Forensic genetics and ethical, legal and social implications beyond the clinic

Data on human genetic variation help scientists to understand human origins, susceptibility to illness and genetic causes of disease. Destructive episodes in the history of genetic research make it crucial to consider the ethical and social implications of research in genomics, especially human genetic variation. The analysis of ethical, legal and social implications should be integrated into genetic research, with the participation of scientists who can anticipate and monitor the full range of possible applications of the research from the earliest stages. The design and implementation of research directs the ways in which its results can be used, and data and technology, rather than ethical considerations or social needs, drive the use of science in unintended ways. Here we examine forensic genetics and argue that all geneticists should anticipate the ethical and social issues associated with nonmedical applications of genetic variation research.

[1]  Hua Tang,et al.  Categorization of humans in biomedical research: genes, race and disease , 2002, Genome Biology.

[2]  E. Lander.  DNA fingerprinting: the NRC report. , 1993, Science.

[3]  Toshihiro Tanaka.  The International HapMap Project , 2003, Nature.

[4]  Bioethics, Bench, and Bar: Selected Arguments in Landry v. Attorney General , 2000 .

[5]  Helen Reece.  Law and Science , 1987 .

[6]  Bruce Budowle,et al.  Genotype Profiles for Six Population Groups at the 13 CODIS Short Tandem Repeat Core Loci and Other PCRBbased Loci , 1999 .

[7]  Joshua M. Stuart,et al.  Integrating genotype and phenotype information: an overview of the PharmGKB project , 2001, The Pharmacogenomics Journal.

[8]  Eric S. Lander,et al.  DNA fingerprinting on trial , 1989, Nature.

[9]  Marcus W. Feldman,et al.  Race: A genetic melting-pot , 2003, Nature.

[10]  R. J. Herrera,et al.  Polymorphic human specific Alu insertions as markers for human identification , 1995, Electrophoresis.

[11]  The International HapMap Consortium.  Integrating ethics and science in the International HapMap Project , 2004 .

[12]  R. Cooper,et al.  Race and genomics. , 2003, The New England journal of medicine.

[13]  Lundy Braun.  Race, Ethnicity, and Health: Can Genetics Explain Disparities? , 2002, Perspectives in biology and medicine.

[14]  David B. Goldstein,et al.  Population genetic structure of variable drug response , 2001, Nature Genetics.

[15]  F. Collins,et al.  A vision for the future of genomics research , 2003, Nature.

[16]  J. Mountain,et al.  The meanings of "race" in the new genomics: implications for health disparities research. , 2001, Yale journal of health policy, law, and ethics.

[17]  D. Kaye.  DNA Evidence: Probability, Population Genetics, and the Courts , 1993 .

[18]  B. Knoppers,et al.  Ethical issues in international collaborative research on the human genome: the HGP and the HGDP. , 1996, Genomics.

[19]  Eric S. Lander,et al.  DNA fingerprinting dispute laid to rest , 1994, Nature.

[20]  P. Harper.  In the Name of Eugenics , 1987 .

[21]  Joshua Cole,et al.  :Documenting Individual Identity: The Development of State Practices in the Modern World , 2004 .

[22]  M. W. Foster,et al.  Integrating ethics and science in the International HapMap Project , 2004, Nature Reviews Genetics.

[23]  David L. Faigman,et al.  Modern scientific evidence : the law and science of expert testimony , 2006 .

[24]  D. Reich,et al.  Detecting association in a case‐control study while correcting for population stratification , 2001, Genetic epidemiology.

[25]  The proliferation and risks of government DNA databases. , 1997, American journal of public health.

[26]  S. Sherry,et al.  Patterns of human diversity, within and among continents, inferred from biallelic DNA polymorphisms. , 2002, Genome research.

[27]  A. Wood.  Racial differences in the response to drugs--pointers to genetic differences. , 2001, The New England journal of medicine.

[28]  M. W. Foster,et al.  Race, ethnicity, and genomics: social classifications as proxies of biological heterogeneity. , 2002, Genome research.

[29]  M. Cho,et al.  Toward a New Vocabulary of Human Genetic Variation , 2002, Science.

[30]  N. Risch,et al.  The importance of race and ethnic background in biomedical research and clinical practice. , 2003, The New England journal of medicine.

[31]  M. Feldman,et al.  Genetic Structure of Human Populations , 2002, Science.

[32]  Nature Genetics , 1991, Nature.

[33]  I W Evett,et al.  Inferring ethnic origin by means of an STR profile. , 2001, Forensic science international.

[34]  P. Tam.  The International HapMap Consortium. The International HapMap Project (Co-PI of Hong Kong Centre which responsible for 2.5% of genome) , 2003 .

[35]  J. Buckleton,et al.  Logical implications of applying the principles of population genetics to the interpretation of DNA profiling evidence. , 2002, Forensic science international.

[36]  H. Greely.  Human genome diversity: What about the other human genome project? , 2001, Nature Reviews Genetics.

[37]  Pierre Patenaude.  Modern scientific evidence , 2000 .

[38]  T. Liesegang.  Racial differences in the response to drugs—pointers to genetic differences. Wood AJJ.∗∗ N Engl J Med 2001;344:1393–1396. , 2001 .