Evaluation of poly(lactic acid) as a biodegradable drug delivery system for parenteral administration

Abstract Poly(lactic acid) (PLA) microspheres of 1–10 μm diameter prepared by emulsion deposition and containing entrapped prednisolone released the drug rapidly into an aqueous medium. Similarly sized microparticles prepared by a fusion process exhibited a more prolonged drug release profile and may have potential as a long-acting parenteral delivery system. Both methods of fabricating the polymer produced material which was cytotoxic when phagocytosed by mouse peritoneal macrophages. The intracellular toxicity and hence potential irritancy in vivo was only partially overcome by incorporating anti-inflammatory drug. Compressed implants of the same polymers containing prednisolone 10% w/w (100 mg·cm −3 ) and weighing 12 mg were readily administered and sustained the delivery of the drug for over 30 days without complications at the implantation site.

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