The extracellular matrix at a glance

![Figure][1] The extracellular matrix (ECM) is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue

[1]  E. Hohenester,et al.  Mammalian collagen receptors. , 2007, Matrix biology : journal of the International Society for Matrix Biology.

[2]  R. Gorga,et al.  Nanofibrous composites for tissue engineering applications. , 2009, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[3]  Douglas W DeSimone,et al.  The extracellular matrix in development and morphogenesis: a dynamic view. , 2010, Developmental biology.

[4]  P. Friedl,et al.  Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms , 2009, Cell and Tissue Research.

[5]  D. Jackson Collagens , 1978 .

[6]  R. Tucker,et al.  The regulation of tenascin expression by tissue microenvironments. , 2009, Biochimica et biophysica acta.

[7]  R. Fässler,et al.  The role of integrin binding sites in fibronectin matrix assembly in vivo. , 2008, Current opinion in cell biology.

[8]  Andre Levchenko,et al.  Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs , 2009, Proceedings of the National Academy of Sciences.

[9]  R. Iozzo,et al.  Tumor microenvironment: Modulation by decorin and related molecules harboring leucine‐rich tandem motifs , 2008, International journal of cancer.

[10]  D. Kaplan,et al.  Electrospun silk biomaterial scaffolds for regenerative medicine. , 2009, Advanced drug delivery reviews.

[11]  L. Schaefer,et al.  Proteoglycans: from structural compounds to signaling molecules , 2009, Cell and Tissue Research.

[12]  Tomaz Velnar,et al.  The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms , 2009, The Journal of international medical research.

[13]  Olivier De Wever,et al.  Stromal myofibroblasts are drivers of invasive cancer growth , 2008, International journal of cancer.

[14]  K. Csiszȧr,et al.  Lysyl oxidase in development, aging and pathologies of the skin. , 2005, Pathologie-biologie.

[15]  Matthew J. Paszek,et al.  The Tension Mounts: Mechanics Meets Morphogenesis and Malignancy , 2004, Journal of Mammary Gland Biology and Neoplasia.

[16]  W. Friess,et al.  Collagen--biomaterial for drug delivery. , 1998, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[17]  Kenneth M. Yamada,et al.  Fibronectin at a glance , 2002, Journal of Cell Science.

[18]  M J Bissell,et al.  Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. , 1996, Physiological reviews.

[19]  Adam Byron,et al.  Integrin ligands at a glance , 2006, Journal of Cell Science.

[20]  Antonio Giordano,et al.  Smart materials as scaffolds for tissue engineering , 2005, Journal of cellular physiology.

[21]  J. Campisi,et al.  Inflammatory networks during cellular senescence: causes and consequences. , 2010, Trends in molecular medicine.

[22]  H. Kleinman,et al.  Matrigel: basement membrane matrix with biological activity. , 2005, Seminars in cancer biology.

[23]  Stephen F Badylak,et al.  The extracellular matrix as a biologic scaffold material. , 2007, Biomaterials.

[24]  Valerie M. Weaver,et al.  A tense situation: forcing tumour progression , 2009, Nature Reviews Cancer.

[25]  Andrew M. Smith,et al.  Designing peptide based nanomaterials. , 2008, Chemical Society reviews.

[26]  A. Friedl Proteoglycans: master modulators of paracrine fibroblast-carcinoma cell interactions. , 2010, Seminars in cell & developmental biology.

[27]  Brigitte Angres,et al.  Cell adhesion profiling using extracellular matrix protein microarrays. , 2006, BioTechniques.

[28]  K. Kivirikko,et al.  Collagens, modifying enzymes and their mutations in humans, flies and worms. , 2004, Trends in genetics : TIG.

[29]  R. Iozzo,et al.  Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[30]  Valerie M. Weaver,et al.  Three-dimensional context regulation of metastasis , 2008, Clinical & Experimental Metastasis.

[31]  B. Hinz,et al.  Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix , 2007, The Journal of cell biology.

[32]  Ivan Stamenkovic,et al.  Functional structure and composition of the extracellular matrix , 2003, The Journal of pathology.

[33]  David Silverstein,et al.  Growth factor binding to the pericellular matrix and its importance in tissue engineering. , 2007, Advanced drug delivery reviews.

[34]  S. Robins Biochemistry and functional significance of collagen cross-linking. , 2007, Biochemical Society transactions.

[35]  Sara Mantero,et al.  Clinical transplantation of a tissue-engineered airway , 2008, The Lancet.

[36]  Viola Vogel,et al.  Force-Induced Unfolding of Fibronectin in the Extracellular Matrix of Living Cells , 2007, PLoS biology.

