Formation of an N-formylkynurenine-derived fluorophore and its use for measuring indoleamine 2,3-dioxygenase 1 activity
暂无分享,去创建一个
B. Palmer | J. Jamie | J. Flanagan | L. Ching | P. Tomek | Sai Fung | D. J. Bridewell
[1] P. O'dwyer,et al. Pharmacodynamic assessment of INCB024360, an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), in advanced cancer patients. , 2012 .
[2] S. Wang,et al. Upregulated Expression of Indoleamine 2, 3-Dioxygenase in Primary Breast Cancer Correlates with Increase of Infiltrated Regulatory T Cells In Situ and Lymph Node Metastasis , 2011, Clinical & developmental immunology.
[3] G. Prendergast,et al. Cancer: Why tumours eat tryptophan , 2011, Nature.
[4] Emma Lloyd Raven,et al. The Mechanism of Formation of N-Formylkynurenine by Heme Dioxygenases , 2011, Journal of the American Chemical Society.
[5] K. Chida,et al. Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer. , 2010, Lung cancer.
[6] S. Rutella,et al. Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds , 2010, Expert opinion on therapeutic patents.
[7] H. Kajiyama,et al. Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma. , 2009, Gynecologic oncology.
[8] C. L. Costantino,et al. Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival , 2009, Cell cycle.
[9] Qian Wang,et al. Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. , 2009, Journal of medicinal chemistry.
[10] H. Ball,et al. Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway. , 2009, The international journal of biochemistry & cell biology.
[11] L. Bubendorf,et al. High expression of indoleamine 2,3-dioxygenase gene in prostate cancer. , 2008, European journal of cancer.
[12] Judith M. LaLonde,et al. Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase. , 2008, Journal of medicinal chemistry.
[13] G. Prendergast. Immune escape as a fundamental trait of cancer: focus on IDO , 2008, Oncogene.
[14] Judith M. LaLonde,et al. Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. , 2008, Journal of medicinal chemistry.
[15] I. Melero,et al. Immunosuppression routed via the kynurenine pathway: a biochemical and pathophysiologic approach. , 2008, Advances in clinical chemistry.
[16] G. Prendergast,et al. Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses. , 2007, Cancer research.
[17] David J. Freeman,et al. Reinstalling Antitumor Immunity by Inhibiting Tumor-Derived Immunosuppressive Molecule IDO through RNA Interference1 , 2006, The Journal of Immunology.
[18] Stefan Schneeberger,et al. Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells. , 2006, Clinical cancer research : an official journal of the American Association for Cancer Research.
[19] R. Truscott,et al. A fluorescence-based assay for indoleamine 2,3-dioxygenase. , 2006, Analytical biochemistry.
[20] G. Prendergast,et al. Marrying immunotherapy with chemotherapy: why say IDO? , 2005, Cancer research.
[21] Álvaro González,et al. Tryptophan metabolites interfere with the Ehrlich reaction used for the measurement of kynurenine. , 2005, Analytical biochemistry.
[22] M. Lhermitte,et al. Simultaneous determination of tryptophan and kynurenine in serum by HPLC with UV and fluorescence detection. , 2004, Biomedical chromatography : BMC.
[23] M. Parker,et al. Optimised expression and purification of recombinant human indoleamine 2,3-dioxygenase. , 2004, Protein expression and purification.
[24] C. Uyttenhove,et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase , 2003, Nature Medicine.
[25] T. Stone,et al. Endogenous kynurenines as targets for drug discovery and development , 2002, Nature Reviews Drug Discovery.
[26] D. Fuchs,et al. Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer , 2002, British Journal of Cancer.
[27] D. Fuchs,et al. More rapid method for simultaneous measurement of tryptophan and kynurenine by HPLC. , 2002, Clinical chemistry.
[28] D. Fuchs,et al. Increased neopterin production and tryptophan degradation in advanced Parkinson's disease , 2002, Journal of Neural Transmission.
[29] D. Fuchs,et al. Tryptophan degradation and immune activation in Alzheimer's disease , 2000, Journal of Neural Transmission.
[30] U. Haupts,et al. Homogeneous fluorescence readouts for miniaturized high-throughput screening: theory and practice. , 1999, Drug discovery today.
[31] Thomas D. Y. Chung,et al. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays , 1999, Journal of biomolecular screening.
[32] J. Dawson,et al. Heme-Containing Oxygenases. , 1996, Chemical reviews.
[33] M. Sono. Spectroscopic and equilibrium studies of ligand and organic substrate binding to indolamine 2,3-dioxygenase. , 1990, Biochemistry.
[34] O. Takikawa,et al. Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity. , 1988, The Journal of biological chemistry.
[35] C. I. Pogson,et al. Indoleamine 2,3-dioxygenase. A new, rapid, sensitive radiometric assay and its application to the study of the enzyme in rat tissues. , 1980, The Biochemical journal.
[36] C. E. Dalgliesh. 29. The synthesis of N′-formyl-DL-kynurenine, Nα-acetyl-DL-kynurenine and related compounds, and observations on the synthesis of kynurenine , 1952 .