blood samples from drunk drivers, type-I diabetic outpatients, and healthy blood donors. , 1993, Journal of analytical toxicology.

[20]  M. Shepherd,et al.  A Study on Breath Acetone in Diabetic Patients Using a Cavity Ringdown Breath Analyzer: Exploring Correlations of Breath Acetone With Blood Glucose and Glycohemoglobin A1C , 2010, IEEE Sensors Journal.

[21]  David Smith,et al.  A longitudinal study of ammonia, acetone and propanol in the exhaled breath of 30 subjects using selected ion flow tube mass spectrometry, SIFT-MS , 2006, Physiological measurement.

[22]  David Smith,et al.  Acetone, ammonia and hydrogen cyanide in exhaled breath of several volunteers aged 4–83 years , 2007, Journal of breath research.

[23]  H. Byun,et al.  Analysis of diabetic patient's breath with conducting polymer sensor array , 2005 .

[24]  I. Raz,et al.  Assessment of insulin resistance by a 13C glucose breath test: a new tool for early diagnosis and follow-up of high-risk patients , 2010, Nutrition journal.

[25]  S. Cunnane,et al.  Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals. , 2002, The American journal of clinical nutrition.

[26]  Jianzhong Li,et al.  Determination of acetone in breath , 2005 .

[27]  H. Paretzke,et al.  Differences in exhaled gas profiles between patients with type 2 diabetes and healthy controls. , 2010, Diabetes technology & therapeutics.

[28]  T R Fraser,et al.  Breath acetone and blood sugar measurements in diabetes. , 1969, Clinical science.

[29]  R. Summers,et al.  Detection of isopropyl alcohol in a patient with diabetic ketoacidosis. , 2000, Journal of Emergency Medicine.

[30]  Q. Zhang,et al.  Diagnosis of diabetes by image detection of breath using gas-sensitive LAPS. , 2000, Biosensors & bioelectronics.

[31]  Stephen C Cunnane,et al.  Breath acetone as a measure of systemic ketosis assessed in a rat model of the ketogenic diet. , 2002, Clinical chemistry.

[32]  Christopher Walton,et al.  Breath acetone concentration decreases with blood glucose concentration in type I diabetes mellitus patients during hypoglycaemic clamps , 2009, Journal of breath research.

[33]  David Smith,et al.  Time variation of ammonia, acetone, isoprene and ethanol in breath: a quantitative SIFT-MS study over 30 days. , 2003, Physiological measurement.

[34]  D. Blake,et al.  Exhaled methyl nitrate as a noninvasive marker of hyperglycemia in type 1 diabetes , 2007, Proceedings of the National Academy of Sciences.

[35]  Kiyokatsu Jinno,et al.  Breath acetone analysis with miniaturized sample preparation device: in-needle preconcentration and subsequent determination by gas chromatography-mass spectroscopy. , 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[36]  R. Hoeldtke,et al.  Acetone Metabolism During Diabetic Ketoacidosis , 1982, Diabetes.

[37]  Novel Noninvasive Breath Test Method for Screening Individuals at Risk for Diabetes , 2009, Diabetes Care.

[38]  山根 則夫.  Relationship between skin acetone and blood β-hydroxybutyrate concentrations in diabetes , 2006 .

[39]  Malina K. Storer,et al.  Accurate, reproducible measurement of acetone concentration in breath using selected ion flow tube-mass spectrometry , 2010, Journal of breath research.

[40]  J. Pawliszyn,et al.  Application of membrane extraction with sorbent interface for breath analysis. , 2010, Methods in molecular biology.

[41]  X. Zhang,et al.  Determination of acetone in human breath by gas chromatography-mass spectrometry and solid-phase microextraction with on-fiber derivatization. , 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[42]  Simone Meinardi,et al.  Breath ethanol and acetone as indicators of serum glucose levels: an initial report. , 2005, Diabetes technology & therapeutics.

[43]  P. Španěl,et al.  Trace gases in breath of healthy volunteers when fasting and after a protein-calorie meal: a preliminary study. , 1999, Journal of applied physiology.