Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: a study matched for T- and N- classification

[1]  Junichiro Tanaka,et al.  SMAD4 Levels and Allelic Imbalance in 18q21 in Colorectal Cancer , 2006, Clinical Cancer Research.

[2]  H. Nagawa,et al.  Mucinous Colorectal Cancers With Chromosomal Instability: A Biologically Distinct and Aggressive Subtype , 2006, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

[3]  Jukka-Pekka Mecklin,et al.  SMAD4 as a Prognostic Marker in Colorectal Cancer , 2005, Clinical Cancer Research.

[4]  T. Ko,et al.  TGF-β Signaling in Colon Cancer Cells , 2005, World Journal of Surgery.

[5]  C. Bordi,et al.  Association Between Recurrence of Sporadic Colorectal Cancer, High Level of Microsatellite Instability, and Loss of Heterozygosity at Chromosome 18q , 2004, Diseases of the colon and rectum.

[6]  N. Matsubara,et al.  Allelic Loss of a Common Microsatellite Marker MYCL1 , 2004, Clinical Cancer Research.

[7]  C. Morrison,et al.  PTEN mutations are common in sporadic microsatellite stable colorectal cancer , 2004, Oncogene.

[8]  Sanford Markowitz,et al.  TGF-β-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines , 2003, Oncogene.

[9]  P J Catalano,et al.  Molecular predictors of survival after adjuvant chemotherapy for colon cancer. , 2001, The New England journal of medicine.

[10]  A. Maitra,et al.  Loss of Dpc4 expression in colonic adenocarcinomas correlates with the presence of metastatic disease. , 2000, The American journal of pathology.

[11]  J. Cameron,et al.  Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas. , 2000, The American journal of pathology.

[12]  S. Markowitz.  TGF-beta receptors and DNA repair genes, coupled targets in a pathway of human colon carcinogenesis. , 2000, Biochimica et biophysica acta.

[13]  Takeo Iwama,et al.  Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis , 1999, Oncogene.

[14]  P. Vihko,et al.  Loss of heterozygosity at 18q21 is indicative of recurrence and therefore poor prognosis in a subset of colorectal cancers , 1999, British Journal of Cancer.

[15]  H. McLeod,et al.  Tumour markers of prognosis in colorectal cancer , 1999, British Journal of Cancer.

[16]  R. Gafà,et al.  Chromosome 18q allelic loss and prognosis in stage II and III colon cancer , 1998, International journal of cancer.

[17]  D. Chung.  Molecular prognostic markers and colorectal cancer: the search goes on. , 1998, Gastroenterology.

[18]  M. Hawn,et al.  Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancer. , 1998, Gastroenterology.

[19]  J. Fleshman,et al.  Confirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[20]  M. Loda,et al.  The DCC protein and prognosis in colorectal cancer. , 1996, The New England journal of medicine.

[21]  K. Kinzler,et al.  Lessons from Hereditary Colorectal Cancer , 1996, Cell.

[22]  Irene L Andrulis,et al.  MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma , 1996, Cell.

[23]  Scott E. Kern,et al.  Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers , 1996, Nature Genetics.

[24]  J. Arends,et al.  A detailed analysis of K‐ras point mutations in relation to tumor progression and survival in colorectal cancer patients , 1996, International journal of cancer.

[25]  Scott E. Kern,et al.  DPC4, A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1 , 1996, Science.

[26]  J. Eshleman,et al.  Both transforming growth factor-beta and substrate release are inducers of apoptosis in a human colon adenoma cell line. , 1995, Cancer research.

[27]  Z. F. Liu,et al.  Allelic loss of chromosome 18q and prognosis in colorectal cancer. , 1994, The New England journal of medicine.

[28]  Kathleen R. Cho,et al.  The DCC gene: structural analysis and mutations in colorectal carcinomas. , 1994, Genomics.

[29]  J. Benhattar,et al.  Prognostic significance of K-ras mutations in colorectal carcinoma. , 1993, Gastroenterology.

[30]  Kathleen R. Cho,et al.  Identification of a chromosome 18q gene that is altered in colorectal cancers. , 1990, Science.

[31]  Y. Nakamura,et al.  Allelotype of colorectal carcinomas. , 1989, Science.

[32]  Y. Nakamura,et al.  Genetic alterations during colorectal-tumor development. , 1988, The New England journal of medicine.

[33]  T. Ko,et al.  TGF-beta signaling in colon cancer cells. , 2005, World journal of surgery.

[34]  Sanford Markowitz,et al.  TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines. , 2003, Oncogene.