Powering point-of-care diagnostic devices.

Effective and rapid point-of-care (POC) diagnostics have the capability to revolutionize public healthcare both in developed and developing countries. One of the key challenges that is critical to address in developing POC devices is to effectively and sufficiently power them. In developing countries, where the electricity grid is not well established and the use of batteries is not cost-effective, power supplies are the most problematic issue for stand-alone and self-sustained POC devices. In this review, we provide an overview of techniques for powering POC diagnostic devices for use in both developed and developing countries, as well as detailed discussions of recent advancements in POC devices. Then, we discuss next-generation POC diagnostics and their power source strategies.

[1]  Chong H. Ahn,et al.  Institute of Physics Publishing Journal of Micromechanics and Microengineering a Review of Microvalves , 2022 .

[2]  G. Whitesides,et al.  Simple telemedicine for developing regions: camera phones and paper-based microfluidic devices for real-time, off-site diagnosis. , 2008, Analytical chemistry.

[3]  Gregory G. Lewis,et al.  Quantifying analytes in paper-based microfluidic devices without using external electronic readers. , 2012, Angewandte Chemie.

[4]  Hongying Zhu,et al.  Optical imaging techniques for point-of-care diagnostics. , 2013, Lab on a chip.

[5]  G. Whitesides,et al.  Three-dimensional microfluidic devices fabricated in layered paper and tape , 2008, Proceedings of the National Academy of Sciences.

[6]  Darash Desai,et al.  Tackling HIV through robust diagnostics in the developing world: current status and future opportunities. , 2011, Lab on a chip.

[7]  Manjima Dhar,et al.  Research highlights: microfluidic point-of-care diagnostics , 2014 .

[8]  Xulin Lu,et al.  Biofuel cell-based self-powered biogenerators for online continuous monitoring of neurochemicals in rat brain. , 2013, The Analyst.

[9]  Mohammadali Safavieh,et al.  A simple cassette as point-of-care diagnostic device for naked-eye colorimetric bacteria detection. , 2014, The Analyst.

[10]  Seokheun Choi,et al.  Microscale microbial fuel cells: Advances and challenges. , 2015, Biosensors & bioelectronics.

[11]  Scott T. Phillips,et al.  "Fluidic batteries" as low-cost sources of power in paper-based microfluidic devices. , 2012, Lab on a chip.

[12]  Simon Song,et al.  Flow characterization of electroconvective micromixer with a nanoporous polymer membrane in-situ fabricated using a laser polymerization technique. , 2015, Biomicrofluidics.

[13]  Ebrahim Ghafar-Zadeh,et al.  Wireless Integrated Biosensors for Point-of-Care Diagnostic Applications , 2015, Sensors.

[14]  R. O'Kennedy,et al.  Point-of-care diagnostics, a major opportunity for change in traditional diagnostic approaches: potential and limitations , 2014, Expert review of molecular diagnostics.

[15]  D. Beebe,et al.  The present and future role of microfluidics in biomedical research , 2014, Nature.

[16]  Drew A. Hall,et al.  Efficient power harvesting from the mobile phone audio jack for mHealth peripherals , 2015, 2015 IEEE Global Humanitarian Technology Conference (GHTC).

[17]  Emanuel Carrilho,et al.  Paper-based ELISA. , 2010, Angewandte Chemie.

[18]  J R Buser,et al.  Electromechanical cell lysis using a portable audio device: enabling challenging sample preparation at the point-of-care. , 2015, Lab on a chip.

[19]  Daniel Filippini,et al.  Biosensing with cell phones. , 2014, Trends in biotechnology.

[20]  Shaojun Dong,et al.  Self-powered sensor for trace Hg2+ detection. , 2011, Analytical chemistry.

[21]  Zhong Lin Wang,et al.  Nanotechnology-enabled energy harvesting for self-powered micro-/nanosystems. , 2012, Angewandte Chemie.

[22]  Songjing Li,et al.  An Electromagnetic Microvalve for Pneumatic Control of Microfluidic Systems , 2014, Journal of laboratory automation.

[23]  Seokheun Choi,et al.  Bacteria-powered battery on paper. , 2014, Physical chemistry chemical physics : PCCP.

[24]  J Olivo,et al.  Energy Harvesting and Remote Powering for Implantable Biosensors , 2011, IEEE Sensors Journal.

