Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014.
暂无分享,去创建一个
C. Auffray | E. Silverman | J. Sznajder | J. Roca | J. Sharpe | F. Sanz | L. Furlong | P. Sterk | A. Agustí | M. Puhan | J. Garcia-Aymerich | F. Barbé | J. Antó | J. Escarrabill | R. Faner | E. Barreiro | J. Gea | O. Sibila | E. Monso | J. Dorca | V. Plaza | B. Lindmark | J. Ruiz-manzano | L. Sampietro-Colom | Luis Serrano
[1] P. Poole,et al. Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease. , 2017, The Cochrane database of systematic reviews.
[2] Craig E Wheelock,et al. Network analysis in the investigation of chronic respiratory diseases. From basics to application. , 2014, American journal of respiratory and critical care medicine.
[3] Avrum Spira,et al. Relationship of DNA methylation and gene expression in idiopathic pulmonary fibrosis. , 2014, American journal of respiratory and critical care medicine.
[4] Pablo Villoslada,et al. Modules, networks and systems medicine for understanding disease and aiding diagnosis , 2014, Genome Medicine.
[5] Colm E. Nestor,et al. Targeted omics and systems medicine: personalising care. , 2014, The Lancet. Respiratory medicine.
[6] J. Roca,et al. Network medicine analysis of COPD multimorbidities , 2014, Respiratory Research.
[7] A. Agustí,et al. Network medicine, multimorbidity and the lung in the elderly , 2014, European Respiratory Journal.
[8] N. McElvaney,et al. Ivacaftor: from bench to bedside... and back again. , 2014, American journal of respiratory and critical care medicine.
[9] Russell Bowler,et al. Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD , 2014, BMC Systems Biology.
[10] S. Schneeweiss. Learning from big health care data. , 2014, The New England journal of medicine.
[11] W. Busse,et al. Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. , 2014, The Journal of allergy and clinical immunology.
[12] Gary D Bader,et al. A draft map of the human proteome , 2014, Nature.
[13] V. Roger,et al. From 'solution shop' model to 'focused factory' in hospital surgery: increasing care value and predictability. , 2014, Health affairs.
[14] Christina Kiel,et al. Structure‐energy‐based predictions and network modelling of RASopathy and cancer missense mutations , 2014, Molecular systems biology.
[15] A. Agustí. The path to personalised medicine in COPD , 2014, Thorax.
[16] Christoph Lange,et al. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. , 2014, The Lancet. Respiratory medicine.
[17] Stephanie A. Santorico,et al. Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema , 2014, Thorax.
[18] D. Postma,et al. Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study. , 2014, The Lancet. Respiratory medicine.
[19] Stephen Fairclough,et al. Physiological data must remain confidential , 2014, Nature.
[20] J. Sznajder,et al. Malfolded protein structure and proteostasis in lung diseases. , 2013, American journal of respiratory and critical care medicine.
[21] G. Annas,et al. 23andMe and the FDA. , 2014, New England Journal of Medicine.
[22] Alex Gray,et al. The bottom–up approach to defining life: deciphering the functional organization of biological cells via multi-objective representation of biological complexity from molecules to cells , 2013, Front. Physiol..
[23] R. Varadhan,et al. Benefits and harms of roflumilast in moderate to severe COPD , 2013, Thorax.
[24] Jill P. Mesirov,et al. Criteria for the use of omics-based predictors in clinical trials , 2013, Nature.
[25] Jill P Mesirov,et al. Criteria for the use of omics-based predictors in clinical trials: explanation and elaboration , 2013, BMC Medicine.
[26] F. Sanz,et al. Improving data and knowledge management to better integrate health care and research , 2013, Journal of internal medicine.
[27] T. Maher. Beyond the diagnosis of idiopathic pulmonary fibrosis; the growing role of systems biology and stratified medicine , 2013, Current opinion in pulmonary medicine.
[28] D. Belsky,et al. Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study. , 2013, The Lancet. Respiratory medicine.
[29] J. Gray,et al. The shift to personalised and population medicine , 2013, The Lancet.
[30] Chris Henshall,et al. HEALTH TECHNOLOGY ASSESSMENT, VALUE-BASED DECISION MAKING, AND INNOVATION , 2013, International Journal of Technology Assessment in Health Care.
