Synthesis and characterization of biologically active flurbiprofen amide derivatives as selective prostaglandin-endoperoxide synthase II inhibitors: In vivo anti-inflammatory activity and molecular docking.

[1]  Zainab,et al.  Bio-Oriented Synthesis of Novel (S)-Flurbiprofen Clubbed Hydrazone Schiff’s Bases for Diabetic Management: In Vitro and In Silico Studies , 2022, Pharmaceuticals.

[2]  A. Alqahtani,et al.  Analgesic and anti-inflammatory effects and safety profile of Cucurbita maxima and Cucumis sativus seeds , 2021, Saudi journal of biological sciences.

[3]  Yun-Li Zhao,et al.  Diverse isoquinolines with anti-inflammatory and analgesic bioactivities from Hypecoum erectum. , 2021, Journal of ethnopharmacology.

[4]  M. Ellis,et al.  Post-Mastectomy Pain Syndrome: Defining Perioperative Etiologies to Guide New Methods of Prevention for Plastic Surgeons , 2020, World journal of plastic surgery.

[5]  Saqib Ali,et al.  15-LOX Inhibitors: Biochemical Evaluation of Flurbiprofen and its Derivatives , 2020 .

[6]  Kyung-Tae Lee,et al.  Anti-inflammatory potential of Patrineolignan B isolated from Patrinia scabra in LPS-stimulated macrophages via inhibition of NF-κB, AP-1, and JAK/STAT pathways. , 2020, International immunopharmacology.

[7]  Yong Deng,et al.  Flurbiprofen-chalcone hybrid Mannich base derivatives as balanced multifunctional agents against Alzheimer's disease: Design, synthesis and biological evaluation. , 2019, Bioorganic chemistry.

[8]  A. Alam,et al.  Flurbiprofen derivatives as novel α-amylase inhibitors: Biology-oriented drug synthesis (BIODS), in vitro, and in silico evaluation. , 2018, Bioorganic chemistry.

[9]  H. K. Vivek,et al.  Multi-targeted dihydrazones as potent biotherapeutics. , 2018, Bioorganic chemistry.

[10]  B. Sudarshan,et al.  Development of piperazine-1-carbothioamide chitosan silver nanoparticles (P1C-Tit*CAgNPs) as a promising anti-inflammatory candidate: a molecular docking validation. , 2018, MedChemComm.

[11]  H. K. Vivek,et al.  Synthesis of benzo[d]thiazole-hydrazone analogues: molecular docking and SAR studies of potential H+/K+ ATPase inhibitors and anti-inflammatory agents. , 2017, MedChemComm.

[12]  Toni Giorgino,et al.  PlayMolecule ProteinPrepare: A Web Application for Protein Preparation for Molecular Dynamics Simulations , 2017, J. Chem. Inf. Model..

[13]  Xun Sun,et al.  Novel flurbiprofen derivatives with improved brain delivery: synthesis, in vitro and in vivo evaluations , 2016, Drug delivery.

[14]  A. Bekhit,et al.  Evaluation of anti-inflammatory, analgesic activities, and side effects of some pyrazole derivatives , 2016, Inflammopharmacology.

[15]  J. Robson,et al.  The dangers of NSAIDs: look both ways. , 2016, The British journal of general practice : the journal of the Royal College of General Practitioners.

[16]  Alan A. Wilson,et al.  Inhibition of fatty acid amide hydrolase and cyclooxygenase by the N-(3-methylpyridin-2-yl)amide derivatives of flurbiprofen and naproxen. , 2013, European journal of pharmacology.

[17]  A. Cataldi,et al.  New Flurbiprofen Derivatives: Synthesis, Membrane Affinity and Evaluation of in Vitro Effect on β-Amyloid Levels , 2013, Molecules.

[18]  Mostafa A. Hussein,et al.  Design, synthesis and molecular docking of some new 1,2,4-triazolobenzimidazol-3-yl acetohydrazide derivatives with anti-inflammatory-analgesic activities , 2013, Archives of pharmacal research.

[19]  H. Omar,et al.  Design, synthesis and pharmacological evaluation of omeprazole-like agents with anti-inflammatory activity. , 2013, Bioorganic & medicinal chemistry.

[20]  Patrick Richard,et al.  The economic costs of pain in the United States. , 2012, The journal of pain : official journal of the American Pain Society.

[21]  P. Palumbo,et al.  Clinical pharmacology of non-steroidal anti-inflammatory drugs: a review. , 2012, Anti-inflammatory & anti-allergy agents in medicinal chemistry.

[22]  Poonam Sharma,et al.  Anti-Inflammatory Activity of Lactobacillus on Carrageenan-Induced Paw Edema in Male Wistar Rats , 2012, International journal of inflammation.

[23]  M. A. van de Laar,et al.  Non-Steroidal Anti-Inflammatory Drugs: An Overview of Cardiovascular Risks , 2010, Pharmaceuticals.

[24]  K. M. Hosamani,et al.  In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives. , 2010, European journal of medicinal chemistry.

[25]  C. Dinarello.  Anti-inflammatory Agents: Present and Future , 2010, Cell.

[26]  S. Sagdinc,et al.  Spectroscopic and DFT studies of flurbiprofen as dimer and its Cu(II) and Hg(II) complexes. , 2009, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[27]  M. Shaaban,et al.  Synthesis and analgesic/anti-inflammatory evaluation of fused heterocyclic ring systems incorporating phenylsulfonyl moiety. , 2008, Bioorganic & medicinal chemistry.

[28]  C. Bertram,et al.  Withdrawal of COX-2 selective inhibitors rofecoxib and valdecoxib: impact on NSAID and gastroprotective drug prescribing and utilization* , 2007, Current medical research and opinion.

[29]  H. Geerts.  Drug evaluation: (R)-flurbiprofen--an enantiomer of flurbiprofen for the treatment of Alzheimer's disease. , 2007, IDrugs : the investigational drugs journal.

[30]  S. Girardin,et al.  Chronic inflammation: importance of NOD2 and NALP3 in interleukin‐1β generation , 2006 .

[31]  M. Espina,et al.  Flurbiprofen loaded biodegradable nanoparticles for ophtalmic administration. , 2006, Journal of pharmaceutical sciences.

[32]  T. Edwards.  Inflammation, pain, and chronic disease: an integrative approach to treatment and prevention. , 2005, Alternative therapies in health and medicine.

[33]  C. Rao,et al.  NSAIDs and chemoprevention. , 2004, Current cancer drug targets.

[34]  M. Tal.  A role for inflammation in chronic pain , 1999, Current review of pain.

[35]  H. Jun,et al.  Anti-inflammatory activity of ketoprofen gel on carrageenan-induced paw edema in rats. , 1990, Journal of pharmaceutical sciences.

[36]  D. Gowda,et al.  Multi-targeted quinazolinone-Schiff's bases as potent bio-therapeutics , 2020 .

[37]  V. Kepe,et al.  Flurbiprofen derivatives in Alzheimer's disease: synthesis, pharmacokinetic and biological assessment of lipoamino acid prodrugs. , 2008, Bioconjugate chemistry.

[38]  R. Garavito,et al.  Cyclooxygenases: structural, cellular, and molecular biology. , 2000, Annual review of biochemistry.

[39]  K. P. Rakesh,et al.  Synthesis and SAR studies of potent H+/K+-ATPase and anti-inflammatory activities of symmetrical and unsymmetrical urea analogues , 2017, Medicinal Chemistry Research.