In vitro three-dimensional cell cultures for bone sarcomas

[1]  Xiaoying Wang,et al.  A Novel SimpleDrop Chip for 3D Spheroid Formation and Anti-Cancer Drug Assay , 2021, Micromachines.

[2]  G. Domenici,et al.  PDX-Derived Ewing’s Sarcoma Cells Retain High Viability and Disease Phenotype in Alginate Encapsulated Spheroid Cultures , 2021, Cancers.

[3]  C. Canal,et al.  Osteosarcoma tissue-engineered model challenges oxidative stress therapy revealing promoted cancer stem cell properties , 2021, Free radical biology & medicine.

[4]  R. Randall,et al.  Tissue engineered platforms for studying primary and metastatic neoplasm behavior in bone. , 2020, Journal of biomechanics.

[5]  H. Gelderblom,et al.  Selection of Effective Therapies Using Three-Dimensional in vitro Modeling of Chondrosarcoma , 2020, Frontiers in Molecular Biosciences.

[6]  M. Mansournia,et al.  Chitosan applications in studying and managing osteosarcoma. , 2020, International journal of biological macromolecules.

[7]  S. Panseri,et al.  Scaffold-based 3D cellular models mimicking the heterogeneity of osteosarcoma stem cell niche , 2020, Scientific Reports.

[8]  Sreerupa Sarkar,et al.  Comparison of VEGF-A secretion from tumor cells under cellular stresses in conventional monolayer culture and microfluidic three-dimensional spheroid models , 2020, PloS one.

[9]  Handan Acar,et al.  Natural and Synthetic Biomaterials for Engineering Multicellular Tumor Spheroids , 2020, Polymers.

[10]  Walter L. Murfee,et al.  Bioprinting on Live Tissue for Investigating Cancer Cell Dynamics. , 2020, Tissue engineering. Part A.

[11]  Chaofei Yang,et al.  Bone Microenvironment and Osteosarcoma Metastasis , 2020, International journal of molecular sciences.

[12]  Z. Duan,et al.  The role of extracelluar matrix in osteosarcoma progression and metastasis , 2020, Journal of experimental & clinical cancer research : CR.

[13]  Yanchuan Guo,et al.  A GelMA-PEGDA-nHA Composite Hydrogel for Bone Tissue Engineering , 2020, Materials.

[14]  Jui-Sheng Sun,et al.  A Dynamic Hanging-Drop System for Mesenchymal Stem Cell Culture , 2020, International journal of molecular sciences.

[15]  W. Murphy,et al.  Synthetic alternatives to Matrigel , 2020, Nature Reviews Materials.

[16]  Ş. Öztürk,et al.  Development and characterization of cancer stem cell‐based tumoroids as an osteosarcoma model , 2020, Biotechnology and bioengineering.

[17]  L. Virág,et al.  Targeting Nuclear NAD+ Synthesis Inhibits DNA Repair, Impairs Metabolic Adaptation and Increases Chemosensitivity of U-2OS Osteosarcoma Cells , 2020, Cancers.

[18]  S. Costantini,et al.  Inhibiting Monocyte Recruitment to Prevent the Pro-Tumoral Activity of Tumor-Associated Macrophages in Chondrosarcoma , 2020, Cells.

[19]  M. Clench,et al.  Mass spectrometry imaging of endogenous metabolites in response to doxorubicin in a novel 3D osteosarcoma cell culture model. , 2020, Journal of mass spectrometry : JMS.

[20]  L. Mancini,et al.  Analysis of Intracellular Magnesium and Mineral Depositions during Osteogenic Commitment of 3D Cultured Saos2 Cells , 2020, International journal of molecular sciences.

[21]  G. De Rosa,et al.  ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma , 2020, Cells.

[22]  M. Ferrari,et al.  Mesenchymal stromal cells mediated delivery of photoactive nanoparticles inhibits osteosarcoma growth in vitro and in a murine in vivo ectopic model , 2020, Journal of Experimental & Clinical Cancer Research.

[23]  Yusef D. Khesuani,et al.  Scaffold-free and label-free biofabrication technology using levitational assembly in a high magnetic field , 2020, Biofabrication.

[24]  F. Guan,et al.  Dual-enzymatically crosslinked hyaluronic acid hydrogel as a long-time 3D stem cell culture system , 2020, Biomedical materials.

[25]  Gerry L. Koons,et al.  3D Tissue-Engineered Tumor Model for Ewing's Sarcoma That Incorporates Bone-like ECM and Mineralization. , 2020, ACS biomaterials science & engineering.

