Measuring optical temperature coefficients of Intralipid.

The temperature sensitivities of absorption and reduced scattering coefficients in the range 700-1000 nm are determined for the liquid phantom Intralipid using spatially resolved continuous wave measurements. The measurements were conducted on a 10 L heated volume of 1% Intralipid subjected to a 40-30 degrees C cooling regime. The temperature sensitivities of the absorbance coefficients are similar to that expected for pure water. However, the reduced scattering coefficients are more sensitive than can be explained by temperature related density changes, and show an unexpected relationship with wavelength. We have also found that temperature perturbations provide a useful means to evaluate instrument model performance.

[1]  Huafeng Ding,et al.  A primary method for determination of optical parameters of turbid samples and application to intralipid between 550 and 1630 nm. , 2006, Optics express.

[2]  Velocity half-sphere model for multiple light scattering in turbid media. , 2005, Physical review. E, Statistical, nonlinear, and soft matter physics.

[3]  Mamoru Tamura,et al.  Expression of optical diffusion coefficient in high-absorption turbid media , 1997 .

[4]  J. R. Collins Change in the Infra-Red Absorption Spectrum of Water with Temperature , 1925 .

[5]  H. J. van Staveren,et al.  Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm. , 1991, Applied optics.

[6]  Thomas F. Coleman,et al.  A Subspace, Interior, and Conjugate Gradient Method for Large-Scale Bound-Constrained Minimization Problems , 1999, SIAM J. Sci. Comput..

[7]  I. Delfino,et al.  Experimental tests of different solutions to the diffusion equation for optical characterization of scattering media by time-resolved transmittance. , 1999, Applied optics.

[8]  Britton Chance,et al.  PHASE MEASUREMENT OF LIGHT ABSORPTION AND SCATTER IN HUMAN TISSUE , 1998 .

[9]  S L Jacques,et al.  Optical properties of intralipid: A phantom medium for light propagation studies , 1992, Lasers in surgery and medicine.

[10]  M. Nichols,et al.  Design and testing of a white-light, steady-state diffuse reflectance spectrometer for determination of optical properties of highly scattering systems. , 1997, Applied optics.

[11]  Terence I. Quickenden,et al.  Temperature Dependence of the Visible-Near-Infrared Absorption Spectrum of Liquid Water , 2001 .