[25]  C. Ahn,et al.  A new on-chip whole blood/plasma separator driven by asymmetric capillary forces. , 2013, Lab on a chip.

[26]  Seokheun Choi,et al.  An origami paper-based bacteria-powered battery , 2015 .

[27]  Jaewon Lee,et al.  Lab on a chip for in situ diagnosis: From blood to point of care , 2013, Biomedical Engineering Letters.

[28]  David Huckle,et al.  The impact of new trends in POCTs for companion diagnostics, non-invasive testing and molecular diagnostics , 2015, Expert review of molecular diagnostics.

[29]  Emmanuel Delamarche,et al.  Lab-on-a-chip devices , 2015 .

[30]  Francisco Perdigones,et al.  Low consumption single-use microvalve for microfluidic PCB-based platforms , 2014 .

[31]  David Girbau,et al.  Solar-Powered Wireless Temperature Sensor Based on UWB RFID With Self-Calibration , 2015, IEEE Sensors Journal.

[32]  Kristen L. Helton,et al.  Microfluidic Overview of Global Health Issues Microfluidic Diagnostic Technologies for Global Public Health , 2006 .

[33]  J. Justin Gooding,et al.  Recent Advances in Paper-Based Sensors , 2012, Sensors.

[34]  Stephen A. Boppart,et al.  Point-of-care and point-of-procedure optical imaging technologies for primary care and global health , 2014, Science Translational Medicine.

[35]  Luke P. Lee,et al.  Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS). , 2011, Lab on a chip.

[36]  Samuel K Sia,et al.  Commercialization of microfluidic point-of-care diagnostic devices. , 2012, Lab on a chip.

[37]  A StJohn,et al.  Existing and Emerging Technologies for Point-of-Care Testing. , 2014 .

[38]  Scott T. Phillips,et al.  Advances in materials that enable quantitative point-of-care assays , 2013 .

[39]  Hsisheng Teng,et al.  Cyclic Ammonium-Based Ionic Liquids as Potential Electrolytes for Dye-Sensitized Solar Cells , 2012, International Journal of Electrochemical Science.

[40]  Subash C B Gopinath,et al.  Bacterial detection: from microscope to smartphone. , 2014, Biosensors & bioelectronics.

[41]  G. Abel Current status and future prospects of point-of-care testing around the globe , 2015, Expert review of molecular diagnostics.

[42]  W. Russ Algar,et al.  Toward point-of-care diagnostics with consumer electronic devices: the expanding role of nanoparticles , 2015 .

[43]  M C Emre Simsekler,et al.  The regulation of mobile medical applications. , 2014, Lab on a chip.

[44]  Liyun Guan,et al.  Barcode-like paper sensor for smartphone diagnostics: an application of blood typing. , 2014, Analytical chemistry.

[45]  Jungyul Park,et al.  Non-equilibrium electrokinetic micromixer with 3D nanochannel networks. , 2015, Lab on a chip.

[46]  Derek Tseng,et al.  Lensfree microscopy on a cellphone. , 2010, Lab on a chip.

[47]  Josip Car,et al.  Managing immune diseases in the smartphone era: how have apps impacted disease management and their future? , 2015, Expert review of clinical immunology.

[48]  Jaclyn A. Adkins,et al.  Recent developments in paper-based microfluidic devices. , 2015, Analytical chemistry.

[49]  Tassaneewan Laksanasopin,et al.  Low-Cost Microdevices for Point-of-Care Testing , 2013 .

[50]  Y. Gianchandani,et al.  A Microvalve With Integrated Sensors and Customizable Normal State for Low-Temperature Operation , 2009, Journal of Microelectromechanical Systems.

[51]  Youli Zu,et al.  Multiplexed volumetric bar-chart chip for point-of-care diagnostics , 2012, Nature Communications.

[52]  Li Shen,et al.  Point-of-care colorimetric detection with a smartphone. , 2012, Lab on a chip.

[53]  S. Dong,et al.  A self-powered acetaldehyde sensor based on biofuel cell. , 2012, Analytical chemistry.

[54]  Andrew Ustianowski,et al.  Tropical infectious diseases: Diagnostics for the developing world , 2004, Nature Reviews Microbiology.

[55]  Hongying Zhu,et al.  Wide-field fluorescent microscopy on a cell-phone , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[56]  Elisa Michelini,et al.  A 3D-printed device for a smartphone-based chemiluminescence biosensor for lactate in oral fluid and sweat. , 2014, The Analyst.

