Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

[1]  T. Mak,et al.  CD28 signals through acidic sphingomyelinase , 1995, The Journal of experimental medicine.

[2]  D. Green,et al.  FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. , 1995, Immunity.

[3]  S. Grant,et al.  Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells. , 1994, The Journal of biological chemistry.

[4]  R. Testi,et al.  Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase , 1994, The Journal of experimental medicine.

[5]  M. Krönke,et al.  Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling , 1994, Cell.

[6]  C. Potten,et al.  Apoptosis and cancer chemotherapy. , 1994, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[7]  A. Haimovitz-Friedman,et al.  Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis , 1994, The Journal of experimental medicine.

[8]  L. Sanz,et al.  Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase. , 1994, The Journal of biological chemistry.

[9]  A. Wittinghofer,et al.  Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides , 1994, Molecular and cellular biology.

[10]  L. Daniel,et al.  1-beta-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells. , 1994, The Journal of biological chemistry.

[11]  P. Baeuerle,et al.  Sphingomyelinase activates proteolytic I kappa B-alpha degradation in a cell-free system. , 1994, The Journal of biological chemistry.

[12]  R. Kolesnick,et al.  The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling , 1994, Cell.

[13]  Y. Hannun,et al.  The sphingomyelin cycle and the second messenger function of ceramide. , 1994, The Journal of biological chemistry.

[14]  R. Kolesnick,et al.  Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase. , 1994, The Journal of biological chemistry.

[15]  S. Grant,et al.  Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[16]  A. Merrill,et al.  Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. , 1993, The Journal of biological chemistry.

[17]  R. Kolesnick,et al.  Substrate recognition by ceramide-activated protein kinase. Evidence that kinase activity is proline-directed. , 1993, The Journal of biological chemistry.

[18]  R. Kolesnick,et al.  Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells. , 1993, The Journal of biological chemistry.

[19]  A. Składanowski,et al.  Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells. , 1993, Biochemical pharmacology.

[20]  R. Dobrowsky,et al.  Ceramide activates heterotrimeric protein phosphatase 2A. , 1993, The Journal of biological chemistry.

[21]  R. Kolesnick,et al.  Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells. , 1993, The Journal of biological chemistry.

[22]  A. Futerman,et al.  Inhibition of sphingolipid synthesis affects axonal outgrowth in cultured hippocampal neurons. , 1993, The Journal of biological chemistry.

[23]  R. Perez-soler,et al.  Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug-resistant cells. , 1993, Cancer research.

[24]  Y. Hannun,et al.  Programmed cell death induced by ceramide. , 1993, Science.

[25]  K. Hirschberg,et al.  The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver. , 1993, The Biochemical journal.

[26]  D. Vaux.  Toward an understanding of the molecular mechanisms of physiological cell death. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[27]  L. Zwelling,et al.  Circumvention of resistance by doxorubicin, but not by idarubicin, in a human leukemia cell line containing an intercalator-resistant form of topoisomerase II: evidence for a non-topoisomerase II-mediated mechanism of doxorubicin cytotoxicity. , 1993, Biochemical pharmacology.

[28]  I. Orlow,et al.  Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta. , 1993, Science.

[29]  S. Spiegel,et al.  Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts. , 1992, The Journal of biological chemistry.

[30]  A. Merrill,et al.  Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme. , 1992, The Journal of nutrition.

[31]  M. D’Incalci,et al.  Apoptosis Biochemical events and relevance to cancer chemotherapy , 1992, FEBS letters.

[32]  W. Bursch,et al.  Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[33]  K. Sandhoff,et al.  Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. , 1992, The Journal of biological chemistry.

[34]  C. Potten,et al.  Abrogation of adriamycin toxicity in vivo by cycloheximide. , 1992, Biochemical pharmacology.

[35]  R. Bell,et al.  Elevated ceramide levels in GH4C1 cells treated with retinoic acid. , 1992, Biochimica et biophysica acta.

[36]  C. Sarraf,et al.  The nature of cytotoxic drug-induced cell death in murine intestinal crypts. , 1992, British Journal of Cancer.

[37]  R. Kolesnick,et al.  Tumor necrosis factor-alpha activates the sphingomyelin signal transduction pathway in a cell-free system. , 1992, Science.

[38]  R. Kolesnick,et al.  Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[39]  A. Merrill,et al.  Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. , 1991, The Journal of biological chemistry.

[40]  R. Epstein,et al.  Drug-induced DNA damage and tumor chemosensitivity. , 1990, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[41]  A. Eastman,et al.  Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. , 1990, Biochemical pharmacology.

[42]  R. Kolesnick,et al.  Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin. , 1990, The Journal of biological chemistry.

[43]  D. D. Jones,et al.  An update of the enzymology and regulation of sphingomyelin metabolism. , 1990, Biochimica et biophysica acta.

[44]  Y. Hannun,et al.  Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. , 1989, The Journal of biological chemistry.

[45]  S. Kaufmann.  Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. , 1989, Cancer research.

[46]  C. Haanen,et al.  Idarubicin v daunorubicin: preclinical and clinical pharmacokinetic studies. , 1989, Seminars in oncology.

[47]  P. Quirke,et al.  Kinetic and Physical Studies of Cell Death Induced By Chemotherapeutic Agents Or Hyperthermia , 1986, Cell and tissue kinetics.

[48]  A. Wyllie,et al.  Macrophage recognition of cells undergoing programmed cell death (apoptosis). , 1985, Immunology.

[49]  P. K. Smith,et al.  Measurement of protein using bicinchoninic acid. , 1985, Analytical biochemistry.

[50]  A. Wyllie.  Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation , 1980, Nature.

[51]  M. M. Bradford.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[52]  J. Kerr,et al.  An electron‐microscope study of the mode of cell death induced by cancer‐chemotherapeutic agents in populations of proliferating normal and neoplastic cells , 1975, The Journal of pathology.

[53]  D. Alberts,et al.  The pharmacokinetics of daunomycin in man , 1971, Clinical pharmacology and therapeutics.

[54]  A. Nowotny.  Microdetermination of Phosphorus , 1979 .

[55]  D. Karnofsky,et al.  Chemotherapy of neoplastic diseases. , 1950, The Medical clinics of North America.