Photobiomodulation therapy in ophthalmology

mice compared to a control group that didn't receive laser light exposure the first of laser stimulation. lightto Photobiomodulation (PBM) therapy is a form of light therapy that utilizes non-ionizing forms of light sources in the far-red to near-infrared spectrum to produce non-thermal photochemical reactions in different biological structures. The paper reviews the experience of implementing (a) PBM in different fields of medicine (e.g., ophthalmology) and (b) the known mechanisms of PBM-induced effects on cells and tissues.

[1]  S. Z. Scalinci,et al.  Effects of Photo-Biomodulation in Stargardt Disease , 2022, Clinical Ophthalmology (Auckland, N.Z.).

[2]  Jennifer K. Sun,et al.  A Randomized Trial of Photobiomodulation Therapy for Center-Involved Diabetic Macular Edema with Good Visual Acuity (Protocol AE). , 2021, Ophthalmology. Retina.

[3]  Rishi P. Singh,et al.  Photobiomodulation Therapy for Age-Related Macular Degeneration and Diabetic Retinopathy: A Review , 2021, Clinical ophthalmology.

[4]  Rishi P. Singh,et al.  Photobiomodulation therapy in age-related macular degeneration , 2021, Current opinion in ophthalmology.

[5]  B. Newland,et al.  New avenues for therapy in mitochondrial optic neuropathies , 2021, Therapeutic advances in rare disease.

[6]  N. Newman,et al.  Neuro-ophthalmic manifestations of mitochondrial disorders and their management , 2020, Taiwan journal of ophthalmology.

[7]  H. Whelan,et al.  What Lies at the Heart of Photobiomodulation: Light, Cytochrome C Oxidase, and Nitric Oxide—Review of the Evidence , 2020, Photobiomodulation, photomedicine, and laser surgery.

[8]  M. Gillies,et al.  Preclinical and clinical studies of photobiomodulation therapy for macular oedema , 2020, Diabetologia.

[9]  D. Iosifescu,et al.  Transcranial Photobiomodulation For The Management Of Depression: Current Perspectives , 2019, Neuropsychiatric disease and treatment.

[10]  N. Khramenko,et al.  Laser Stimulation of Retina and Optic Nerve in Children with Anisometropic Amblyopia , 2019, International Conference on Advanced Optoelectronics and Lasers.

[11]  J. Eells Mitochondrial Dysfunction in the Aging Retina , 2019, Biology.

[12]  Michael R Hamblin,et al.  Near-infrared photobiomodulation combined with coenzyme Q10 for depression in a mouse model of restraint stress: reduction in oxidative stress, neuroinflammation, and apoptosis , 2019, Brain Research Bulletin.

[13]  T. Kern,et al.  Photobiomodulation Inhibits Long-term Structural and Functional Lesions of Diabetic Retinopathy , 2017, Diabetes.

[14]  R. Devenyi,et al.  Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age‐related macular degeneration , 2016, Acta ophthalmologica.

[15]  Ivayla I Geneva,et al.  Photobiomodulation for the treatment of retinal diseases: a review. , 2016, International journal of ophthalmology.

[16]  T. Kern,et al.  Photobiomodulation Mitigates Diabetes-Induced Retinopathy by Direct and Indirect Mechanisms: Evidence from Intervention Studies in Pigmented Mice , 2015, PloS one.

[17]  H. Hara,et al.  Photobiomodulation with 670 nm light increased phagocytosis in human retinal pigment epithelial cells , 2015, Molecular vision.

[18]  Raymond J Lanzafame,et al.  Low-level light/laser therapy versus photobiomodulation therapy. , 2015, Photomedicine and laser surgery.

[19]  A. Sergienko,et al.  Changes of the optic density of the macular pigment after two courses of low-energy light therapy in patients with dry form of age-related macular degeneration , 2014 .

[20]  T. Kern,et al.  Photobiomodulation in the treatment of patients with non-center-involving diabetic macular oedema , 2014, British Journal of Ophthalmology.

[21]  B. Ivandic,et al.  Low-level laser therapy improves vision in a patient with retinitis pigmentosa. , 2014, Photomedicine and laser surgery.

[22]  A. Harvey,et al.  Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders , 2013, Reviews in the neurosciences.

