A new mitochondrion targetable fluorescent probe for carbon monoxide-specific detection and live cell imaging.

A new mitochondrion targetable molecular probe for carbon monoxide (CO)-specific detection based on palladium-free mediated opening of spirolactam was designed. The turn-on red fluorescence caused by CO enables a safe and powerful method for unravelling the function of CO in biological systems to be established.

[1]  Xiaohua Ren,et al.  A metal-free near-infrared fluorescent probe for tracking the glucose-induced fluctuations of carbon monoxide in living cells and zebrafish , 2019, Sensors and Actuators B: Chemical.

[2]  Jin Zhou,et al.  A red lysosome-targeted fluorescent probe for carboxylesterase detection and bioimaging , 2019, Journal of Materials Chemistry B.

[3]  T. James,et al.  Ratiometric fluorescent probe for sensing Streptococcus mutans glucosyltransferase, a key factor in the formation of dental caries. , 2019, Chemical communications.

[4]  Jong Seung Kim,et al.  A ratiometric fluorescent probe for detecting hypochlorite in the endoplasmic reticulum. , 2019, Chemical communications.

[5]  Jong Seung Kim,et al.  Dual-functional fluorescent molecular rotor for endoplasmic reticulum microviscosity imaging during reticulophagy. , 2019, Chemical communications.

[6]  T. James,et al.  NAG-targeting fluorescence based probe for precision diagnosis of kidney injury. , 2019, Chemical communications.

[7]  T. James,et al.  Molecular Design Strategy to Construct the Near-Infrared Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2J2. , 2018, Journal of the American Chemical Society.

[8]  Brian W Michel,et al.  Olefin Metathesis-Based Fluorescent Probes for the Selective Detection of Ethylene in Live Cells. , 2018, Journal of the American Chemical Society.

[9]  Bin Yang,et al.  Mitochondria-targeted near-infrared fluorescent probe for the detection of carbon monoxide in vivo. , 2018, Talanta.

[10]  Zuokai Wang,et al.  A highly specific and sensitive ratiometric fluorescent probe for carbon monoxide and its bioimaging applications , 2018 .

[11]  Jin Zhou,et al.  Intracellular endogenous glutathione detection and imaging by a simple and sensitive spectroscopic off-on probe. , 2018, The Analyst.

[12]  Guoqiang Feng,et al.  A readily available colorimetric and near-infrared fluorescent turn-on probe for detection of carbon monoxide in living cells and animals , 2018 .

[13]  Koushik Dhara,et al.  A New Lysosome-Targetable Turn-On Fluorogenic Probe for Carbon Monoxide Imaging in Living Cells. , 2018, Analytical chemistry.

[14]  Wei Chen,et al.  A General Strategy for Development of Near-Infrared Fluorescent Probes for Bioimaging. , 2017, Angewandte Chemie.

[15]  Andrew J. P. White,et al.  Ex Vivo Tracking of Endogenous CO with a Ruthenium(II) Complex. , 2017, Journal of the American Chemical Society.

[16]  Weiying Lin,et al.  Rational Design of a Robust Fluorescent Probe for the Detection of Endogenous Carbon Monoxide in Living Zebrafish Embryos and Mouse Tissue. , 2017, Angewandte Chemie.

[17]  Development of an indicator for the direct visualization of radical intermediates in organic reactions. , 2017, Chemical communications.

[18]  B. Wang,et al.  pH-Sensitive metal-free carbon monoxide prodrugs with tunable and predictable release rates. , 2017, Chemical communications.

[19]  Guoqiang Feng,et al.  Lighting up carbon monoxide in living cells by a readily available and highly sensitive colorimetric and fluorescent probe , 2017 .

[20]  Guoqiang Feng,et al.  Allyl Fluorescein Ethers as Promising Fluorescent Probes for Carbon Monoxide Imaging in Living Cells. , 2017, Analytical chemistry.

[21]  Jin Zhou,et al.  Carbon dots doped with heteroatoms for fluorescent bioimaging: a review , 2017, Microchimica Acta.

[22]  J. Niu,et al.  Fluorescent Probe Based on Azobenzene-Cyclopalladium for the Selective Imaging of Endogenous Carbon Monoxide under Hypoxia Conditions. , 2016, Analytical chemistry.

[23]  Guoqiang Feng,et al.  Readily Available Fluorescent Probe for Carbon Monoxide Imaging in Living Cells. , 2016, Analytical chemistry.

[24]  Bo Tang,et al.  An Ultrasensitive Cyclization-Based Fluorescent Probe for Imaging Native HOBr in Live Cells and Zebrafish. , 2016, Angewandte Chemie.

[25]  Wei Chen,et al.  A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals. , 2016, Angewandte Chemie.

[26]  Wei Chen,et al.  The Development of Fluorescent Probes for Visualizing Intracellular Hydrogen Polysulfides. , 2015, Angewandte Chemie.

[27]  Xinghui Gao,et al.  HOCl can appear in the mitochondria of macrophages during bacterial infection as revealed by a sensitive mitochondrial-targeting fluorescent probe† †Electronic supplementary information (ESI) available: Experimental section and supporting figures. See DOI: 10.1039/c5sc01562f Click here for additiona , 2015, Chemical science.

[28]  Kai Li,et al.  Reversible photochromic system based on rhodamine B salicylaldehyde hydrazone metal complex. , 2014, Journal of the American Chemical Society.

[29]  Kaibo Zheng,et al.  Lighting up carbon monoxide: fluorescent probes for monitoring CO in living cells. , 2013, Angewandte Chemie.

[30]  Christopher J. Chang,et al.  A reaction-based fluorescent probe for selective imaging of carbon monoxide in living cells using a palladium-mediated carbonylation. , 2012, Journal of the American Chemical Society.

[31]  Huimin Ma,et al.  Rhodamine B thiolactone: a simple chemosensor for Hg2+ in aqueous media. , 2008, Chemical communications.

[32]  P. Naughton,et al.  Cardioprotective Actions by a Water‐Soluble Carbon nMonoxide‐Releasing Molecule , 2003, Circulation research.

[33]  Detlef Keller,et al.  Palladium--a review of exposure and effects to human health. , 2002, International journal of hygiene and environmental health.

[34]  L. Wu,et al.  Reduced vasorelaxant effect of carbon monoxide in diabetes and the underlying mechanisms. , 2001, Diabetes.

[35]  P. Barnes,et al.  Exhaled carbon monoxide levels elevated in diabetes and correlated with glucose concentration in blood: a new test for monitoring the disease? , 1999, Chest.

[36]  J. Bünger,et al.  Cyto- and genotoxic effects of coordination complexes of platinum, palladium and rhodium in vitro , 1996, International archives of occupational and environmental health.

[37]  J. Wataha,et al.  Biological effects of palladium and risk of using palladium in dental casting alloys. , 1996, Journal of oral rehabilitation.