[26]  Nicholas M. Wragg,et al.  Development of a 3D Tissue‐Engineered Skeletal Muscle and Bone Co‐culture System , 2019, Biotechnology journal.

[27]  Nipha Chaicharoenaudomrung,et al.  Three-dimensional cell culture systems as an in vitro platform for cancer and stem cell modeling , 2019, World journal of stem cells.

[28]  Z. Duan,et al.  Establishment and Characterization of a Recurrent Osteosarcoma Cell Line: OSA 1777 , 2019, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[29]  D. Avrahami,et al.  An Integrated Microfluidics Approach for Personalized Cancer Drug Sensitivity and Resistance Assay , 2019, Advanced biosystems.

[30]  S. Suye,et al.  Geometrically customizable alginate hydrogel nanofibers for cell culture platforms. , 2019, Journal of materials chemistry. B.

[31]  T. Kihara,et al.  Osteogenic cells form mineralized particles, a few μm in size, in a 3D collagen gel culture , 2019, PeerJ.

[32]  Ratna Chakrabarti,et al.  3D porous chitosan-alginate scaffold stiffness promotes differential responses in prostate cancer cell lines. , 2019, Biomaterials.

[33]  A. Mikos,et al.  Mechanically tunable coaxial electrospun models of YAP/TAZ mechanoresponse and IGF-1R activation in osteosarcoma. , 2019, Acta biomaterialia.

[34]  M. Romanucci,et al.  Establishment of three-dimensional canine osteosarcoma cell lines showing vasculogenic mimicry and evaluation of biological properties after treatment with 17-AAG. , 2019, Veterinary and comparative oncology.

[35]  T. Regad,et al.  Cancer Stem Cells and Targeting Strategies , 2019, Cells.

[36]  T. Leichlé,et al.  Water-in-PDMS emulsion templating of highly interconnected porous architectures for 3D cell culture. , 2019, ACS applied materials & interfaces.

[37]  N. Jeon,et al.  3D Microfluidic Bone Tumor Microenvironment Comprised of Hydroxyapatite/Fibrin Composite , 2019, Front. Bioeng. Biotechnol..

[38]  Alireza Shahin-Shamsabadi,et al.  A rapid biofabrication technique for self-assembled collagen-based multicellular and heterogeneous 3D tissue constructs. , 2019, Acta biomaterialia.

[39]  P. Cartron,et al.  Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer , 2019, Biochemical pharmacology.

[40]  Jinmin Zhao,et al.  Impact of Hydrogel Elasticity and Adherence on Osteosarcoma Cells and Osteoblasts , 2019, Advanced healthcare materials.

[41]  C. Albanese,et al.  Human ex vivo 3D bone model recapitulates osteocyte response to metastatic prostate cancer , 2018, Scientific Reports.

[42]  R. Mittal,et al.  Organ‐on‐chip models: Implications in drug discovery and clinical applications , 2018, Journal of cellular physiology.

[43]  Nicholas Light,et al.  Ewing‐like sarcoma: An emerging family of round cell sarcomas , 2018, Journal of cellular physiology.

[44]  S. P. Turner,et al.  Bone Cancer: Diagnosis and Treatment Principles. , 2018, American family physician.

[45]  F. Sbrana,et al.  Spheroid‐based 3D cell cultures identify salinomycin as a promising drug for the treatment of chondrosarcoma , 2018, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[46]  L. Niklason,et al.  Vascularization of Natural and Synthetic Bone Scaffolds , 2018, Cell transplantation.

[47]  S. Guelcher,et al.  3D bone models to study the complex physical and cellular interactions between tumor and the bone microenvironment , 2018, Journal of cellular biochemistry.

[48]  N. Magné,et al.  Biological aspects of chondrosarcoma: Leaps and hurdles. , 2018, Critical reviews in oncology/hematology.

[49]  Lobat Tayebi,et al.  3D printed tissue engineered model for bone invasion of oral cancer. , 2018, Tissue & cell.

[50]  I. Miller,et al.  Comparative proteome analysis of monolayer and spheroid culture of canine osteosarcoma cells. , 2018, Journal of proteomics.

[51]  Gong Cheng,et al.  A Spontaneous 3D Bone-On-a-Chip for Bone Metastasis Study of Breast Cancer Cells. , 2018, Small.

[52]  Tingting Tang,et al.  Engineering 3D approaches to model the dynamic microenvironments of cancer bone metastasis , 2018, Bone Research.

