THE INFLUENCE OF THE LIVER ON PHENOLSULPHONEPHTHALEIN EXCRETION

The frequent occurrence of low phenolsulphonephthalein excretion in certain persons without suspicion or evidence of renal disease must have attracted the attention of many observers. In our clinic, while studying the excretion of creatinin in health and in disease, a low excretion of phenolsulphonephthalein has been rather frequently observed in patients who excreted creatinin in a normal fashion, whose blood on chemical analysis and whose blood pressure were normal, and whose urine contained no albumin, sugar, casts or other evidence of renal impairment. Further tests in these normal controls showed, at times, a normal excretion of phenolsulphonephthalein, at other times, a marked diminution. 1 The low values in phenolsulphonephthalein excretion were seen more often following intravenous injection, but were also noted at times after intramuscular injections. Six normal persons, showing a two-hour urinary excretion of from 35 to 40 per cent., showed three and four days later an excretion of