论文信息 - Tolerance to electroacupuncture and its cross tolerance to morphine.

Tolerance to electroacupuncture and its cross tolerance to morphine.

Abstract Electroacupuncture (EA) applied to both legs of the rat for 30 min (1session) raised the average tail flick latency to 89% above the control level. Repeated electroacupuncture for 6 sessions, with 30 min between successive sessions, resulted in a gradual decline in the hypoalgesic effect. The time-course of the development and disappearance of acupuncture tolerance was studied. A bidirectional cross-tolerance between electroacupuncture and morphine points to the similarity between the underlying mechanisms of electroacupuncture hypoalgesia and morphine analgesia.

[1] R. Wurtman,et al. A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the rat brain. , 1967, Life sciences.

[2] H. Loh,et al. Physical dependence of opiate-like peptides. , 1976, Science.

[3] J. Han,et al. Central neurotransmitters and acupuncture analgesia. , 1980, The American journal of Chinese medicine.

[4] E. Hulme,et al. Induction of tolerance to the analgesic action of lipotropin C-Fragment , 1976, Nature.

[5] Y. Jacquet. Opiate effects after adrenocorticotropin or beta-endorphin injection in the periaqueductal gray matter of rats. , 1978, Science.

[6] H. Loh,et al. Simultaneous quantitative assessment of morphine tolerance and physical dependence. , 1969, The Journal of pharmacology and experimental therapeutics.

[7] R. Hayes,et al. Stimulation-produced analgesia: development of tolerance and cross-tolerance to morphine. , 1975, Science.

[8] H. Jisheng,et al. Rat tail flick acupuncture analgesia model. , 1979, Chinese medical journal.

[9] Y. Hosobuchi,et al. Pain relief by electrical stimulation of the central gray matter in humans and its reversal by naloxone. , 1977, Science.