[37]  Raghu Kalluri,et al.  Structure and Function of Basement Membranes , 2007, Experimental biology and medicine.

[38]  Matthias P Lutolf,et al.  Biopolymeric delivery matrices for angiogenic growth factors. , 2003, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[39]  J. Campisi,et al.  The senescence-associated secretory phenotype: the dark side of tumor suppression. , 2010, Annual review of pathology.

[40]  Arnold Schwarzenegger The aging skin. , 1986, Dermatologic clinics.

[41]  Cynthia A. Reinhart-King,et al.  Tensional homeostasis and the malignant phenotype. , 2005, Cancer cell.

[42]  R. Kamm,et al.  Primary sequence of ionic self-assembling peptide gels affects endothelial cell adhesion and capillary morphogenesis. , 2008, Journal of biomedical materials research. Part A.

[43]  J. Campisi,et al.  Cellular senescence: when bad things happen to good cells , 2007, Nature Reviews Molecular Cell Biology.

[44]  Kwok Yeung Tsang,et al.  The developmental roles of the extracellular matrix: beyond structure to regulation , 2009, Cell and Tissue Research.

[45]  R. Burghardt,et al.  Promoter methylation is associated with the age-dependent loss of N-cadherin in the rat kidney. , 2008, American journal of physiology. Renal physiology.

[46]  J. Hubbell,et al.  Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering , 2005, Nature Biotechnology.

[47]  N. Bark,et al.  Fibrinopeptides and fibrin gel structure. , 2004, Biophysical chemistry.

[48]  Y. Wang,et al.  Cell locomotion and focal adhesions are regulated by substrate flexibility. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[49]  Y. Nomura Structural Change in Decorin with Skin Aging , 2006, Connective tissue research.

[50]  J. Schwarzbauer,et al.  Fibronectin fibrillogenesis, a cell-mediated matrix assembly process. , 2005, Matrix biology : journal of the International Society for Matrix Biology.

[51]  S. Barsky,et al.  Myoepithelial Cells: Autocrine and Paracrine Suppressors of Breast Cancer Progression , 2005, Journal of Mammary Gland Biology and Neoplasia.

[52]  David G Simpson,et al.  Nanotechnology in the design of soft tissue scaffolds: innovations in structure and function. , 2010, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[53]  S. Madersbacher,et al.  Benign prostatic hyperplasia: age-related tissue-remodeling , 2005, Experimental Gerontology.

[54]  Shuguang Zhang,et al.  Designer self-assembling peptide nanofiber biological materials. , 2010, Chemical Society reviews.

[55]  M. Franklin,et al.  Preliminary experience with new bioactive prosthetic material for repair of hernias in infected fields , 2002, Hernia.

[56]  Laura A. Smith,et al.  Nanostructured polymer scaffolds for tissue engineering and regenerative medicine. , 2009, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[57]  Laura A. Smith,et al.  Nano-fibrous scaffolds for tissue engineering. , 2004, Colloids and surfaces. B, Biointerfaces.

[58]  Matthias Schäfer,et al.  Cancer as an overhealing wound: an old hypothesis revisited , 2008, Nature Reviews Molecular Cell Biology.

[59]  Anthony Callanan,et al.  Fibrin: A Natural Biodegradable Scaffold in Vascular Tissue Engineering , 2008, Cells Tissues Organs.

[60]  Micah Dembo,et al.  Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis. , 2007, The international journal of biochemistry & cell biology.

[61]  J. Karp,et al.  Scaffolds for Tissue , 2003 .

[62]  K. Tryggvason,et al.  Heparan sulfate of perlecan is involved in glomerular filtration. , 2005, Journal of the American Society of Nephrology : JASN.

[63]  Mikala Egeblad,et al.  Dynamic interplay between the collagen scaffold and tumor evolution. , 2010, Current opinion in cell biology.

[64]  R. Khokha,et al.  The role of tissue inhibitors of metalloproteinases in tumorigenesis and metastasis. , 2008, Critical reviews in clinical laboratory sciences.

[65]  K. Midwood,et al.  Regulation of fibroblast migration by tenascin-C. , 2007, Biochemical Society transactions.

[66]  G. Laurie,et al.  Basement membrane complexes with biological activity. , 1986, Biochemistry.

[67]  G. Schultz,et al.  Interactions between extracellular matrix and growth factors in wound healing , 2009, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[68]  R. Iozzo,et al.  Basement membrane proteoglycans: Modulators Par Excellence of cancer growth and angiogenesis , 2009, Molecules and cells.

[69]  Kandice R Johnson,et al.  Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis. , 2007, Methods in cell biology.

