Autologous Concentrated Growth Factor Used to Treat Linear Scleroderma En Coup de Sabre: A Case Report

Abstract Linear scleroderma en coup de sabre (LSCS) is a variant of localized scleroderma associated with band-like fibrotic lesions in the frontoparietal area. We report a case of LSCS in a woman who presented with progressive mild hyperchromia on the right side of her forehead, with dermal atrophy and hair and eyebrow loss. After the failure of conservative treatments, the patient responded dramatically to injection of autologous localized concentrated growth factor. After three treatments, the atrophy, stiffness, and angiotelectasis on the affected area had improved. No recurrence was detected 24 months after the last treatment. This is the first study describing the use of autologous concentrated growth factor injection to alleviate clinical symptoms of LSCS. This suggests that concentrated growth factor may be a treatment for LSCS in the clinic.

[1]  Amelia K Hausauer,et al.  The Efficacy of Platelet-Rich Plasma in the Field of Hair Restoration and Facial Aesthetics—A Systematic Review and Meta-analysis , 2019, Journal of cutaneous medicine and surgery.

[2]  H. Jacobe,et al.  Morphea: Current concepts. , 2018, Clinics in dermatology.

[3]  J. Jimenez,et al.  Alopecia Areata: Review of Epidemiology, Clinical Features, Pathogenesis, and New Treatment Options , 2018, International journal of trichology.

[4]  S. Giordano,et al.  Platelet‐rich plasma for androgenetic alopecia: Does it work? Evidence from meta analysis , 2017, Journal of cosmetic dermatology.

[5]  A. Tosti,et al.  Trichoscopic Features of Linear Morphea on the Scalp , 2017, Skin Appendage Disorders.

[6]  E. D. De Jong,et al.  Morphea and Eosinophilic Fasciitis: An Update , 2017, American Journal of Clinical Dermatology.

[7]  M. Worm,et al.  German guidelines for the diagnosis and therapy of localized scleroderma , 2016, Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.

[8]  Yue Sun,et al.  Concentrated growth factor increases Schwann cell proliferation and neurotrophic factor secretion and promotes functional nerve recovery in vivo. , 2016, International journal of molecular medicine.

[9]  K. Yanaba,et al.  Histological features of localized scleroderma ‘en coup de sabre’: a study of 16 cases , 2014, Journal of the European Academy of Dermatology and Venereology : JEADV.

[10]  A. Niţă,et al.  The synergy between lasers and adipose tissues surgery in cervicofacial rejuvenation: histopathological aspects. , 2013, Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie.

[11]  L. Rodella,et al.  Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction , 2011, Microscopy research and technique.

[12]  M. Inglese,et al.  Neurologic manifestations of localized scleroderma , 2008, Neurology.

[13]  H. Plosker,et al.  The use of autologous platelet-rich plasma (platelet gel) and autologous platelet-poor plasma (fibrin glue) in cosmetic surgery. , 2001, Plastic and reconstructive surgery.