A Universal Signature in Whole Genomes

Genomes are replete with duplicated sequences in the form of paralogs, transposons, pseudogenes, simple repeats, and others. To understand the origin of this phenomenon we did a systematic study of occurrence frequencies of short words in all extant complete genomes and found a common pattern of duplications in complete genomes so clear and pronounced that it allows all the genomes except one to be placed in a single class expressed by an extremely simple formula. Our analysis including extensive computer simulation in growth of DNA sequences shows that the formation of the class may be attributed to a universal genome growth mechanism in which maximally stochastic segmental duplication is the major mode of growth.

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