Phenol coefficients and the Ferguson principle.

It is shown that the thermodynamic activity at which many phenols produce an equal degree of antibacterial action is approximately the same. The thermodynamic activity of a dissolved phenol can be expressed in terms of the per cent saturation by setting the saturates solution as the standard state of reference. Thus it is demonstrated that the equitoxic solutions of different phenols are those in which the thermodynamic activity or the per cent saturation and not the actual concentrations are the same. It is shown that, as expected, the reported phenol coefficients of 23 different phenols examined are approximately the same as the ratios between the solubility of the unknown disinfectant and the solubility of phenol and that the deviations are interpretable.

[1]  L. Hammett.  Introduction to the study of physical chemistry , 1952 .

[2]  J. Vincent,et al.  The bacteriostatic action of phenol, benzoic acid and related compounds on Bacterium aerogenes. , 1950, Journal of general microbiology.

[3]  W. G. Murrell,et al.  The esters of 4‐hydroxybenzoic acid and related compounds. IV. The bacteriostatic action of n‐alkyl 4‐hydroxybenzoates , 1950 .

[4]  J. Vincent,et al.  The fungistatic properties of p‐aminobenzoic acid and related compounds. Part II. Relative fungistatic activity , 1949 .

[5]  V. Oettingen,et al.  Phenol and its derivatives : the relation between their chemical constitution and their effect on the organism , 1949 .

[6]  J. Vincent,et al.  Relationship between fungistatic activity and structure in a series of simple aromatic compounds , 1949 .

[7]  J. Ferguson,et al.  The Toxicity of Vapours to the Grain Weevil , 1948 .

[8]  F. Brink,et al.  Thermodynamic analysis of the relative effectiveness of narcotics. , 1948, Journal of cellular and comparative physiology.

[9]  Taylor Es,et al.  The Assimilation of Amino-acids by Bacteria: 2. The Action of Tyrocidin and some Detergent Substances in Releasing Amino-acids from the Internal Environment of Streptococcus faecalis , 1947 .

[10]  J. Porter,et al.  Bacterial Chemistry and Physiology. , 1948 .

[11]  H. C. Marks,et al.  Studies on the Mode of Action of Compounds Containing Available Chlorine , 1945, Journal of bacteriology.

[12]  C. Brewer.  Variations in Phenol Coefficient Determinations of Certain Disinfectants. , 1943, American journal of public health and the nation's health.

[13]  C. Suter.  Relationships between the Structure and the Bactericidal Properties of Phenols. , 1941 .

[14]  E. Mcculloch.  Disinfection and sterilization , 1937 .

[15]  H. Brown,et al.  ANTHELMINTIC STUDIES ON ALKYLHYDROXYBENZENES II. ORTHO- AND PARA-N-ALKYLPHENOLS , 1935 .

[16]  F. W. Tilley,et al.  FURTHER INVESTIGATIONS OF THE RELATION BETWEEN THE CHEMICAL CONSTITUTION AND THE GERMICIDAL ACTIVITY OF ALCOHOLS AND PHENOLS , 1927, Journal of bacteriology.