[23]  G. Jeffery,et al.  Treatment with 670 nm Light Up Regulates Cytochrome C Oxidase Expression and Reduces Inflammation in an Age-Related Macular Degeneration Model , 2013, PloS one.

[24]  U. Mitchell,et al.  Low-Level Laser Treatment with Near-Infrared Light Increases Venous Nitric Oxide Levels Acutely: A Single-Blind, Randomized Clinical Trial of Efficacy , 2013, American journal of physical medicine & rehabilitation.

[25]  J. Heckenlively,et al.  Age-related retinal inflammation is reduced by 670 nm light via increased mitochondrial membrane potential , 2013, Neurobiology of Aging.

[26]  Krisztina Valter,et al.  670 nm Red Light Preconditioning Supports Müller Cell Function: Evidence from the White Light‐induced Damage Model in the Rat Retina † , 2012, Photochemistry and photobiology.

[27]  S. Jarrett,et al.  Consequences of oxidative stress in age-related macular degeneration. , 2012, Molecular aspects of medicine.

[28]  H. Nawashiro,et al.  Focal increase in cerebral blood flow after treatment with near-infrared light to the forehead in a patient in a persistent vegetative state. , 2012, Photomedicine and laser surgery.

[29]  R. Devenyi,et al.  Photobiomodulation as a New Treatment for Dry Age Related Macular Degeneration. Results from the Toronto and Oak Ridge Photobimodulation Study in AMD (TORPA) , 2012 .

[30]  B. Ivandic,et al.  Low-level laser therapy improves visual acuity in adolescent and adult patients with amblyopia. , 2012, Photomedicine and laser surgery.

[31]  Tianhong Dai,et al.  The Nuts and Bolts of Low-level Laser (Light) Therapy , 2011, Annals of Biomedical Engineering.

[32]  F Gonzalez-Lima,et al.  Low-level light therapy of the eye and brain. , 2011, Eye and brain.

[33]  Krisztina Valter,et al.  Photobiomodulation protects the retina from light-induced photoreceptor degeneration. , 2011, Investigative ophthalmology & visual science.

[34]  Anita Saltmarche,et al.  Improved cognitive function after transcranial, light-emitting diode treatments in chronic, traumatic brain injury: two case reports. , 2011, Photomedicine and laser surgery.

[35]  Michael R Hamblin,et al.  Role of Low‐Level Laser Therapy in Neurorehabilitation , 2010, PM & R : the journal of injury, function, and rehabilitation.

[36]  Satoko Kawauchi,et al.  Targeted increase in cerebral blood flow by transcranial near‐infrared laser irradiation , 2010, Lasers in surgery and medicine.

[37]  M. Wong-Riley Energy metabolism of the visual system. , 2010, Eye and brain.

[38]  G. Baxter,et al.  Laser photobiomodulation of wound healing: a review of experimental studies in mouse and rat animal models. , 2010, Photomedicine and laser surgery.

[39]  Mark I. Johnson,et al.  Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials , 2009, The Lancet.

[40]  Michael R Hamblin,et al.  Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety , 2009, Behavioral and Brain Functions.

[41]  U. Oron,et al.  Reduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy , 2009, Molecular Neurodegeneration.

[42]  P. Pratt,et al.  Enhancement of Nitric Oxide Release from Nitrosyl Hemoglobin and Nitrosyl Myoglobin by Red/Near Infrared Radiation: Potential Role in Cardioprotection , 2009, Journal of molecular and cellular cardiology.

[43]  W. Campbell,et al.  Light therapy and supplementary riboflavin in the SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis (FALS) , 2009, Lasers in surgery and medicine.

[44]  F Gonzalez-Lima,et al.  Neuroprotective Effects of Near-Infrared Light in an In Vivo Model of Mitochondrial Optic Neuropathy , 2008, The Journal of Neuroscience.

[45]  Rong Ying,et al.  Pretreatment with near-infrared light via light-emitting diode provides added benefit against rotenone- and MPP+-induced neurotoxicity , 2008, Brain Research.

[46]  T. Karu Mitochondrial Signaling in Mammalian Cells Activated by Red and Near‐IR Radiation , 2008, Photochemistry and photobiology.

[47]  Da Xing,et al.  Low-Power Laser Irradiation Inhibiting Aβ25-35-induced PC12 Cell Apoptosis via PKC Activation , 2008, Cellular Physiology and Biochemistry.

