A Million Cancer Genome Warehouse

Abstract : This white paper discusses the motivation and issues surrounding the development of a repository and associated computational infrastructure to house and process a million genomes to help battle cancer, which we call the Million Cancer Genome Warehouse. It is proposed as an example of an information commons and a computing system that will bring about precision medicine, coupling established clinical pathological indexes with state-of-the-art molecular profiling to create diagnostic, prognostic, and therapeutic strategies precisely tailored to each patient's individual requirements. The goal of the white paper is to stimulate discussion so as to help reach consensus about the need to construct a Million Cancer Genome Warehouse and what its nature should be. To try to anticipate concerns, including thorough cost estimates, it covers topics as varied as high-level health policy issues to low-level details about statistical analysis, data formats and structures, software design, and hardware construction and cost.

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