The History of Tissue Engineering and Regenerative Medicine in Perspective

The artificial generation of tissues, organs, or even more complex living organisms was throughout the history of mankind a matter of myth and dream. During the last decades this vision became feasible and has been recently introduced in clinical medicine. Tissue engineering and regenerative medicine are terms for the field in biomedicine that deal with the transformation of these fundamental ideas to practical approaches. Several aspects of generating new tissues and organs out of small pieces of living specimens are now scientifically solved, but at this point it is unknown how much impact these new approaches will have on clinical medicine in the future. In this respect it seems important to recapitulate from where the visions and the work came, in order to speculate or predict where tissue engineering and regenerative medicine will head.

[1]  I. Wilmut,et al.  "Viable Offspring Derived from Fetal and Adult Mammalian Cells" (1997), by Ian Wilmut et al. , 2014 .

[2]  J. Witkowski.  Alexis Carrel and the mysticism of tissue culture. , 1979, Medical History.

[3]  J. Vacanti,et al.  Tissue engineering : Frontiers in biotechnology , 1993 .

[4]  J. H. Harrison,et al.  Successful homotransplantation of the human kidney between identical twins. , 1956, Journal of the American Medical Association.

[5]  R. Virchow,et al.  Die Cellularpathologie in ihrer Begründung auf physiologische und pathologische Gewebelehre , 1861 .

[6]  M. Wadman.  Cloning special: Dolly: a decade on , 2007, Nature.

[7]  Molenaar Jc,et al.  [From the library of the Netherlands Journal of Medicine. Rudolf Virchow: Die Cellularpathologie in ihrer Begründung auf physiologische und pathologische Gewebelehre; 1858]. , 2003 .

[8]  F. Mangoldt,et al.  Die Ueberhäutung von Wundflächen und Wundhöhlen durch Epithelaussaat, eine neue Methode der Transplantation1) , 1895 .

[9]  I. Wilmut,et al.  Cell plasticity: Flexible arrangement , 2003, Nature.

[10]  Ross G. Harrison.  The outgrowth of the nerve fiber as a mode of protoplasmic movement. , 1910 .

[11]  R A Good,et al.  Cellular engineering. , 1977, Clinical bulletin.

[12]  C. Ljunggren.  Von der Fähigkeit des Hautepithels, ausserhalb des Organismus sein Leben zu behalten, mit Berücksichtigung der Transplantation , 1898, Deutsche Zeitschrift für Chirurgie.

[13]  L. Girard,et al.  False teeth of the Roman world , 1998, Nature.

[14]  Naohiro Terada,et al.  Stem Cell Plasticity, Beyond Alchemy , 2004, International journal of hematology.

[15]  M. Sefton,et al.  Tissue engineering. , 1998, Journal of cutaneous medicine and surgery.

[16]  J. Hunter.  The natural history of the human teeth. , 2009 .

[17]  H. B. Fell,et al.  Tissue culture and its contribution to biology and medicine. , 1972, The Journal of experimental biology.

[18]  Antonios G Mikos,et al.  Strategic directions in tissue engineering. , 2007, Tissue engineering.

[19]  J. H. Harrison,et al.  Successful Homotransplantation of the Human Kidney Between Identical Twins , 1956 .

[20]  A. Carrel,et al.  CULTIVATION OF TISSUES IN VITRO AND ITS TECHNIQUE , 1911, The Journal of experimental medicine.