[48]  B. Ivandic,et al.  Low-level laser therapy improves vision in patients with age-related macular degeneration. , 2008, Photomedicine and laser surgery.

[49]  drdesforges A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders , 2008 .

[50]  S. Michalikova,et al.  Emotional responses and memory performance of middle-aged CD1 mice in a 3D maze: Effects of low infrared light , 2008, Neurobiology of Learning and Memory.

[51]  P. Lapchak,et al.  Transcranial near-infrared light therapy improves motor function following embolic strokes in rabbits: An extended therapeutic window study using continuous and pulse frequency delivery modes , 2007, Neuroscience.

[52]  Marc Fisher,et al.  Infrared Laser Therapy for Ischemic Stroke: A New Treatment Strategy: Results of the NeuroThera Effectiveness and Safety Trial–1 (NEST-1) , 2007, Stroke.

[53]  Amir Oron,et al.  low-level laser therapy applied transcranially to mice following traumatic brain injury significantly reduces long-term neurological deficits. , 2007, Journal of neurotrauma.

[54]  M. Wong-Riley,et al.  Photobiomodulation partially rescues visual cortical neurons from cyanide-induced apoptosis , 2006, Neuroscience.

[55]  Jieli Chen,et al.  Low-Level Laser Therapy Applied Transcranially to Rats After Induction of Stroke Significantly Reduces Long-Term Neurological Deficits , 2006, Stroke.

[56]  Amir Oron,et al.  Transcranial application of low‐energy laser irradiation improves neurological deficits in rats following acute stroke , 2006, Lasers in surgery and medicine.

[57]  T. Karu,et al.  Absorption measurements of a cell monolayer relevant to phototherapy: reduction of cytochrome c oxidase under near IR radiation. , 2005, Journal of photochemistry and photobiology. B, Biology.

[58]  H. Abrahamse,et al.  Low Level Laser Therapy (LLLT) as an Effective Therapeutic Modality for Delayed Wound Healing , 2005, Annals of the New York Academy of Sciences.

[59]  T. Karu,et al.  Exact action spectra for cellular responses relevant to phototherapy. , 2005, Photomedicine and laser surgery.

[60]  Stefano Geuna,et al.  Phototherapy for enhancing peripheral nerve repair: A review of the literature , 2005, Muscle & nerve.

[61]  Kenneth A. Arndt,et al.  Low‐Level Laser Therapy for Wound Healing: Mechanism and Efficacy , 2005, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[62]  Britton Chance,et al.  Photobiomodulation Directly Benefits Primary Neurons Functionally Inactivated by Toxins , 2005, Journal of Biological Chemistry.

[63]  M. D. Lucroy,et al.  Effect of wavelength on low‐intensity laser irradiation‐stimulated cell proliferation in vitro , 2005, Lasers in surgery and medicine.

[64]  Enrique Cadenas,et al.  On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[65]  T. Karu,et al.  A Novel Mitochondrial Signaling Pathway Activated by Visible-to-near Infrared Radiation¶ , 2004, Photochemistry and photobiology.

[66]  Luis De Taboada,et al.  Mechanisms of action of light therapy for stroke and acute myocardial infarction. , 2004, Mitochondrion.

[67]  Stefano Geuna,et al.  Phototherapy promotes regeneration and functional recovery of injured peripheral nerve , 2004, Neurological research.

[68]  Noel T. Whelan,et al.  Therapeutic photobiomodulation for methanol-induced retinal toxicity , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[69]  John C. Sutherland,et al.  Biological Effects of Polychromatic Light¶ , 2002, Photochemistry and photobiology.

[70]  M. Wong-Riley,et al.  Light-emitting diode treatment reverses the effect of TTX on cytochrome oxidase in neurons , 2001, Neuroreport.

[71]  F Gonzalez-Lima,et al.  Energy Hypometabolism in Posterior Cingulate Cortex of Alzheimer's Patients: Superficial Laminar Cytochrome Oxidase Associated with Disease Duration , 2001, The Journal of Neuroscience.

[72]  U. Oron,et al.  Long-term effect of low energy laser irradiation on infarction and reperfusion injury in the rat heart. , 2001, Journal of applied physiology.