[31] I. Pavord,et al. Moving from the Oslerian paradigm to the post-genomic era: are asthma and COPD outdated terms? , 2013, Thorax.
[32] B. Nordestgaard,et al. Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease. , 2013, JAMA.
[33] T. Beaty,et al. Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells. , 2013, Genomics.
[34] T. Murdoch,et al. The inevitable application of big data to health care. , 2013, JAMA.
[35] M. Porter,et al. Redesigning primary care: a strategic vision to improve value by organizing around patients' needs. , 2013, Health affairs.
[36] I. Hall,et al. Stratified medicine: drugs meet genetics , 2013, European Respiratory Review.
[37] Charles Auffray,et al. Application of ’omics technologies to biomarker discovery in inflammatory lung diseases , 2013, European Respiratory Journal.
[38] E. Silverman,et al. Developing New Drug Treatments in the Era of Network Medicine , 2013, Clinical pharmacology and therapeutics.
[39] M. Khoury,et al. A Population Perspective on How Personalized Medicine Can Improve Health , 2013 .
[40] F. García Lizana. [European Innovation Partnership on active and healthy ageing]. , 2013, Medicina clinica.
[41] S. Lewitzky,et al. A pharmacogenetic study of ADRB2 polymorphisms and indacaterol response in COPD patients , 2011, The Pharmacogenomics Journal.
[42] R. Varadhan,et al. A framework for organizing and selecting quantitative approaches for benefit-harm assessment , 2012, BMC Medical Research Methodology.
[43] A. Ciechanover,et al. Personalized medicine: the road ahead. , 2012, American journal of respiratory and critical care medicine.
[44] Alvar Agusti,et al. The COPD control panel: towards personalised medicine in COPD , 2012, Thorax.
[45] D. Geman,et al. Computational Medicine: Translating Models to Clinical Care , 2012 .
[46] K. Rabe,et al. Uncovering and tackling Europe's hidden respiratory illness , 2012, The Lancet.
[47] Edwin K Silverman,et al. Network medicine approaches to the genetics of complex diseases. , 2012, Discovery medicine.
[48] L. Smarr. Quantifying your body: a how-to guide from a systems biology perspective. , 2012, Biotechnology journal.
[49] Charles Auffray,et al. Editorial: Systems biology and personalized medicine – the future is now , 2012, Biotechnology journal.
[50] S. Wyke,et al. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study , 2012, The Lancet.
[51] Muin J Khoury,et al. A population approach to precision medicine. , 2012, American journal of preventive medicine.
[52] Courtney Crim,et al. Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype , 2012, PloS one.
[53] P. Sorger,et al. Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks , 2012, Cell.
[54] D. Postma,et al. Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: a Mechanisms of the Development of Allergy (MeDALL) seminar. , 2012, The Journal of allergy and clinical immunology.
[55] Hugo Y. K. Lam,et al. Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes , 2012, Cell.
[56] Ara Darzi,et al. Preparing for precision medicine. , 2012, The New England journal of medicine.
[57] Ben Lehner,et al. Fitness Trade-Offs and Environmentally Induced Mutation Buffering in Isogenic C. elegans , 2012, Science.
[58] J. Schwartz,et al. Expanding the scope of environmental risk assessment to better include differential vulnerability and susceptibility. , 2011, American journal of public health.
[59] Thomas Beyer,et al. Medical imaging in personalised medicine: a white paper of the research committee of the European Society of Radiology (ESR) , 2011, Insights into imaging.
[60] Josep Roca,et al. A Systems Biology Approach Identifies Molecular Networks Defining Skeletal Muscle Abnormalities in Chronic Obstructive Pulmonary Disease , 2011, PLoS Comput. Biol..
[61] L. Hood,et al. Systems medicine and integrated care to combat chronic noncommunicable diseases , 2011, Genome Medicine.
[62] A. Bauer-Mehren,et al. Gene-Disease Network Analysis Reveals Functional Modules in Mendelian, Complex and Environmental Diseases , 2011, PloS one.
[63] F Kauffmann,et al. MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine , 2011, Allergy.
[64] Adnan Custovic,et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. , 2011, The Journal of allergy and clinical immunology.
[65] Ravi Iyengar,et al. Quantitative and Systems Pharmacology in the Post-genomic Era : New Approaches to Discovering Drugs and Understanding Therapeutic , 2011 .
