INHALATION TOXICITY, NEUROTOXICITY, AND TOXICOKINETIC STUDIES OF p-CHLOROBENZOTRIFLUORIDE

Sprague-Dawley rats (10/sex/group) were exposed via whole-body inhalation exposure 6 h/ day, 5 days/wk for 13 wk, to exposure levels (mean SD) of 0, 10 1, 51 1, or 252 5 ppm of para -chlorobenzotrifluoride (PCBTF, CAS number 98-56-6). Additional animals were included for evaluation after a 13-wk recovery (5/sex/ group), neuropathology (5/sex/group/interval), and for toxicokinetic analyses (45 females, 51 ppm group only). The high exposure level was set based upon results of a 4-wk study, which found tremors, hyperactivity, and increases in total protein, calcium, albumin, globulin, and phosphorus at 1044 ppm, and increases in absolute or relative organ weights in the kidney at 262 ppm and above and in the liver at 494 ppm and above. In the 13-wk study, there were no untoward observations recorded either during the exposures or during weekly detailed clinical evaluations. There was no indication of any PCBTF-related ocular disease or changes seen in any measured hematological and clinical chemistry paramet...