Halofuginone enhances the radiation sensitivity of human tumor cell lines.

[1]  Jonathan Maybaum,et al.  Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells , 2009, Molecular Cancer Therapeutics.

[2]  J. Massagué,et al.  TGFβ in Cancer , 2008, Cell.

[3]  M. Anscher,et al.  Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury. , 2008, International journal of radiation oncology, biology, physics.

[4]  M. Pines.  Targeting TGFβ signaling to inhibit fibroblast activation as a therapy for fibrosis and cancer: effect of halofuginone , 2008, Expert opinion on drug discovery.

[5]  J. Nickoloff,et al.  Regulation of DNA double-strand break repair pathway choice , 2008, Cell Research.

[6]  W. Plunkett,et al.  H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation , 2007, Molecular Cancer Therapeutics.

[7]  M. Barcellos-Hoff,et al.  New rationales for using TGFbeta inhibitors in radiotherapy , 2007, International journal of radiation biology.

[8]  Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. , 2006, Cancer research.

[9]  D. Lacombe,et al.  Phase I and pharmacokinetic study of halofuginone, an oral quinazolinone derivative in patients with advanced solid tumours. , 2006, European journal of cancer.

[10]  B. Teicher,et al.  Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation. , 2006, International journal of radiation oncology, biology, physics.

[11]  V. Natale,et al.  H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[12]  I. Bièche,et al.  Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition. , 2006, Neoplasia.

[13]  P. Harari,et al.  Radiation combined with EGFR signal inhibitors: head and neck cancer focus. , 2006, Seminars in radiation oncology.

[14]  P. Harari,et al.  Radiation and new molecular agents, part II: targeting HDAC, HSP90, IGF-1R, PI3K, and Ras. , 2006, Seminars in radiation oncology.

[15]  A. Nagler,et al.  Halofuginone inhibits angiogenesis and growth in implanted metastatic rat brain tumor model--an MRI study. , 2004, Neoplasia.

[16]  A. Nagler,et al.  Suppression of hepatocellular carcinoma growth in mice by the alkaloid coccidiostat halofuginone. , 2004, European journal of cancer.

[17]  James B. Mitchell,et al.  Amelioration of Radiation-induced Fibrosis , 2004, Journal of Biological Chemistry.

[18]  Y. Ogawa,et al.  Histopathologic amelioration of fibroproliferative change in rat irradiated lung using soluble transforming growth factor-beta (TGF-beta) receptor mediated by adenoviral vector. , 2004, International journal of radiation oncology, biology, physics.

[19]  J. Thacker,et al.  The mammalian XRCC genes: their roles in DNA repair and genetic stability. , 2003, DNA repair.

[20]  S. Dupont,et al.  Links between Tumor Suppressors p53 Is Required for TGF-β Gene Responses by Cooperating with Smads , 2003, Cell.

[21]  T. Samulski,et al.  Soluble TGFbeta type II receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats. , 2002, International journal of radiation oncology, biology, physics.

[22]  A. Nagler,et al.  Growth inhibition of prostate cancer xenografts by halofuginone * † , 2002, The Prostate.

[23]  Ruihua Chen,et al.  Blockade of the effects of TGF-beta1 on mesangial cells by overexpression of Smad7. , 2002, Journal of the American Society of Nephrology : JASN.

[24]  T. McGaha,et al.  Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts. , 2002, The Journal of investigative dermatology.

[25]  James B. Mitchell,et al.  Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. , 2002, The American journal of pathology.

[26]  Junjie Chen,et al.  Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress* , 2001, The Journal of Biological Chemistry.

[27]  A. Nagler,et al.  Halofuginone: a potent inhibitor of critical steps in angiogenesis progression , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[28]  V. Yamazaki,et al.  A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage , 2000, Current Biology.

[29]  M. Neeman,et al.  Inhibition of neovascularization and tumor growth, and facilitation of wound repair, by halofuginone, an inhibitor of collagen type I synthesis. , 1999, Neoplasia.

[30]  M. Pines,et al.  Halofuginone: a novel antifibrotic therapy. , 1998, General pharmacology.

[31]  Keunchil Park,et al.  Expression of Transforming Growth Factor β Type II Receptor Reduces Tumorigenicity in Human Gastric Cancer Cells , 1997 .

[32]  Y. Bang,et al.  Expression of transforming growth factor beta type II receptor reduces tumorigenicity in human gastric cancer cells. , 1997, Cancer research.

[33]  M. Anscher,et al.  Normal tissue injury after cancer therapy is a local response exacerbated by an endocrine effect of TGFβ , 1995 .

[34]  M. Anscher,et al.  Short communication: normal tissue injury after cancer therapy is a local response exacerbated by an endocrine effect of TGF beta. , 1995, The British journal of radiology.

[35]  J. Mitchell,et al.  In vitro studies of Taxol as a radiation sensitizer in human tumor cells. , 1994, Journal of the National Cancer Institute.

[36]  O. Halevy,et al.  Halofuginone: an inhibitor of collagen type I synthesis. , 1993, Biochimica et biophysica acta.

[37]  M. Anscher,et al.  Transforming growth factor-beta 1 expression in irradiated liver. , 1990, Radiation research.

[38]  M. Anscher,et al.  Transforming growth factor-beta 1 expression in irradiated liver. , 1990, Radiation research.