[53]  M. Pierzchalska,et al.  The formation of intestinal organoids in a hanging drop culture , 2018, Cytotechnology.

[54]  L. Raimondi,et al.  Relevance of 3d culture systems to study osteosarcoma environment , 2018, Journal of Experimental & Clinical Cancer Research.

[55]  M. Heymann,et al.  Biology of Bone Sarcomas and New Therapeutic Developments , 2017, Calcified Tissue International.

[56]  Wenmiao Shu,et al.  3D bioactive composite scaffolds for bone tissue engineering , 2017, Bioactive materials.

[57]  G. Fuhrmann,et al.  Combining 2D angiogenesis and 3D osteosarcoma microtissues to improve vascularization , 2017, Experimental cell research.

[58]  M. Heymann,et al.  The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma. , 2017, Cellular immunology.

[59]  J. Chezal,et al.  Proteoglycan-targeting applied to hypoxia-activated prodrug therapy in chondrosarcoma: first proof-of-concept , 2017, Oncotarget.

[60]  R. Hegde,et al.  Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids , 2017, Journal of Experimental & Clinical Cancer Research.

[61]  N. Girard,et al.  Identification of an easy to use 3D culture model to investigate invasion and anticancer drug response in chondrosarcomas , 2017, BMC Cancer.

[62]  J. Chezal,et al.  Development and characterization of a human three-dimensional chondrosarcoma culture for in vitro drug testing , 2017, PloS one.

[63]  M. Reagan,et al.  3d Tissue Engineered In Vitro Models Of Cancer In Bone. , 2017, ACS biomaterials science & engineering.

[64]  Ali Khademhosseini,et al.  Bioprinted Osteogenic and Vasculogenic Patterns for Engineering 3D Bone Tissue , 2017, Advanced healthcare materials.

[65]  R. Hegde,et al.  Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids , 2017, BMC Cancer.

[66]  K. Yip,et al.  Application of Hanging Drop Technique for Kidney Tissue Culture , 2017, Kidney and Blood Pressure Research.

[67]  Minsung Kim,et al.  Monitoring the effects of doxorubicin on 3D-spheroid tumor cells in real-time , 2016, OncoTargets and therapy.

[68]  S. Schleicher,et al.  Arsenic trioxide potentiates the effectiveness of etoposide in Ewing sarcomas. , 2016, International journal of oncology.

[69]  Lianying Guo,et al.  Potential approaches to the treatment of Ewing's sarcoma , 2016, Oncotarget.

[70]  S. Toda,et al.  Progress in cell culture systems for pathological research , 2016, Pathology international.

[71]  S. Etcheverry,et al.  In vitro and in vivo antitumor effects of the VO-chrysin complex on a new three-dimensional osteosarcoma spheroids model and a xenograft tumor in mice , 2016, JBIC Journal of Biological Inorganic Chemistry.

[72]  S. Vatansever,et al.  Synergistic role of three dimensional niche and hypoxia on conservation of cancer stem cell phenotype. , 2016, International journal of biological macromolecules.

[73]  J. Goh,et al.  Three‐dimensional spatial configuration of tumour cells confers resistance to chemotherapy independent of drug delivery , 2016, Journal of tissue engineering and regenerative medicine.

[74]  Florian Engert,et al.  Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency , 2015, Nature Communications.

[75]  Han-Sung Jung,et al.  Spontaneous gene transfection of human bone cells using 3D mineralized alginate-chitosan macrocapsules. , 2015, Journal of biomedical materials research. Part A.

[76]  J. Lefaix,et al.  In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact , 2015, BMC Cancer.

[77]  A. Mikos,et al.  Flow perfusion effects on three-dimensional culture and drug sensitivity of Ewing sarcoma , 2015, Proceedings of the National Academy of Sciences.

[78]  T. Gao,et al.  Associations of chemo- and radio-resistant phenotypes with the gap junction, adhesion and extracellular matrix in a three-dimensional culture model of soft sarcoma , 2015, Journal of experimental & clinical cancer research : CR.

[79]  R. Brown,et al.  3D culture model of fibroblast-mediated collagen creep to identify abnormal cell behaviour , 2015, Biomechanics and modeling in mechanobiology.

[80]  B. Jeong,et al.  PEG-Poly(L-alanine) thermogel as a 3D scaffold of bone-marrow-derived mesenchymal stem cells. , 2015, Macromolecular bioscience.

[81]  Therese Andersen,et al.  3D Cell Culture in Alginate Hydrogels , 2015, Microarrays.

