Closing the loop between feasible flux scenario identification for construct evaluation and resolution of realized fluxes via NMR
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[1] B. Palsson,et al. Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110 , 1994, Applied and environmental microbiology.
[2] R. Horst,et al. Global Optimization: Deterministic Approaches , 1992 .
[3] M. Domach,et al. Cell Growth and By‐Product Formation in a Pyruvate Kinase Mutant of E. coli , 2001, Biotechnology progress.
[4] Arne Stolbjerg Drud,et al. CONOPT - A Large-Scale GRG Code , 1994, INFORMS J. Comput..
[5] T Zhu,et al. A metabolic network analysis & NMR experiment design tool with user interface-driven model construction for depth-first search analysis. , 2003, Metabolic engineering.
[6] D. Tempest,et al. Influence of environment on the content and composition of microbial free amino acid pools. , 1970, Journal of general microbiology.
[7] J. Nielsen,et al. Quantitative analysis of metabolic fluxes in Escherichia coli, using two-dimensional NMR spectroscopy and complete isotopomer models. , 1999, Journal of biotechnology.
[8] M. Domach,et al. Simple constrained‐optimization view of acetate overflow in E. coli , 1990, Biotechnology and bioengineering.
[9] S. Cohen,et al. 13C NMR study of the effects of leptin treatment on kinetics of hepatic intermediary metabolism. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[10] M. Domach,et al. Suppressed Acid Formation By Cofeeding of Glucose and Citrate in Bacillus Cultures: Emergence of Pyruvate Kinase as a Potential Metabolic Engineering Site , 1995, Biotechnology progress.
[11] I. Grossmann,et al. Recursive MILP model for finding all the alternate optima in LP models for metabolic networks , 2000 .
[12] J. Villadsen,et al. Modeling isotopomer distributions in biochemical networks using isotopomer mapping matrices. , 1997, Biotechnology and bioengineering.
[13] S. Cohen,et al. 13C NMR study of effects of fasting and diabetes on the metabolism of pyruvate in the tricarboxylic acid cycle and the utilization of pyruvate and ethanol in lipogenesis in perfused rat liver. , 1987, Biochemistry.
[14] R. S. Laundy,et al. Multiple Criteria Optimisation: Theory, Computation and Application , 1989 .
[15] C Phalakornkule,et al. A MILP-based flux alternative generation and NMR experimental design strategy for metabolic engineering. , 2001, Metabolic engineering.
[16] H. Blanch,et al. Using isotopomer path tracing to quantify metabolic fluxes in pathway models containing reversible reactions. , 2001, Biotechnology and bioengineering.