[57]  Peng Shi,et al.  Photoresponsive microvalve for remote actuation and flow control in microfluidic devices. , 2015, Biomicrofluidics.

[58]  A. Woolley,et al.  Advances in microfluidic materials, functions, integration, and applications. , 2013, Chemical reviews.

[59]  David E. Williams,et al.  Point of care diagnostics: status and future. , 2012, Analytical chemistry.

[60]  Seokheun Choi,et al.  Paper-based batteries: a review. , 2014, Biosensors & bioelectronics.

[61]  Tu San Park,et al.  Rapid and reagentless detection of microbial contamination within meat utilizing a smartphone-based biosensor , 2014, Scientific Reports.

[62]  Mirza Mansoor Baig,et al.  Mobile healthcare applications: system design review, critical issues and challenges , 2014, Australasian Physical & Engineering Sciences in Medicine.

[63]  C. Van Hoof,et al.  Micropower energy harvesting , 2009, ESSDERC 2009.

[64]  Ming-Chun Huang,et al.  Rapid electrochemical detection on a mobile phone. , 2013, Lab on a chip.

[65]  Seokheun Choi,et al.  A micro-sized bio-solar cell for self-sustaining power generation. , 2015, Lab on a chip.

[66]  Mauro Serpelloni,et al.  Passive and Self-Powered Autonomous Sensors for Remote Measurements , 2009, Sensors.

[67]  Eric C. Larson,et al.  SpiroSmart: using a microphone to measure lung function on a mobile phone , 2012, UbiComp.

[68]  B Veigas,et al.  A low cost, safe, disposable, rapid and self-sustainable paper-based platform for diagnostic testing: lab-on-paper , 2014, Nanotechnology.

[69]  Upkar Varshney,et al.  Mobile health: Four emerging themes of research , 2014, Decis. Support Syst..

[70]  Laura Sola,et al.  A fast and simple label-free immunoassay based on a smartphone. , 2014, Biosensors & bioelectronics.

[71]  Sara Tombelli,et al.  Biosensors for biomarkers in medical diagnostics , 2008 .

[72]  N. Engel,et al.  Point-of-Care Testing for Infectious Diseases: Diversity, Complexity, and Barriers in Low- And Middle-Income Countries , 2012, PLoS medicine.

[73]  Ruth McNerney,et al.  Diagnostics for Developing Countries , 2015, Diagnostics.

[74]  Vladimir Leonov,et al.  Thermoelectric Energy Harvesting of Human Body Heat for Wearable Sensors , 2013, IEEE Sensors Journal.

[75]  Tony Jun Huang,et al.  Microfluidic diagnostics for the developing world. , 2012, Lab on a chip.

[76]  Haluk Beyenal,et al.  Wireless sensors powered by microbial fuel cells. , 2005, Environmental science & technology.

[77]  P. Kenis,et al.  Control of pressure-driven components in integrated microfluidic devices using an on-chip electrostatic microvalve , 2014 .

[78]  Seokheun Choi,et al.  Microfluidic-based biosensors toward point-of-care detection of nucleic acids and proteins , 2010, Microfluidics and nanofluidics.

[79]  Marya Lieberman,et al.  Paper analytical devices for fast field screening of beta lactam antibiotics and antituberculosis pharmaceuticals. , 2013, Analytical chemistry.

[80]  Sandeep Kumar Vashist,et al.  Commercial Smartphone-Based Devices and Smart Applications for Personalized Healthcare Monitoring and Management , 2014, Diagnostics.

[81]  Scott T. Phillips,et al.  Two general designs for fluidic batteries in paper-based microfluidic devices that provide predictable and tunable sources of power for on-chip assays , 2013 .

[82]  Shenguang Ge,et al.  A three-dimensional origami-based immuno-biofuel cell for self-powered, low-cost, and sensitive point-of-care testing. , 2014, Chemical communications.

[83]  Lin Wang,et al.  Advances in Smartphone-Based Point-of-Care Diagnostics , 2015, Proceedings of the IEEE.

[84]  Rebecca Schnall,et al.  Review and analysis of existing mobile phone applications for health care-associated infection prevention. , 2015, American journal of infection control.

[85]  Samuel K Sia,et al.  Actuation of elastomeric microvalves in point-of-care settings using handheld, battery-powered instrumentation. , 2010, Lab on a chip.

