An intelligent electronic capsule system for automated detection of gastrointestinal bleeding

In clinical practice, examination of the hemorrhagic spot (HS) remains difficult. In this paper, we describe a remote controlled capsule (RCC) micro-system with an automated, color-based sensor to identify and localize the HS of the gastrointestinal (GI) tract. In vitro testing of the detecting sensor demonstrated that it was capable of discriminating mimetic intestinal fluid (MIF) with and without the hemoglobin (Hb) when the concentration of Hb in MIF was above 0.05 g/ml. Therefore, this RCC system is able to detect the relatively accurate location of the HS in the GI tract.

[1]  W. Selby,et al.  Antegrade Double Balloon Enteroscopy for Continued Obscure Gastrointestinal Bleeding Following Push Enteroscopy: Is There A Role? , 2010, Digestive Diseases and Sciences.

[2]  Karen Willcox,et al.  Kinetics and kinematics for translational motions in microgravity during parabolic flight. , 2009, Aviation, space, and environmental medicine.

[3]  Zbyněk Svoboda,et al.  Wireless Video Capsule Enteroscopy in Preclinical Studies: Methodical Design of Its Applicability in Experimental Pigs , 2009, Digestive Diseases and Sciences.

[4]  guo-sHu Huang,et al.  Unusual complication of superior mesenteric artery syndrome: spontaneous upper gastrointestinal bleeding with hypovolemic shock. , 2009, Journal of the Chinese Medical Association : JCMA.

[5]  Vijay P. Singh,et al.  The evaluation and management of obscure and occult gastrointestinal bleeding , 2009, Abdominal Imaging.

[6]  C. Ball,et al.  The use of a gamma probe and radioactive technetium to identify obscure gastrointestinal bleeding. , 2008, American journal of surgery.

[7]  You-Ming Li,et al.  OMOM capsule endoscopy in diagnosis of small bowel disease , 2008, Journal of Zhejiang University SCIENCE B.

[8]  Z. Liao,et al.  Clinical Application of OMOM Capsule Endoscopy in China: A Review of 1,068 Cases , 2008 .

[9]  Wensheng Hou,et al.  Wearable magnetic locating and tracking system for MEMS medical capsule , 2008 .

[10]  H. Ogata,et al.  Clinical impact of a newly developed capsule endoscope: usefulness of a real-time image viewer for gastric transit abnormality , 2008, Journal of Gastroenterology.

[11]  N. Reddy,et al.  Capsule endoscopy: current status in obscure gastrointestinal bleeding. , 2007, World journal of gastroenterology.

[12]  J. Ryan,et al.  Use of Provocative Angiography to Localize Site in Recurrent Gastrointestinal Bleeding , 2007, CardioVascular and Interventional Radiology.

[13]  Arianna Menciassi,et al.  Wireless capsule endoscopy: from diagnostic devices to multipurpose robotic systems , 2007, Biomedical microdevices.

[14]  J. Barkin,et al.  Obscure gastrointestinal bleeding: diagnostic and therapeutic approach. , 2007, Journal of clinical gastroenterology.

[15]  D. Margolin,et al.  Implications of negative technetium 99m-labeled red blood cell scintigraphy in patients presenting with lower gastrointestinal bleeding. , 2007, American journal of surgery.

[16]  Robert Puers,et al.  An inductive power link for a wireless endoscope. , 2007, Biosensors & bioelectronics.

[17]  Dirk Jansen,et al.  A Small High Performance Microprocessor Core Sirius for Embedded Low Power Designs, Demonstrated in a Medical Mass Application of an Electronic Pill(EPill®) , 2007, IESS.

[18]  J. Parra,et al.  Ulcerative Jejunoileitis: A Complication of Celiac Sprue Simulating Crohn’s Disease Diagnosed with Capsule Endoscopy (PillCam) , 2007, Digestive Diseases and Sciences.

[19]  Osman Ersoy,et al.  How much helpful is the capsule endoscopy for the diagnosis of small bowel lesions? , 2006, World journal of gastroenterology.

[20]  B. Petersen,et al.  ASGE Technology Status Evaluation Report: wireless capsule endoscopy. , 2006, Gastrointestinal endoscopy.

[21]  M. Delvaux,et al.  Capsule endoscopy in 2005: facts and perspectives. , 2006, Best practice & research. Clinical gastroenterology.

[22]  A. Gossum,et al.  Diagnostic efficacy of push-enteroscopy and long-term follow-up of patients with small bowel angiodysplasias , 1996, Digestive Diseases and Sciences.

[23]  F. Keller,et al.  Value of angiography in diagnosis and therapy of acute upper gastrointestinal hemorrhage , 1981, Digestive Diseases and Sciences.

[24]  P. Marteau,et al.  Clinical impact of push enteroscopy in patients with gastrointestinal bleeding of unknown origin. , 2004, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[25]  A. Singer Value of CT in localizing site of gastrointestinal hemorrhage following negative angiography , 2004, Abdominal Imaging.

[26]  K. Walley,et al.  The evaluation and management of shock. , 2003, Clinics in chest medicine.

[27]  A. Uehara,et al.  Capsule endoscope NORIKA system , 2002, Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy.

[28]  G. Olds The clinical utility of technetium 99m-labeled bleeding scans in the evaluation of acute lower GI hemorrhage , 2002 .

[29]  P. Mathur,et al.  Upper gastrointestinal bleeding: Etiology and management , 2002, Indian journal of pediatrics.

[30]  P. Swain,et al.  Wireless capsule endoscopy. , 2002, The Israel Medical Association journal : IMAJ.

[31]  G. Iddan,et al.  Wireless capsule endoscopy , 2003, Gut.

[32]  B. Lewis,et al.  AGA technical review on the evaluation and management of occult and obscure gastrointestinal bleeding. , 2000, Gastroenterology.

[33]  S. How,et al.  Ischemic Colitis as a cause of massive lower gastrointestinal bleeding and peritonitis , 1989, Diseases of the colon and rectum.