[82]  LaKesla R Iles,et al.  3D tissue-engineered model of Ewing's sarcoma. , 2014, Advanced drug delivery reviews.

[83]  P. Layrolle,et al.  Osteoblastic and osteoclastic differentiation of human mesenchymal stem cells and monocytes in a miniaturized three-dimensional culture with mineral granules. , 2014, Acta biomaterialia.

[84]  Ursula Graf-Hausner,et al.  An in vitro osteosarcoma 3D microtissue model for drug development. , 2014, Journal of biotechnology.

[85]  Martin D. Brennan,et al.  Oxygen control with microfluidics. , 2014, Lab on a chip.

[86]  D. Ingber,et al.  Microfluidic organs-on-chips , 2014, Nature Biotechnology.

[87]  U. Dirksen,et al.  Anchorage-independent growth of Ewing sarcoma cells under serum-free conditions is not associated with stem-cell like phenotype and function. , 2014, Oncology reports.

[88]  G. Vunjak‐Novakovic,et al.  Bioengineered human tumor within a bone niche. , 2014, Biomaterials.

[89]  A. Evdokiou,et al.  SaOS2 Osteosarcoma Cells as an In Vitro Model for Studying the Transition of Human Osteoblasts to Osteocytes , 2014, Calcified Tissue International.

[90]  M. de Rosa,et al.  UPARANT: A Urokinase Receptor–Derived Peptide Inhibitor of VEGF-Driven Angiogenesis with Enhanced Stability and In Vitro and In Vivo Potency , 2014, Molecular Cancer Therapeutics.

[91]  G. Dubini,et al.  A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone. , 2014, Biomaterials.

[92]  M. Pozzobon,et al.  Culturing muscle fibres in hanging drop: A novel approach to solve an old problem , 2014, Biology of the cell.

[93]  Yolonda L Colson,et al.  Embedded multicellular spheroids as a biomimetic 3D cancer model for evaluating drug and drug-device combinations. , 2014, Biomaterials.

[94]  R. Todorova Ewing's sarcoma cancer stem cell targeted therapy. , 2013, Current stem cell research & therapy.

[95]  T. Triche,et al.  Characterization and Drug Resistance Patterns of Ewing's Sarcoma Family Tumor Cell Lines , 2013, PloS one.

[96]  K. Stroka,et al.  Probing cell traction forces in confined microenvironments. , 2013, Lab on a chip.

[97]  M. Heymann,et al.  New chondrosarcoma cell lines and mouse models to study the link between chondrogenesis and chemoresistance , 2013, Laboratory Investigation.

[98]  A. Mikos,et al.  Modeling Ewing sarcoma tumors in vitro with 3D scaffolds , 2013, Proceedings of the National Academy of Sciences.

[99]  D. Maniglio,et al.  Functional role of scaffold geometries as a template for physiological ECM formation: evaluation of collagen 3D assembly , 2013, Journal of tissue engineering and regenerative medicine.

[100]  Muhammad Zaman,et al.  Alteration of Cellular Behavior and Response to PI3K Pathway Inhibition by Culture in 3D Collagen Gels , 2012, PloS one.

[101]  J. Chezal,et al.  Quaternary ammonium-melphalan conjugate for anticancer therapy of chondrosarcoma: in vitro and in vivo preclinical studies , 2012, Investigational New Drugs.

[102]  A. Cleton-Jansen,et al.  Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance. , 2012, Annals of oncology : official journal of the European Society for Medical Oncology.

[103]  H. T. Sasmazel Novel hybrid scaffolds for the cultivation of osteoblast cells. , 2011, International journal of biological macromolecules.

[104]  M. Heymann,et al.  The Bone Niche of Chondrosarcoma: A Sanctuary for Drug Resistance, Tumour Growth and also a Source of New Therapeutic Targets , 2011, Sarcoma.

[105]  R. Foty A simple hanging drop cell culture protocol for generation of 3D spheroids. , 2011, Journal of visualized experiments : JoVE.

[106]  S. Stringer,et al.  No haploinsufficiency but loss of heterozygosity for EXT in multiple osteochondromas. , 2010, The American journal of pathology.

[107]  A. Uchida,et al.  Three-dimensional alginate spheroid culture system of murine osteosarcoma. , 2009, Oncology reports.

[108]  B. Reed,et al.  The Preparation of Drosophila Embryos for Live-Imaging Using the Hanging Drop Protocol , 2009, Journal of visualized experiments : JoVE.