[86]  Ben Feldman,et al.  Miniature amperometric self-powered continuous glucose sensor with linear response. , 2012, Analytical chemistry.

[87]  Elain Fu,et al.  Progress in the development of paper-based diagnostics for low-resource point-of-care settings. , 2013, Bioanalysis.

[88]  Alejandro Criado,et al.  Inside Cover: [16]Cloverphene: a Clover‐Shaped cata‐Condensed Nanographene with Sixteen Fused Benzene Rings (Angew. Chem. Int. Ed. 1/2012) , 2012 .

[89]  Ryo Yamamoto,et al.  Stand-alone micro fluidic system using partly disposable PDMS microwell array for high throughput cell analysis , 2011, 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference.

[90]  K. Sin,et al.  Evidence-based point-of-care diagnostics: current status and emerging technologies. , 2013, Annual review of analytical chemistry.

[91]  P Neužil,et al.  From chip-in-a-lab to lab-on-a-chip: towards a single handheld electronic system for multiple application-specific lab-on-a-chip (ASLOC). , 2014, Lab on a chip.

[92]  Alex Nemiroski,et al.  Universal mobile electrochemical detector designed for use in resource-limited applications , 2014, Proceedings of the National Academy of Sciences.

[93]  Jin-Woo Choi,et al.  Disposable smart lab on a chip for point-of-care clinical diagnostics , 2004, Proceedings of the IEEE.

[94]  Á. Ríos,et al.  Miniaturization through lab-on-a-chip: utopia or reality for routine laboratories? A review. , 2012, Analytica chimica acta.

[95]  Yun Zhang,et al.  Timing readout in paper device for quantitative point-of-use hemin/G-quadruplex DNAzyme-based bioassays. , 2015, Biosensors & bioelectronics.

[96]  Charles S Henry,et al.  Simple, distance-based measurement for paper analytical devices. , 2013, Lab on a chip.

[97]  Feng Xu,et al.  Paper-based sample-to-answer molecular diagnostic platform for point-of-care diagnostics. , 2015, Biosensors & bioelectronics.

[98]  Jinghua Yu,et al.  A dual functional analytical device for self-powered point of care testing and electric energy storage. , 2015, Chemical communications.

[99]  Deukhyoun Heo,et al.  Batteryless, wireless sensor powered by a sediment microbial fuel cell. , 2008, Environmental science & technology.

[100]  L. Gervais,et al.  Toward one-step point-of-care immunodiagnostics using capillary-driven microfluidics and PDMS substrates. , 2009, Lab on a chip.

[101]  Steve Feng,et al.  Cellphone-Based Hand-Held Microplate Reader for Point-of-Care Testing of Enzyme-Linked Immunosorbent Assays. , 2015, ACS nano.

[102]  Aydogan Ozcan,et al.  Handheld high-throughput plasmonic biosensor using computational on-chip imaging , 2014, Light: Science & Applications.

[103]  Aaron R Wheeler,et al.  Electrochemistry, biosensors and microfluidics: a convergence of fields. , 2015, Chemical Society reviews.

[104]  Aydogan Ozcan,et al.  Integrated rapid-diagnostic-test reader platform on a cellphone. , 2012, Lab on a chip.

[105]  Shelley D Minteer,et al.  Inhibition and activation of glucose oxidase bioanodes for use in a self-powered EDTA sensor. , 2011, Analytical chemistry.

[106]  Zhihua Feng,et al.  Piezoelectric micropump using dual-frequency drive , 2015 .

[107]  Francoise F Giguel,et al.  Micro-a-fluidics ELISA for Rapid CD4 Cell Count at the Point-of-Care , 2014, Scientific Reports.

[108]  Adrienne R. Minerick,et al.  Electrochemical detection techniques in micro- and nanofluidic devices , 2014 .

[109]  Zhong Lin Wang,et al.  Triboelectric nanogenerator built inside clothes for self-powered glucose biosensors , 2013 .

[110]  Peter B. Luppa,et al.  Point-of-care testing (POCT): Current techniques and future perspectives , 2011, TrAC Trends in Analytical Chemistry.

[111]  Da Xing,et al.  A handheld flow genetic analysis system (FGAS): towards rapid, sensitive, quantitative and multiplex molecular diagnosis at the point-of-care level. , 2015, Lab on a chip.

