Facilitating replication under stress: an oncogenic function of MYC?

[1]  M. Pickering,et al.  miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression , 2009, Oncogene.

[2]  K. Flaherty,et al.  HIF- α effects on c-Myc distinguish two subtypes of sporadic VHL -deficient clear cell renal carcinoma , 2009 .

[3]  Yu Wei,et al.  Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer. , 2008, Cancer cell.

[4]  P. Pelicci,et al.  DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization , 2008, Cell cycle.

[5]  T. Giordano,et al.  C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells , 2008, Oncogene.

[6]  R. Bernards,et al.  Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1 , 2008, The EMBO journal.

[7]  R. Eisenman,et al.  Myc's broad reach. , 2008, Genes & development.

[8]  K. Zeller,et al.  Global Regulation of Nucleotide Biosynthetic Genes by c-Myc , 2008, PloS one.

[9]  O. Fernandez-Capetillo,et al.  ATR signaling can drive cells into senescence in the absence of DNA breaks. , 2008, Genes & development.

[10]  P. Calsou,et al.  c-Myc protein is degraded in response to UV irradiation , 2008, Cell cycle.

[11]  H. Stein,et al.  The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo. , 2007, Blood.

[12]  Jonathan Pevsner,et al.  HIF-dependent antitumorigenic effect of antioxidants in vivo. , 2007, Cancer cell.

[13]  John Lough,et al.  Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response , 2007, Nature.

[14]  W. Gu,et al.  Non-transcriptional control of DNA replication by c-Myc , 2007, Nature.

[15]  J. Cleveland,et al.  Atm Deficiency Affects Both Apoptosis and Proliferation to Augment Myc-Induced Lymphomagenesis , 2007, Molecular Cancer Research.

[16]  John D Gordan,et al.  HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. , 2007, Cancer cell.

[17]  Albert J. Fornace,et al.  Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase , 2006, The Journal of experimental medicine.

[18]  Dimitris Kletsas,et al.  Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints , 2006, Nature.

[19]  Howard Y. Chang,et al.  MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species. , 2006, Cancer research.

[20]  A. Kumagai,et al.  TopBP1 Activates the ATR-ATRIP Complex , 2006, Cell.

[21]  John T. Powers,et al.  ATM promotes apoptosis and suppresses tumorigenesis in response to Myc , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[22]  C. Dang,et al.  Could MYC Induction of Mitochondrial Biogenesis be linked to ROS Production and Genomic Instability? , 2005, Cell cycle.

[23]  Kathryn A. O’Donnell,et al.  Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis , 2005, Molecular and Cellular Biology.

[24]  J. Bartek,et al.  Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage , 2005, Molecular and Cellular Biology.

[25]  A. Harris,et al.  HIF-1α Induces Genetic Instability by Transcriptionally Downregulating MutSα Expression , 2005 .

[26]  Xiao-Fan Wang,et al.  ATR functions as a gene dosage‐dependent tumor suppressor on a mismatch repair‐deficient background , 2004, The EMBO journal.

[27]  J. Gautier,et al.  ATR and ATM regulate the timing of DNA replication origin firing , 2004, Nature Cell Biology.

[28]  T. Graeber,et al.  Myc-driven murine prostate cancer shares molecular features with human prostate tumors. , 2003, Cancer cell.

[29]  Michael Q. Zhang,et al.  A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[30]  D. Hockenbery,et al.  Myc's Mastery of Mitochondrial Mischief , 2003, Cell cycle.

[31]  M. Eilers,et al.  Negative regulation of the mammalian UV response by Myc through association with Miz-1. , 2002, Molecular cell.

[32]  C. Albanese,et al.  E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination. , 2002, Molecular cell.

[33]  G. Wahl,et al.  c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. , 2002, Molecular cell.

[34]  A. Menssen,et al.  Characterization of the c-MYC-regulated transcriptome by SAGE: Identification and analysis of c-MYC target genes , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[35]  J. Massagué,et al.  Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. , 2002, Nature.

[36]  A. Zetterberg,et al.  Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[37]  D. Felsher,et al.  Transient excess of MYC activity can elicit genomic instability and tumorigenesis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[38]  S. Mai,et al.  Myc-induced cyclin D2 genomic instability in murine B cell neoplasms. , 1999, Current topics in microbiology and immunology.

[39]  Y Taya,et al.  Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. , 1998, Science.

[40]  R Rothstein,et al.  A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. , 1998, Molecular cell.

[41]  Y Taya,et al.  Enhanced phosphorylation of p53 by ATM in response to DNA damage. , 1998, Science.

[42]  S. Lowe,et al.  Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a , 1997, Cell.

[43]  B. Amati,et al.  Growth arrest by the cyclin‐dependent kinase inhibitor p27Kip1 is abrogated by c‐Myc. , 1996, The EMBO journal.

[44]  M. Pagano,et al.  Identification of a Myc‐dependent step during the formation of active G1 cyclin‐cdk complexes. , 1995, The EMBO journal.

[45]  J. Bishop,et al.  The MYC protein activates transcription of the alpha‐prothymosin gene. , 1991, The EMBO journal.

[46]  Robert A. Weinberg,et al.  Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes , 1983, Nature.