Engineering of radiolabeled iron oxide nanoparticles for dual-modality imaging.

Over the last decade, radiolabeled iron oxide nanoparticles have been developed as promising contrast agents for dual-modality positron emission tomography/magnetic resonance imaging (PET/MRI) or single-photon emission computed tomography/magnetic resonance imaging (SPECT/MRI). The combination of PET (or SPECT) with MRI can offer synergistic advantages for noninvasive, sensitive, high-resolution, and quantitative imaging, which is suitable for early detection of various diseases such as cancer. Here, we summarize the recent advances on radiolabeled iron oxide nanoparticles for dual-modality imaging, through the use of a variety of PET (and SPECT) isotopes by using both chelator-based and chelator-free radiolabeling techniques. WIREs Nanomed Nanobiotechnol 2016, 8:619-630. doi: 10.1002/wnan.1386.

[1]  R. Birdwell.  Molecular Imaging: The Vision and Opportunity for Radiology in the Future , 2008 .

[2]  Weibo Cai,et al.  Nanoplatforms for targeted molecular imaging in living subjects. , 2007, Small.

[3]  T. Hyeon,et al.  Chemical design of biocompatible iron oxide nanoparticles for medical applications. , 2013, Small.

[4]  A. Arabzadeh,et al.  Magnetic resonance contrast media sensing in vivo molecular imaging agents: an overview. , 2011, Current radiopharmaceuticals.

[5]  P. Aspelin,et al.  Multimodality imaging using SPECT/CT and MRI and ligand functionalized 99mTc-labeled magnetic microbubbles , 2013, EJNMMI Research.

[6]  Hao Hong,et al.  Chelator-free synthesis of a dual-modality PET/MRI agent. , 2013, Angewandte Chemie.

[7]  Seulki Lee,et al.  Activatable molecular probes for cancer imaging. , 2010, Current topics in medicinal chemistry.

[8]  Lu Zhang,et al.  MRI/SPECT/Fluorescent Tri‐Modal Probe for Evaluating the Homing and Therapeutic Efficacy of Transplanted Mesenchymal Stem Cells in a Rat Ischemic Stroke Model , 2015, Advanced functional materials.

[9]  George Loudos,et al.  (99m)Tc-labeled aminosilane-coated iron oxide nanoparticles for molecular imaging of ανβ3-mediated tumor expression and feasibility for hyperthermia treatment. , 2014, Journal of colloid and interface science.

[10]  Weibo Cai,et al.  Iron oxide decorated MoS2 nanosheets with double PEGylation for chelator-free radiolabeling and multimodal imaging guided photothermal therapy. , 2015, ACS nano.

[11]  Taeghwan Hyeon,et al.  Large-scale synthesis of uniform and extremely small-sized iron oxide nanoparticles for high-resolution T1 magnetic resonance imaging contrast agents. , 2011, Journal of the American Chemical Society.

[12]  Andrea Protti,et al.  (⁹⁹m)Tc-bisphosphonate-iron oxide nanoparticle conjugates for dual-modality biomedical imaging. , 2011, Bioconjugate chemistry.

[13]  Karthikeyan Subramani,et al.  Magnetic resonance imaging tracking of stem cells in vivo using iron oxide nanoparticles as a tool for the advancement of clinical regenerative medicine. , 2011, Chemical reviews.

[14]  J. Vercher-Conejero,et al.  Clinical oncologic applications of PET/MRI: a new horizon. , 2014, American journal of nuclear medicine and molecular imaging.

[15]  Arutselvan Natarajan,et al.  Thermal dosimetry predictive of efficacy of 111In-ChL6 nanoparticle AMF--induced thermoablative therapy for human breast cancer in mice. , 2007, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[16]  Linda Knutsson,et al.  99mTc-Labeled Superparamagnetic Iron Oxide Nanoparticles for Multimodality SPECT/MRI of Sentinel Lymph Nodes , 2012, The Journal of Nuclear Medicine.

[17]  M. Meyerand,et al.  Intrinsically Germanium‐69‐Labeled Iron Oxide Nanoparticles: Synthesis and In‐Vivo Dual‐Modality PET/MR Imaging , 2014, Advanced materials.

[18]  C. Robic,et al.  Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. , 2008, Chemical reviews.

