Interspecies Transmission of Chronic Wasting Disease Prions to Squirrel Monkeys (Saimiri sciureus)

ABSTRACT Chronic wasting disease (CWD) is an emerging prion disease of deer and elk. The risk of CWD transmission to humans following exposure to CWD-infected tissues is unknown. To assess the susceptibility of nonhuman primates to CWD, two squirrel monkeys were inoculated with brain tissue from a CWD-infected mule deer. The CWD-inoculated squirrel monkeys developed a progressive neurodegenerative disease and were euthanized at 31 and 34 months postinfection. Brain tissue from the CWD-infected squirrel monkeys contained the abnormal isoform of the prion protein, PrP-res, and displayed spongiform degeneration. This is the first reported transmission of CWD to primates.

[1]  J. Aiken,et al.  Delay in onset of prion disease for the HY strain of transmissible mink encephalopathy as a result of prior peripheral inoculation with the replication-deficient DY strain. , 2004, The Journal of general virology.

[2]  C. Sigurdson,et al.  Other animal prion diseases. , 2003, British medical bulletin.

[3]  A. Kincaid,et al.  Rapid Prion Neuroinvasion following Tongue Infection , 2003, Journal of Virology.

[4]  L. Schonberger,et al.  Creutzfeldt-Jakob disease in unusually young patients who consumed venison. , 2001, Archives of neurology.

[5]  J. Hauw,et al.  Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt– Jakob disease: Implications for human health , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[6]  G. J. Raymond,et al.  Evidence of a molecular barrier limiting susceptibility of humans, cattle and sheep to chronic wasting disease , 2000, The EMBO journal.

[7]  E. Granieri,et al.  Case-control study of risk factors of Creutzfeldt-Jakob disease in Europe during 1993-95 , 1998, The Lancet.

[8]  M. Beekes,et al.  Effect of repeated oral infection of hamsters with scrapie. , 1998, The Journal of general virology.

[9]  M. Miller,et al.  SPONGIFORM ENCEPHALOPATHY IN FREE-RANGING MULE DEER (ODOCOILEUS HEMIONUS), WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) AND ROCKY MOUNTAIN ELK (CERVUS ELAPHUS NELSONI) IN NORTHCENTRAL COLORADO , 1997, Journal of wildlife diseases.

[10]  J. Hauw,et al.  BSE transmission to macaques , 1996, Nature.

[11]  M. Beekes,et al.  Western blot mapping of disease-specific amyloid in various animal species and humans with transmissible spongiform encephalopathies using a high-yield purification method. , 1995, The Journal of general virology.

[12]  P. Brown,et al.  Human spongiform encephalopathy: The national institutes of health series of 300 cases of experimentally transmitted disease , 1994, Annals of neurology.

[13]  S. Prusiner,et al.  Transmission of scrapie in hamsters. , 1985, The Journal of infectious diseases.

[14]  E. Williams,et al.  SPONGIFORM ENCEPHALOPATHY OF ROCKY MOUNTAIN ELK1 , 1982, Journal of wildlife diseases.

[15]  Gajdusĕk Dc,et al.  Experimental subacute spongiform virus encephalopathies in primates and other laboratory animals. , 1973 .

[16]  D. Gajdusek,et al.  Experimental Subacute Spongiform Virus Encephalopathies in Primates and Other Laboratory Animals , 1973, Science.

[17]  D. Gajdusek,et al.  Transmission of Scrapie to the Cynomolgus Monkey (Macaca fascicularis) , 1972, Nature.