[112]  George M Whitesides,et al.  From the bench to the field in low-cost diagnostics: two case studies. , 2015, Angewandte Chemie.

[113]  Anja Boisen,et al.  Integrating electrochemical detection with centrifugal microfluidics for real-time and fully automated sample testing , 2015 .

[114]  P. Lisowski,et al.  Microfluidic Paper-Based Analytical Devices (μPADs) and Micro Total Analysis Systems (μTAS): Development, Applications and Future Trends , 2013, Chromatographia.

[115]  Bingcheng Lin,et al.  Microvalve-actuated precise control of individual droplets in microfluidic devices. , 2009, Lab on a chip.

[116]  J. Audet,et al.  Current techniques for single-cell lysis , 2008, Journal of The Royal Society Interface.

[117]  Jin-Woo Choi,et al.  Point-of-care testing (POCT) diagnostic systems using microfluidic lab-on-a-chip technologies , 2015 .

[118]  Vladimir Leonov,et al.  A batch process micromachined thermoelectric energy harvester: fabrication and characterization , 2010 .

[119]  Zhong Lin Wang,et al.  Triboelectric nanogenerator as self-powered active sensors for detecting liquid/gaseous water/ethanol , 2013 .

[120]  M. Shafii,et al.  A novel revolving piston minipump , 2015 .

[121]  G. Whitesides,et al.  Diagnostics for the developing world: microfluidic paper-based analytical devices. , 2010, Analytical chemistry.

[122]  Fei Li,et al.  Advances in paper-based point-of-care diagnostics. , 2014, Biosensors & bioelectronics.

[123]  Nam-Trung Nguyen,et al.  MEMS-Micropumps: A Review , 2002 .

[124]  Joseph C Liao,et al.  Advances and challenges in biosensor-based diagnosis of infectious diseases , 2014, Expert review of molecular diagnostics.

[125]  Antonio Luque,et al.  Highly Integrable Pressurized Microvalve for Portable SU-8 Microfluidic Platforms , 2014, Journal of Microelectromechanical Systems.

[126]  Albrecht Brandenburg,et al.  Biochip readout system for point-of-care applications , 2009 .

[127]  A. Hierlemann,et al.  On-chip lysis of mammalian cells through a handheld corona device. , 2015, Lab on a chip.

[128]  Nuno M Reis,et al.  Portable smartphone quantitation of prostate specific antigen (PSA) in a fluoropolymer microfluidic device. , 2015, Biosensors & bioelectronics.

[129]  Alberto J. Palma,et al.  Recent developments in handheld and portable optosensing-a review. , 2011, Analytica chimica acta.

[130]  Aydogan Ozcan,et al.  Cellphone-based devices for bioanalytical sciences , 2014, Analytical and Bioanalytical Chemistry.

[131]  P Kozma,et al.  A novel handheld fluorescent microarray reader for point-of-care diagnostic. , 2013, Biosensors & bioelectronics.

[132]  Jessica Melin,et al.  Microfluidic large-scale integration: the evolution of design rules for biological automation. , 2007, Annual review of biophysics and biomolecular structure.

[133]  Luke P. Lee,et al.  Correction: A Handheld Point-of-Care Genomic Diagnostic System , 2013, PLoS ONE.

[134]  Lin Li,et al.  A smartphone controlled handheld microfluidic liquid handling system. , 2014, Lab on a chip.

[135]  Anthony P F Turner,et al.  Biosensors: sense and sensibility. , 2013, Chemical Society reviews.

[136]  Loreto Mateu,et al.  Review of energy harvesting techniques and applications for microelectronics (Keynote Address) , 2005, SPIE Microtechnologies.

[137]  S. Ng,et al.  Plug-and-play microvalve and micropump for rapid integration with microfluidic chips , 2015 .

[138]  S Elizabeth Hulme,et al.  Incorporation of prefabricated screw, pneumatic, and solenoid valves into microfluidic devices. , 2009, Lab on a chip.

[139]  M. Jönsson‐Niedziółka,et al.  Self-powered biosensor for ascorbic acid with a Prussian blue electrochromic display. , 2014, Biosensors & bioelectronics.

[140]  Andrés Felipe Sandoval Cruz,et al.  A low-cost miniaturized potentiostat for point-of-care diagnosis. , 2014, Biosensors & bioelectronics.