[19]  Taeghwan Hyeon,et al.  Chemical synthesis and assembly of uniformly sized iron oxide nanoparticles for medical applications. , 2015, Accounts of chemical research.

[20]  Hui Tan,et al.  Design and preliminary assessment of 99mTc-labeled ultrasmall superparamagnetic iron oxide-conjugated bevacizumab for single photon emission computed tomography/magnetic resonance imaging of hepatocellular carcinoma , 2014, Journal of Radioanalytical and Nuclear Chemistry.

[21]  G. Delso,et al.  PET/MRI system design , 2009, European Journal of Nuclear Medicine and Molecular Imaging.

[22]  Oliver T. Bruns,et al.  A simple and widely applicable method to 59Fe-radiolabel monodisperse superparamagnetic iron oxide nanoparticles for in vivo quantification studies. , 2012, ACS nano.

[23]  Eun Kyoung Ryu,et al.  Hybrid PET/MR imaging of tumors using an oleanolic acid-conjugated nanoparticle. , 2013, Biomaterials.

[24]  Hak Soo Choi,et al.  Design considerations for tumour-targeted nanoparticles. , 2010, Nature nanotechnology.

[25]  Habib Zaidi,et al.  PET versus SPECT: strengths, limitations and challenges , 2008, Nuclear medicine communications.

[26]  S. Choi,et al.  Water-dispersible ferrimagnetic iron oxide nanocubes with extremely high r₂ relaxivity for highly sensitive in vivo MRI of tumors. , 2012, Nano letters.

[27]  Weidong Yang,et al.  From PET/CT to PET/MRI: advances in instrumentation and clinical applications. , 2014, Molecular Pharmaceutics.

[28]  D. Meier,et al.  Development and evaluation of a dual-modality (MRI/SPECT) molecular imaging bioprobe. , 2012, Nanomedicine : nanotechnology, biology, and medicine.

[29]  Alice M. Bowen,et al.  Chelate-free metal ion binding and heat-induced radiolabeling of iron oxide nanoparticles† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc02778g Click here for additional data file. , 2014, Chemical science.

[30]  Ciprian Catana,et al.  Simultaneous PET-MRI: a new approach for functional and morphological imaging , 2008, Nature Medicine.

[31]  Michael J. Welch,et al.  In vivo evaluation of (64)Cu-labeled magnetic nanoparticles as a dual-modality PET/MR imaging agent. , 2010, Bioconjugate chemistry.

[32]  Weibo Cai,et al.  Multimodality Molecular Imaging of Tumor Angiogenesis , 2008, Journal of Nuclear Medicine.

[33]  Taeghwan Hyeon,et al.  Designed synthesis of uniformly sized iron oxide nanoparticles for efficient magnetic resonance imaging contrast agents. , 2012, Chemical Society reviews.

[34]  Heather M. Hennkens,et al.  Radiometals for combined imaging and therapy. , 2013, Chemical reviews.

[35]  R. H. Loeppert,et al.  Arsenite and Arsenate Adsorption on Ferrihydrite: Kinetics, Equilibrium, and Adsorption Envelopes , 1998 .

[36]  U. Haberkorn,et al.  Bifunctional chelators in the design and application of radiopharmaceuticals for oncological diseases. , 2012, Current medicinal chemistry.

[37]  Ick Chan Kwon,et al.  Multifunctional nanoparticles for multimodal imaging and theragnosis. , 2012, Chemical Society reviews.

[38]  S. Cherry,et al.  Application of Silicon Photomultipliers to Positron Emission Tomography , 2011, Annals of Biomedical Engineering.

[39]  Martin S Judenhofer,et al.  Applications for preclinical PET/MRI. , 2013, Seminars in nuclear medicine.

[40]  Jaehong Key,et al.  Nanoparticles for multimodal in vivo imaging in nanomedicine , 2014, International journal of nanomedicine.

[41]  Hao Hong,et al.  Molecular imaging and therapy of cancer with radiolabeled nanoparticles. , 2009, Nano today.

[42]  Yin Zhang,et al.  PET tracers based on Zirconium-89. , 2011, Current radiopharmaceuticals.

[43]  David A Mankoff,et al.  A definition of molecular imaging. , 2007, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[44]  Benjamin R. Jarrett,et al.  Synthesis of 64Cu-labeled magnetic nanoparticles for multimodal imaging. , 2008, Bioconjugate chemistry.