[73]  R. Shofti,et al.  Low-Energy Laser Irradiation Reduces Formation of Scar Tissue After Myocardial Infarction in Rats and Dogs , 2001, Circulation.

[74]  T. Karu,et al.  Primary and secondary mechanisms of action of visible to near-IR radiation on cells. , 1999, Journal of photochemistry and photobiology. B, Biology.

[75]  S. Atri,et al.  Effect of helium-neon laser on wound healing. , 1999, Indian journal of experimental biology.

[76]  Tiina I. Karu,et al.  Ultrastructural changes in chondriome of human lymphocytes after irradiation with HeNe laser: appearance of giant mitochondria , 1996, European Conference on Biomedical Optics.

[77]  J P Gage,et al.  A preliminary study of the effects of laser radiation on collagen metabolism in cell culture. , 1996, Australian dental journal.

[78]  K. Harding,et al.  Cutaneous wound healing: a current perspective. , 1995, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[79]  A. J. Nemeth Lasers and wound healing. , 1993, Dermatologic clinics.

[80]  G. Wahl,et al.  [Soft laser in postoperative care in dentoalveolar treatment]. , 1991, ZWR.

[81]  T I Karu,et al.  EFFECTS OF VISIBLE RADIATION ON CULTURED CELLS , 1990, Photochemistry and photobiology.

[82]  E Marra,et al.  Increase in RNA and protein synthesis by mitochondria irradiated with helium-neon laser. , 1989, Biochemical and biophysical research communications.

[83]  Michael Belkin,et al.  Temporal parameters of low energy laser irradiation for optimal delay of post-traumatic degeneration of rat optic nerve , 1989, Brain Research.

[84]  I. M. Catalano,et al.  Increase of proton electrochemical potential and ATP synthesis in rat liver mitochondria irradiated in vitro by helium‐neon laser , 1984, FEBS letters.

[85]  R Bisson,et al.  Structure of cytochrome c oxidase. , 1983, Advances in experimental medicine and biology.

[86]  D T Mason,et al.  Feasibility of intravascular laser irradiation for in vivo visualization and therapy of cardiocirculatory diseases. , 1982, American heart journal.

[87]  P. Görög,et al.  Stimulation of wound healing with laser beam in the rat , 1974, Experientia.

[88]  S. Ennis,et al.  Support for the involvement of complement factor I in age-related macular degeneration , 2010, European Journal of Human Genetics.

[89]  E. Reiman,et al.  Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE ε4 allele, the major late-onset Alzheimer's susceptibility gene. , 2010, Journal of Alzheimer's disease : JAD.

[90]  Keyoumars Ashkan,et al.  Neuroprotection of midbrain dopaminergic cells in MPTP‐treated mice after near‐infrared light treatment , 2010, The Journal of comparative neurology.

[91]  Mark T Gladwin,et al.  Shining a light on tissue NO stores: near infrared release of NO from nitrite and nitrosylated hemes. , 2009, Journal of molecular and cellular cardiology.

[92]  E. Heyman,et al.  HairMax LaserComb® Laser Phototherapy Device in the Treatment of Male Androgenetic Alopecia , 2009, Clinical drug investigation.

[93]  Hsin-Su Yu,et al.  Helium-neon laser irradiation stimulates migration and proliferation in melanocytes and induces repigmentation in segmental-type vitiligo. , 2003, The Journal of investigative dermatology.

[94]  Amir Oron,et al.  Attenuation of infarct size in rats and dogs after myocardial infarction by low‐energy laser irradiation , 2001, Lasers in surgery and medicine.

[95]  T. Karu,et al.  Irradiation with He-Ne laser increases ATP level in cells cultivated in vitro. , 1995, Journal of photochemistry and photobiology. B, Biology.

[96]  M. Schwartz,et al.  Effects of low‐energy He‐Ne laser irradiation on posttraumatic degeneration of adult rabbit optic nerve , 1987, Lasers in surgery and medicine.

[97]  Linnik La,et al.  Prospects for using stimulating laser therapy in ophthalmology , 1982 .

[98]  E. Mester,et al.  Laser stimulation of wound healing. , 1976, Acta chirurgica Academiae Scientiarum Hungaricae.

[99]  E Mester,et al.  [The effect of laser beams on the growth of hair in mice]. , 1968, Radiobiologia, radiotherapia.