Описание клинического случая развития воспалительной миофибробластической опухоли печени у пациента раннего возраста

The inflammatory myofibroblastic tumor (IMT) is an extremely rare type of liver tumors in young children. This article presents a clinical case of the development of IMT of the liver in 11-month-old child with the detected chimeric TPM3ex6 / ALKex20 transcript. State-of-the-art data on the clinical presentation of IMT, histological and molecular genetic characteristics of the tumor, differential diagnosis of hepatic masses depending on the level of alpha-fetoprotein, the principles of treatment of IMT, based on a review of the scientific literature, including data on the effectiveness of ALK inhibitors are described.

[1]  M. Lim,et al.  Targeting ALK With Crizotinib in Pediatric Anaplastic Large Cell Lymphoma and Inflammatory Myofibroblastic Tumor: A Children's Oncology Group Study. , 2017, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[2]  C. Strahlendorf,et al.  ETV6-NTRK3 Is Expressed in a Subset of ALK-Negative Inflammatory Myofibroblastic Tumors , 2016, The American journal of surgical pathology.

[3]  S. S. St. Peter,et al.  Inflammatory myofibroblastic tumors in children. , 2016, Journal of Pediatric Surgery.

[4]  C. Antonescu,et al.  Molecular Characterization of Inflammatory Myofibroblastic Tumors With Frequent ALK and ROS1 Gene Fusions and Rare Novel RET Rearrangement , 2015, The American journal of surgical pathology.

[5]  N. Volchenko,et al.  Воспалительная миофибробластическая опухоль молочной железы , 2015 .

[6]  P. Stephens,et al.  Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions. , 2014, Cancer discovery.

[7]  Sudha Nagarajan,et al.  Inflammatory Myofibroblastic Tumor of the Liver in Children , 2013, Journal of pediatric gastroenterology and nutrition.

[8]  J. Maris,et al.  Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study. , 2013, The Lancet. Oncology.

[9]  C. Fletcher,et al.  WHO classification of tumours of soft tissue and bone , 2013 .

[10]  L. Brugières.  Clinical Presentation and Diagnosis , 2011 .

[11]  W. Lau,et al.  Inflammatory Myofibroblastic Tumor of the Liver: A Cohort Study , 2010, World Journal of Surgery.

[12]  G. Toogood,et al.  Inflammatory pseudotumours of the liver: a spectrum of presentation and management options. , 2009, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[13]  Yasunori Sato,et al.  Pathological classification of hepatic inflammatory pseudotumor with respect to IgG4-related disease , 2007, Modern Pathology.

[14]  Y. Sakamoto,et al.  Spontaneous Regression of Inflammatory Pseudotumor of the Liver: Report of Three Cases , 2007, Surgery Today.

[15]  Y. Mizuguchi,et al.  Inflammatory pseudotumor in the Spiegel lobe of the liver of an elderly woman. , 2005, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.

[16]  S. L. Lee,et al.  Hepatic inflammatory pseudotumor: case report, review of the literature, and a proposal for morphologic classification , 2001, Pediatric Surgery International.

[17]  M. Makuuchi,et al.  Inflammatory pseudotumors of the liver: prevalence and clinical impact in surgical patients. , 2001, Hepato-gastroenterology.

[18]  M. Tsou,et al.  Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor: A Distinctive Low-Grade Malignant Intra-abdominal Neoplasm With Consistent Epstein–Barr Virus Association , 2001, The American journal of surgical pathology.

[19]  S. Perkins,et al.  ALK1 and p80 Expression and Chromosomal Rearrangements Involving 2p23 in Inflammatory Myofibroblastic Tumor , 2001, Modern Pathology.

[20]  P. D. Dal Cin,et al.  TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. , 2000, The American journal of pathology.

[21]  L. Memeo,et al.  Inflammatory pseudotumour of the liver--evidence for malignant transformation. , 1999, Pathology, research and practice.

[22]  T. Ogawa,et al.  A case of inflammatory pseudotumor of the liver causing elevated serum CA19-9 levels , 1998, American Journal of Gastroenterology.

[23]  G. Cimino,et al.  Inflammatory pseudotumour of the liver with malignant transformation. Report of two cases. , 1996, The Italian journal of gastroenterology.

[24]  Louis P. Dehner,et al.  Extrapulmonary Inflammatory Myofibroblastic Tumor (Inflammatory Pseudotumor) A Clinicopathologic and Immunohistochemical Study of 84 Cases , 1995, The American journal of surgical pathology.

[25]  F. Brunello,et al.  Inflammatory pseudotumour of the liver: diagnosis by fine needle biopsy in two cases and a review of the literature. , 1994, The Italian journal of gastroenterology.

[26]  H. W. Baker,et al.  TOTAL RIGHT HEPATIC LOBECTOMY.: REPORT OF A CASE , 1953, Annals of surgery.