[45]  S. Larson,et al.  89Zr-DFO-J591 for ImmunoPET of Prostate-Specific Membrane Antigen Expression In Vivo , 2010, The Journal of Nuclear Medicine.

[46]  Greg M Thurber,et al.  18F labeled nanoparticles for in vivo PET-CT imaging. , 2009, Bioconjugate chemistry.

[47]  M. Bawendi,et al.  Renal clearance of quantum dots , 2007, Nature Biotechnology.

[48]  Jan Grimm,et al.  Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle , 2014, Nature Communications.

[49]  J. T. Mayo,et al.  Low-Field Magnetic Separation of Monodisperse Fe3O4 Nanocrystals , 2006, Science.

[50]  高明远,et al.  In Situ 111In-doping for Achieving Biocompatible and Non-leachable 111In-labeled Fe3O4 Nanoparticles , 2014 .

[51]  Kavitha Sunassee,et al.  Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging , 2014, Biomaterials.

[52]  James Rieffel,et al.  Recent Advances in Higher-Order, Multimodal, Biomedical Imaging Agents. , 2015, Small.

[53]  Srinivas Sridhar,et al.  Integrity of (111)In-radiolabeled superparamagnetic iron oxide nanoparticles in the mouse. , 2015, Nuclear medicine and biology.

[54]  J. Adán,et al.  In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles , 2014, International journal of nanomedicine.

[55]  Wei Wang,et al.  Carbon-11 radiolabeling of iron-oxide nanoparticles for dual-modality PET/MR imaging. , 2013, Nanoscale.

[56]  René M. Botnar,et al.  Bisphosphonate-Anchored PEGylation and Radiolabeling of Superparamagnetic Iron Oxide: Long-Circulating Nanoparticles for in Vivo Multimodal (T1 MRI-SPECT) Imaging , 2012, ACS nano.

[57]  Kai Liu,et al.  Rapid size-controlled synthesis of dextran-coated, 64Cu-doped iron oxide nanoparticles. , 2012, ACS nano.

[58]  H. Zaidi,et al.  An outlook on future design of hybrid PET/MRI systems. , 2011, Medical physics.

[59]  Zhen Cheng,et al.  Affibody modified and radiolabeled gold-iron oxide hetero-nanostructures for tumor PET, optical and MR imaging. , 2013, Biomaterials.

[60]  N. Menguy,et al.  EXAFS and HRTEM evidence for As(III)-containing surface precipitates on nanocrystalline magnetite: implications for As sequestration. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[61]  Mason B. Tomson,et al.  Effect of magnetite particle size on adsorption and desorption of arsenite and arsenate , 2005 .

[62]  C. Innocenti,et al.  Comparison of the magnetic, radiolabeling, hyperthermic and biodistribution properties of hybrid nanoparticles bearing CoFe2O4 and Fe3O4 metal cores , 2014, Nanotechnology.

[63]  Shuang Liu.  Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides. , 2008, Advanced drug delivery reviews.

[64]  Hao Hong,et al.  cRGD-functionalized, DOX-conjugated, and ⁶⁴Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging. , 2011, Biomaterials.

[65]  Chenjie Xu,et al.  PET/MRI Dual-Modality Tumor Imaging Using Arginine-Glycine-Aspartic (RGD)–Conjugated Radiolabeled Iron Oxide Nanoparticles , 2008, Journal of Nuclear Medicine.

[66]  Young Chun,et al.  Water-dispersible magnetite-reduced graphene oxide composites for arsenic removal. , 2010, ACS nano.

[67]  Weibo Cai,et al.  Positron emission tomography imaging using radiolabeled inorganic nanomaterials. , 2015, Accounts of chemical research.

[68]  Taeghwan Hyeon,et al.  Uniform mesoporous dye-doped silica nanoparticles decorated with multiple magnetite nanocrystals for simultaneous enhanced magnetic resonance imaging, fluorescence imaging, and drug delivery. , 2010, Journal of the American Chemical Society.

[69]  Feng Chen,et al.  Intrinsically radiolabeled nanoparticles: an emerging paradigm. , 2014, Small.

[70]  C. Claussen,et al.  Simultaneous Mr/pet Imaging of the Human Brain: Feasibility Study 1 , 2022 .