[66] Laura Inés Furlong,et al. DisGeNET: a Cytoscape plugin to visualize, integrate, search and analyze gene-disease networks , 2010, Bioinform..
[67] R. Epstein,et al. Comparative effectiveness and personalized medicine: evolving together or apart? , 2010, Health affairs.
[68] K. Gibert,et al. Integrating clinicians, knowledge and data: expert-based cooperative analysis in healthcare decision support , 2010, Health research policy and systems.
[69] E. Perakslis,et al. Effective knowledge management in translational medicine , 2010, Journal of Translational Medicine.
[70] Teri A Manolio,et al. Genomewide association studies and assessment of the risk of disease. , 2010, The New England journal of medicine.
[71] D. Noble,et al. Systems Biology: An Approach , 2010, Clinical pharmacology and therapeutics.
[72] Brian Godman,et al. Risk sharing arrangements for pharmaceuticals: potential considerations and recommendations for European payers , 2010, BMC health services research.
[73] Charles Auffray,et al. An integrative systems biology approach to understanding pulmonary diseases. , 2010, Chest.
[74] J. Kere,et al. ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responses , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[75] A. Barabasi,et al. Network medicine : a network-based approach to human disease , 2010 .
[76] M. Porter. A strategy for health care reform--toward a value-based system. , 2009, The New England journal of medicine.
[77] S. Tunis,et al. Does comparative-effectiveness research threaten personalized medicine? , 2009, The New England journal of medicine.
[78] M. Vidal,et al. Edgetic perturbation models of human inherited disorders , 2009, Molecular systems biology.
[79] C. Fu,et al. Study on Mass Customization for Knowledge Production and its Operation Mode , 2009 .
[80] Ulrike Held,et al. Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease: the updated BODE index and the ADO index , 2009, The Lancet.
[81] Christina Kiel,et al. Cell Type–Specific Importance of Ras–c-Raf Complex Association Rate Constants for MAPK Signaling , 2009, Science Signaling.
[82] David J. Galas,et al. Systems Biology and Emerging Technologies Will Catalyze the Transition from Reactive Medicine to Predictive, Personalized, Preventive and Participatory (P4) Medicine , 2009 .
[83] K. Shianna,et al. A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci , 2009, PLoS genetics.
[84] J. Ioannidis. Personalized Genetic Prediction: Too Limited, Too Expensive, or Too Soon? , 2009, Annals of Internal Medicine.
[85] L. Hood,et al. Systems medicine: the future of medical genomics and healthcare , 2009, Genome Medicine.
[86] A. Barabasi,et al. Network medicine--from obesity to the "diseasome". , 2007, The New England journal of medicine.
[87] A. Barabasi,et al. Human disease classification in the postgenomic era: A complex systems approach to human pathobiology , 2007, Molecular systems biology.
[88] P. Lansdorp,et al. Telomerase mutations in families with idiopathic pulmonary fibrosis. , 2007, The New England journal of medicine.
[89] Jeremy J. W. Chen,et al. A five-gene signature and clinical outcome in non-small-cell lung cancer. , 2007, The New England journal of medicine.
[90] Barbara Di Ventura,et al. From in vivo to in silico biology and back , 2006, Nature.
[91] Eric J Kunkel,et al. Systems biology in drug discovery. , 2006, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference.
[92] F. Kauffmann,et al. Post-genome respiratory epidemiology: a multidisciplinary challenge , 2004, European Respiratory Journal.
[93] Patricia L. Harris,et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. , 2004, The New England journal of medicine.
[94] Ciro Casanova,et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. , 2004, The New England journal of medicine.
[95] Allen W Cowley. The elusive field of systems biology. , 2004, Physiological genomics.
[96] M H Gail,et al. Weighing the risks and benefits of tamoxifen treatment for preventing breast cancer. , 1999, Journal of the National Cancer Institute.
[97] A. Detsky,et al. Evidence-based medicine. A new approach to teaching the practice of medicine. , 1992, JAMA.
[98] D. Mccormick. Sequence the Human Genome , 1986, Bio/Technology.
[99] A. Gittelsohn,et al. Small Area Variations in Health Care Delivery , 1973, Science.
[100] S. Doll. Smoking and Lung Cancer , 1957, Nature.