Relationship of cigarette smoking, alcohol use, recreational exercise and obesity with serum lipid atherogenicity: a study of self-defense officials in Japan.

We investigated the relationship of cigarette smoking, alcohol use, recreational exercise and obesity with serum lipid atherogenicity because of paucity of epidemiological studies. The subjects were 2,228 male officials of the Self-Defense Forces in Japan, who were aged 49-55 years and received a preretirement health examination in the period from 1991 to 1992. A self-administered questionnaire was used to ascertain cigarette smoking, alcohol use and recreational exercise. Serum total cholesterol (TC) and low-density-lipoprotein cholesterol (LDL-C) were increased with increasing levels of body mass index (BMI) and waist-to-hip ratio (WHR), and decreased with increasing levels of cigarette smoking and alcohol use. Serum high-density-lipoprotein cholesterol (HDL-C) was positively associated with alcohol use and recreational exercise, and negatively associated with cigarette smoking, BMI and WHR. BMI and alcohol use were most strongly associated with both LDL-C/HDL-C and TC/HDL-C ratios with BMI in an atherogenic direction and alcohol use in an antiatherogenic direction. Recreational exercise was weakly associated with less atherogenic lipid profile. BMI was the strongest determinant of serum lipid atherogenicity whereas alcohol use was most antiatherogenic. WHR was less important than BMI in the determination of serum lipid atherogenicity in Japanese men.

[1]  D. Gelskey,et al.  Is noncentral obesity metabolically benign? Implications for prevention from a population survey. , 1995, JAMA.

[2]  L. Bausserman,et al.  Relations of body fat and fat distribution to the serum lipid, apolipoprotein and insulin concentrations of Samoan men and women. , 1995, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[3]  D. H. Williams,et al.  Association of high-density-lipoprotein cholesterol with mortality and other risk factors for major chronic noncommunicable diseases in samples of US and Russian men. , 1995, Annals of epidemiology.

[4]  S. Kono,et al.  Gallstone disease among Japanese men in relation to obesity, glucose intolerance, exercise, alcohol use, and smoking. , 1995, Scandinavian journal of gastroenterology.

[5]  H. Ueshima,et al.  Alcohol intake and serum lipids in a Japanese population. , 1994, International journal of epidemiology.

[6]  S. Kono,et al.  Obesity and Adenomatous Polyps of the Sigmoid Colon , 1994, Japanese journal of cancer research : Gann.

[7]  A. Deev,et al.  Increased risk of coronary heart disease death in men with low total and low-density lipoprotein cholesterol in the Russian Lipid Research Clinics Prevalence Follow-up Study. , 1993, Circulation.

[8]  M. Carroll,et al.  Serum total cholesterol: HDL cholesterol ratios in US white and black adults by selected demographic and socioeconomic variables (HANES II). , 1991, American journal of public health.

[9]  M. Criqui,et al.  Lipoproteins as mediators for the effects of alcohol consumption and cigarette smoking on cardiovascular mortality: results form the Lipid Research Clinics Follow-up Study. , 1987, American journal of epidemiology.

[10]  G. Burke,et al.  Adverse influences of alcohol, tobacco, and oral contraceptive use on cardiovascular risk factors during transition to adulthood. , 1987, American journal of epidemiology.

[11]  S. Grundy,et al.  Cardiovascular and risk factor evaluation of healthy American adults. A statement for physicians by an Ad Hoc Committee appointed by the Steering Committee, American Heart Association. , 1987, Circulation.

[12]  S. Haffner,et al.  Do Upper-Body and Centralized Adiposity Measure Different Aspects of Regional Body-Fat Distribution? Relationship to Non-Insulin-Dependent Diabetes Mellitus, Lipids, and Lipoproteins , 1987, Diabetes.

[13]  W. Castelli,et al.  Summary Estimates of Cholesterol Used to Predict Coronary Heart Disease , 1983, Circulation.

[14]  D. Ashby,et al.  Blood lipids in middle-aged British men. , 1983, British heart journal.

[15]  D. Jacobs,et al.  The effect of alcohol on serum high density lipoprotein (HDL). A controlled experiment. , 1983, Atherosclerosis.

[16]  G. Heiss,et al.  Alcohol Intake, Cigarette Smoking and Plasma Lipids and Lipoproteins in 12–19‐year‐old Children: The Collaborative Lipid Research Clinics Prevalence Study , 1981, Circulation.

[17]  S. Hulley,et al.  Alcohol and High‐density Lipoprotein Cholesterol: Causal Inference From Diverse Study Designs , 1981, Circulation.

[18]  N. Ernst,et al.  Alcohol and High‐density Lipoprotein Cholesterol , 1981, Circulation.

[19]  R. Rauramaa,et al.  Effect of moderate physical exercise on serum lipoproteins. A controlled clinical trial with special reference to serum high-density lipoproteins. , 1979, Circulation.

[20]  P. Sorlie,et al.  Relation of lipids, weight and physical activity to incidence of coronary heart disease: the Puerto Rico heart study. , 1978, The American journal of cardiology.

[21]  H. Okabe,et al.  Simultaneous determination of serum cholesterol in high- and low-density lipoproteins with use of heparin, Ca2+, and an anion-exchange resin. , 1978, Clinical chemistry.

[22]  S B Hulley,et al.  HDL Cholesterol and Other Lipids in Coronary Heart Disease: The Cooperative Lipoprotein Phenotyping Study , 1977, Circulation.

[23]  P. Fu,et al.  Enzymatic determination of total serum cholesterol. , 1974, Clinical chemistry.

[24]  G Bucolo,et al.  Quantitative determination of serum triglycerides by the use of enzymes. , 1973, Clinical chemistry.

[25]  R. Levy,et al.  Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. , 1972, Clinical chemistry.

[26]  W. Haskell.  Exercise-induced changes in plasma lipids and lipoproteins. , 1984, Preventive medicine.

[27]  S. Hulley,et al.  Alcohol and high-density lipoprotein cholesterol: causal inference from diverse study designs. , 1981, Circulation.