Gastric juice MicroRNAs as potential biomarkers for the screening of gastric cancer

MicroRNAs (miRNAs) play a crucial role in carcinogenesis; however, it largely remains unclear whether miRNAs in gastric juice, which is specific for gastric tissues, can be used as biomarkers for gastric cancer. The objective of the current study was to investigate the feasibility of using gastric juice miRNAs as potential biomarkers to assist in screening for gastric cancer.

[1]  Chin-Wen Chi,et al.  miR-21 microRNA expression in human gastric carcinomas and its clinical association. , 2008, Anticancer research.

[2]  K. Vickers,et al.  Lipid-based carriers of microRNAs and intercellular communication , 2012, Current opinion in lipidology.

[3]  B. Xiao,et al.  Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using piRNAs as markers. , 2010, Clinical biochemistry.

[4]  M. Duffy,et al.  National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for use of tumor markers in liver, bladder, cervical, and gastric cancers. , 2010, Clinical chemistry.

[5]  M. Bissell National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Liver, Bladder, Cervical, and Gastric Cancers , 2011 .

[6]  M. L. Hastings,et al.  Selective Release of MicroRNA Species from Normal and Malignant Mammary Epithelial Cells , 2010, PloS one.

[7]  S. Lowe,et al.  The microcosmos of cancer , 2012, Nature.

[8]  T. Xia,et al.  Gastric juice microRNA-421 is a new biomarker for screening gastric cancer , 2012, Tumor Biology.

[9]  B. Xiao,et al.  Differential expression of microRNA species in human gastric cancer versus non‐tumorous tissues , 2009, Journal of gastroenterology and hepatology.

[10]  Michael Hsiao,et al.  Diagnosis of Gastric Malignancy Using Gastric Juice α1-antitrypsin , 2010, Cancer Epidemiology, Biomarkers & Prevention.

[11]  N. Park,et al.  Salivary microRNA: Discovery, Characterization, and Clinical Utility for Oral Cancer Detection , 2009, Clinical Cancer Research.

[12]  P. Laurén,et al.  THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. , 1965, Acta pathologica et microbiologica Scandinavica.

[13]  Zhen Jiang,et al.  Increased expression of miR-421 in human gastric carcinoma and its clinical association , 2009, Journal of Gastroenterology.

[14]  J. Vandesompele,et al.  MicroRNA expression profiling to identify and validate reference genes for relative quantification in colorectal cancer , 2010, BMC Cancer.

[15]  R. Cui,et al.  The intrinsic fluorescence spectrum of dilute gastric juice as a novel diagnostic tool for gastric cancer , 2011, Journal of digestive diseases.

[16]  Zhenggang Zhu,et al.  Macroscopic Borrmann Type as a Simple Prognostic Indicator in Patients with Advanced Gastric Cancer , 2009, Oncology.

[17]  Japanese Gastric Cancer Association Japanese Classification of Gastric Carcinoma – 2nd English Edition – , 1998, Gastric Cancer.

[18]  X. Chen,et al.  Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases , 2008, Cell Research.

[19]  B. Xiao,et al.  MiR-421 is a functional marker of circulating tumor cells in gastric cancer patients , 2012, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[20]  Xue-mei Ma,et al.  Identification of Suitable Reference Genes for qPCR Analysis of Serum microRNA in Gastric Cancer Patients , 2012, Digestive Diseases and Sciences.

[21]  Jun Yu,et al.  Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps , 2011, Gut.

[22]  G. Calin,et al.  MicroRNAs in body fluids—the mix of hormones and biomarkers , 2011, Nature Reviews Clinical Oncology.

[23]  Jessica A. Weber,et al.  The microRNA spectrum in 12 body fluids. , 2010, Clinical chemistry.

[24]  X. Chen,et al.  Horizontal transfer of microRNAs: molecular mechanisms and clinical applications , 2012, Protein & Cell.

[25]  Rong Huan,et al.  Detection of miR-106a in gastric carcinoma and its clinical significance. , 2009, Clinica chimica acta; international journal of clinical chemistry.

[26]  Yiguo Jiang,et al.  miR-106a-mediated malignant transformation of cells induced by anti-benzo[a]pyrene-trans-7,8-diol-9,10-epoxide. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.

[27]  A. Uchiyama,et al.  Association of microRNA-21 expression with its targets, PDCD4 and TIMP3, in pancreatic ductal adenocarcinoma , 2012, Modern Pathology.

[28]  Wei Zhang,et al.  Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer. , 2012, Cancer letters.

[29]  Xinjun Zhang,et al.  Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker , 2010, Journal of Molecular Medicine.

[30]  Tohru Mochizuki,et al.  Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line , 2010, PloS one.

[31]  W. Wassef,et al.  An update in endoscopic management of gastric cancer , 2011, Current opinion in gastroenterology.

[32]  D. Ichikawa,et al.  Circulating microRNAs in plasma of patients with gastric cancers , 2010, British Journal of Cancer.

[33]  M. Rugge,et al.  Clinical usefulness of gastric-juice analysis in 2007: the stone that the builders rejected has become the cornerstone. , 2007, Gastrointestinal endoscopy.