[109]  P. Hogendoorn,et al.  A chondrogenic gene expression signature in mesenchymal stem cells is a classifier of conventional central chondrosarcoma , 2008, The Journal of pathology.

[110]  G. Ligresti,et al.  Extracellular Matrix: A Matter of Life and Death , 2008, Connective tissue research.

[111]  O. Delattre,et al.  Mesenchymal stem cell features of Ewing tumors. , 2007, Cancer cell.

[112]  H. Kleinman,et al.  Matrigel: basement membrane matrix with biological activity. , 2005, Seminars in cancer biology.

[113]  Pierre Weiss,et al.  Three-dimensional culture and differentiation of human osteogenic cells in an injectable hydroxypropylmethylcellulose hydrogel. , 2005, Biomaterials.

[114]  J. Chluba,et al.  3-D surface charges modulate protrusive and contractile contacts of chondrosarcoma cells. , 2003, Cell motility and the cytoskeleton.

[115]  Martin Fussenegger,et al.  Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types. , 2003, Biotechnology and bioengineering.

[116]  R. Jain,et al.  Role of extracellular matrix assembly in interstitial transport in solid tumors. , 2000, Cancer research.

[117]  M. Padrines,et al.  Inhibition of Apatite Formation by Vitronectin , 2000, Connective tissue research.

[118]  G. Daculsi,et al.  Effects of fibronectin on hydroxyapatite formation. , 1999, Journal of inorganic biochemistry.

[119]  G. Daculsi,et al.  Apatite precipitation after incubation of biphasic calcium-phosphate ceramic in various solutions: influence of seed species and proteins. , 1998, Journal of biomedical materials research.

[120]  M. Mison,et al.  Osteosarcoma , 1985, The Lancet.

[121]  S. W. Potter,et al.  Development of mouse embryos in hanging drop culture , 1985, The Anatomical record.

[122]  M. Romsdahl,et al.  Prognostic factors in chondrosarcoma of bone. A clinicopathologic analysis with emphasis on histologic grading , 1977, Cancer.

[123]  A. Cabrera,et al.  EWING'S SARCOMA. , 1964, Surgery, gynecology & obstetrics.

[124]  R. G. Harrison The outgrowth of the nerve fiber as a mode of protoplasmic movement. , 1910, The Journal of experimental zoology.

[125]  K. Bussard,et al.  Novel Techniques to Study the Bone-Tumor Microenvironment. , 2020, Advances in experimental medicine and biology.

[126]  Jinmin Zhao,et al.  Untangling the response of bone tumor cells and bone forming cells to matrix stiffness and adhesion ligand density by means of hydrogels. , 2019, Biomaterials.

[127]  W. Chow Chondrosarcoma: biology, genetics, and epigenetics. , 2018, F1000Research.

[128]  G. Vunjak‐Novakovic,et al.  Biomechanical regulation of drug sensitivity in an engineered model of human tumor. , 2018, Biomaterials.

[129]  Zuzana Koledová,et al.  3D Cell Culture: An Introduction. , 2017, Methods in molecular biology.

[130]  E. Lipke,et al.  PEG-fibrinogen hydrogels for three-dimensional breast cancer cell culture. , 2017, Journal of biomedical materials research. Part A.

[131]  A. Piotrowska,et al.  Growth Inhibition of Osteosarcoma Cell Lines in 3D Cultures: Role of Nitrosative and Oxidative Stress. , 2016, Anticancer research.

[132]  G. Vunjak‐Novakovic,et al.  Bioengineered Models of Solid Human Tumors for Cancer Research. , 2016, Methods in molecular biology.

[133]  S. Tay,et al.  Microfluidic cell culture. , 2014, Current opinion in biotechnology.

[134]  Guang Zhou,et al.  CANCER STEM CELLS IN OSTEOSARCOMA. , 2013, Case orthopaedic journal.

[135]  Eleonora Carletti,et al.  Scaffolds for tissue engineering and 3D cell culture. , 2011, Methods in molecular biology.

[136]  A. Poustka,et al.  Subtractive gene expression profiling of articular cartilage and mesenchymal stem cells: serpins as cartilage-relevant differentiation markers. , 2008, Osteoarthritis and cartilage.

[137]  Shang-Tian Yang,et al.  Effects of Three‐Dimensional Culturing on Osteosarcoma Cells Grown in a Fibrous Matrix: Analyses of Cell Morphology, Cell Cycle, and Apoptosis , 2003, Biotechnology progress.