Laryngeal involvement in toxic epidermal necrolysis

Toxic epidermal necrolysis (TEN) represents the most severe form of Stevens-Johnson syndrome (SJS), a mucocutaneous reaction most frequently related to medication use. Mucosal involvement of the oral cavity is a diagnostic criterion of SJS, and involvement of the tracheobronchial mucosa has also been well-documented. To our knowledge, epiglottitis associated with TEN has been reported only once previously. I We report a case of an 8-year-old boy in whom epiglottitis in progression from SJS to TEN developed; we also provide a brief discussion of this clinical entity.

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