Sparse interactions: Identifying high-dimensional multilinear systems via compressed sensing

This paper investigates the problem of identifying sparse multilinear systems. Such systems are characterized by multiplicative interactions between the input variables with sparsity meaning that relatively few of all conceivable interactions are present. This problem is motivated by the study of interactions among genes and proteins in living cells. The goal is to develop a sampling/sensing scheme to identify sparse multilinear systems using as few measurements as possible. We derive bounds on the number of measurements required for perfect reconstruction as a function of the sparsity level. Our results extend the notion of compressed sensing from the traditional notion of (linear) sparsity to more refined notions of sparsity encountered in nonlinear systems. In contrast to the linear sparsity models, in the multilinear case the pattern of sparsity may play a role in the sensing requirements.

[1]  Roman Vershynin,et al.  Introduction to the non-asymptotic analysis of random matrices , 2010, Compressed Sensing.

[2]  Robert D. Nowak,et al.  Toeplitz Compressed Sensing Matrices With Applications to Sparse Channel Estimation , 2010, IEEE Transactions on Information Theory.

[3]  Gary D Bader,et al.  The Genetic Landscape of a Cell , 2010, Science.

[4]  Amy S. Espeseth,et al.  Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies , 2009, PLoS pathogens.

[5]  Richard G. Baraniuk,et al.  Probe Design for Compressive Sensing DNA Microarrays , 2008, 2008 IEEE International Conference on Bioinformatics and Biomedicine.

[6]  M. Newton,et al.  Drosophila RNAi screen identifies host genes important for influenza virus replication , 2008, Nature.

[7]  M. Rudelson,et al.  On sparse reconstruction from Fourier and Gaussian measurements , 2008 .

[8]  Babak Hassibi,et al.  Recovering Sparse Signals Using Sparse Measurement Matrices in Compressed DNA Microarrays , 2008, IEEE Journal of Selected Topics in Signal Processing.

[9]  E. Candès The restricted isometry property and its implications for compressed sensing , 2008 .

[10]  R. DeVore,et al.  A Simple Proof of the Restricted Isometry Property for Random Matrices , 2008 .

[11]  E. Candès,et al.  The Dantzig selector: Statistical estimation when P is much larger than n , 2005, math/0506081.

[12]  Robert D. Nowak,et al.  Signal Reconstruction From Noisy Random Projections , 2006, IEEE Transactions on Information Theory.

[13]  Emmanuel J. Candès,et al.  Near-Optimal Signal Recovery From Random Projections: Universal Encoding Strategies? , 2004, IEEE Transactions on Information Theory.

[14]  E. Candès,et al.  Robust uncertainty principles: exact signal reconstruction from highly incomplete frequency information , 2004, IEEE Transactions on Information Theory.

[15]  Svante Janson,et al.  Rademacher chaos: tail estimates versus limit theorems , 2004 .

[16]  Dimitris Achlioptas,et al.  Database-friendly random projections: Johnson-Lindenstrauss with binary coins , 2003, J. Comput. Syst. Sci..

[17]  R. Blei,et al.  Analysis in Integer and Fractional Dimensions: Index , 2001 .

[18]  R. Latala Estimation of moments of sums of independent real random variables , 1997 .

[19]  R. Brualdi,et al.  Regions in the Complex Plane Containing the Eigenvalues of a Matrix , 1994 .