[70]  Mina J Bissell,et al.  Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. , 2010, Journal of cell science.

[71]  Mikala Egeblad,et al.  Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling , 2009, Cell.

[72]  J E Scott,et al.  Elasticity in extracellular matrix ‘shape modules’ of tendon, cartilage, etc. A sliding proteoglycan‐filament model , 2003, The Journal of physiology.

[73]  J. Davies,et al.  Molecular Biology of the Cell , 1983, Bristol Medico-Chirurgical Journal.

[74]  J. Couchman,et al.  Syndecans as receptors and organizers of the extracellular matrix , 2009, Cell and Tissue Research.

[75]  David Boettiger,et al.  Mechanically Activated Integrin Switch Controls α5β1 Function , 2009, Science.

[76]  Risto Penttinen,et al.  Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy , 2009, Pharmacological Reviews.

[77]  G. Panayotou,et al.  Modulation of Growth Factor Action by the Extracellular Matrix , 2008, Connective tissue research.

[78]  H. Kagan,et al.  Lysyl oxidase: an oxidative enzyme and effector of cell function , 2006, Cellular and Molecular Life Sciences CMLS.

[79]  M. Simons,et al.  Non-canonical fibroblast growth factor signalling in angiogenesis. , 2008, Cardiovascular research.

[80]  R. Iozzo,et al.  Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction* , 2008, Journal of Biological Chemistry.

[81]  M. Hendrix,et al.  Paradoxical roles for lysyl oxidases in cancer—A prospect , 2007, Journal of cellular biochemistry.

[82]  Z. Werb,et al.  Regulation of matrix biology by matrix metalloproteinases. , 2004, Current opinion in cell biology.

[83]  R. Lovitt,et al.  Atomic force microscopy study of cellulose surface interaction controlled by cellulose binding domains. , 2004, Colloids and surfaces. B, Biointerfaces.

[84]  M. Landthaler,et al.  Skin ageing , 2011, Journal of the European Academy of Dermatology and Venereology : JEADV.

[85]  K. Wilhelm,et al.  A review of ageing and an examination of clinical methods in the assessment of ageing skin. Part 2: Clinical perspectives and clinical methods in the evaluation of ageing skin , 2008, International journal of cosmetic science.

[86]  J. Miner,et al.  Revisiting the glomerular charge barrier in the molecular era , 2008, Current opinion in nephrology and hypertension.

[87]  Paolo P. Provenzano,et al.  Shining new light on 3D cell motility and the metastatic process. , 2009, Trends in cell biology.

[88]  Glenn D Prestwich,et al.  Modular extracellular matrices: solutions for the puzzle. , 2008, Methods.

[89]  Z. Werb,et al.  Matrix Metalloproteinases: Regulators of the Tumor Microenvironment , 2010, Cell.

[90]  A. Rodríguez-Sinovas,et al.  Lysyl oxidase as a potential therapeutic target. , 2008, Drug news & perspectives.

[91]  Mina J. Bissell,et al.  Putting tumours in context , 2001, Nature Reviews Cancer.

[92]  D. Brenner,et al.  Mechanisms of Fibrogenesis , 2008, Experimental biology and medicine.

[93]  David S. Harburger,et al.  Integrin signalling at a glance , 2009, Journal of Cell Science.

[94]  I. Campbell,et al.  Extracellular matrix: from atomic resolution to ultrastructure. , 2007, Current opinion in cell biology.

[95]  Samy Lamouille,et al.  TGF-β-induced epithelial to mesenchymal transition , 2009, Cell Research.

[96]  Matthias P. Lutolf,et al.  Designing materials to direct stem-cell fate , 2009, Nature.

[97]  Ranjna C Dutta,et al.  Cell-interactive 3D-scaffold; advances and applications. , 2009, Biotechnology advances.

[98]  Matthias P Lutolf,et al.  Biomolecular hydrogels formed and degraded via site-specific enzymatic reactions. , 2007, Biomacromolecules.

[99]  Richard O. Hynes,et al.  The Extracellular Matrix: Not Just Pretty Fibrils , 2009, Science.

[100]  RICHARD A.F. CLARK,et al.  Fibrin and Wound Healing , 2001 .

[101]  Giulio Gabbiani,et al.  The stroma reaction myofibroblast: a key player in the control of tumor cell behavior. , 2004, The International journal of developmental biology.

[102]  L. Coussens,et al.  Humoral immunity, inflammation and cancer. , 2007, Current opinion in immunology.

[103]  M. Reed,et al.  Extracellular influences on tumour angiogenesis in the aged host , 2008, British Journal of Cancer.